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A temperature-regulated circuit for feeding behavior

Author

Listed:
  • Shaowen Qian

    (Army Medical University
    The 960th Hospital of Joint Logistics Support Force of PLA (Former Jinan Military General Hospital))

  • Sumei Yan

    (Army Medical University)

  • Ruiqi Pang

    (Army Medical University
    Guangxi University)

  • Jing Zhang

    (National Clinical Research Center for Cancer)

  • Kai Liu

    (The 960th Hospital of Joint Logistics Support Force of PLA (Former Jinan Military General Hospital))

  • Zhiyue Shi

    (Army Medical University)

  • Zhaoqun Wang

    (Army Medical University)

  • Penghui Chen

    (Army Medical University)

  • Yanjie Zhang

    (Army Medical University)

  • Tiantian Luo

    (Army Medical University)

  • Xianli Hu

    (Army Medical University)

  • Ying Xiong

    (Army Medical University)

  • Yi Zhou

    (Army Medical University)

Abstract

Both rodents and primates have evolved to orchestrate food intake to maintain thermal homeostasis in coping with ambient temperature challenges. However, the mechanisms underlying temperature-coordinated feeding behavior are rarely reported. Here we find that a non-canonical feeding center, the anteroventral and periventricular portions of medial preoptic area (apMPOA) respond to altered dietary states in mice. Two neighboring but distinct neuronal populations in apMPOA mediate feeding behavior by receiving anatomical inputs from external and dorsal subnuclei of lateral parabrachial nucleus. While both populations are glutamatergic, the arcuate nucleus-projecting neurons in apMPOA can sense low temperature and promote food intake. The other type, the paraventricular hypothalamic nucleus (PVH)-projecting neurons in apMPOA are primarily sensitive to high temperature and suppress food intake. Caspase ablation or chemogenetic inhibition of the apMPOA→PVH pathway can eliminate the temperature dependence of feeding. Further projection-specific RNA sequencing and fluorescence in situ hybridization identify that the two neuronal populations are molecularly marked by galanin receptor and apelin receptor. These findings reveal unrecognized cell populations and circuits of apMPOA that orchestrates feeding behavior against thermal challenges.

Suggested Citation

  • Shaowen Qian & Sumei Yan & Ruiqi Pang & Jing Zhang & Kai Liu & Zhiyue Shi & Zhaoqun Wang & Penghui Chen & Yanjie Zhang & Tiantian Luo & Xianli Hu & Ying Xiong & Yi Zhou, 2022. "A temperature-regulated circuit for feeding behavior," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
  • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31917-w
    DOI: 10.1038/s41467-022-31917-w
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    References listed on IDEAS

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    1. Ruina Wang & Lei Xiao & Jianbo Pan & Guangsen Bao & Yunmei Zhu & Di Zhu & Jun Wang & Chengfeng Pei & Qinfeng Ma & Xian Fu & Ziruoyu Wang & Mengdi Zhu & Guoxiang Wang & Ling Gong & Qiuping Tong & Min J, 2023. "Natural product P57 induces hypothermia through targeting pyridoxal kinase," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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