IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v583y2020i7814d10.1038_s41586-020-2163-6.html
   My bibliography  Save this article

A discrete neuronal circuit induces a hibernation-like state in rodents

Author

Listed:
  • Tohru M. Takahashi

    (University of Tsukuba
    University of Tsukuba)

  • Genshiro A. Sunagawa

    (RIKEN Center for Biosystems Dynamics Research)

  • Shingo Soya

    (University of Tsukuba)

  • Manabu Abe

    (Niigata University
    Niigata University)

  • Katsuyasu Sakurai

    (University of Tsukuba)

  • Kiyomi Ishikawa

    (RIKEN Center for Biosystems Dynamics Research)

  • Masashi Yanagisawa

    (University of Tsukuba)

  • Hiroshi Hama

    (RIKEN Center for Brain Science)

  • Emi Hasegawa

    (University of Tsukuba)

  • Atsushi Miyawaki

    (RIKEN Center for Brain Science)

  • Kenji Sakimura

    (Niigata University)

  • Masayo Takahashi

    (RIKEN Center for Biosystems Dynamics Research)

  • Takeshi Sakurai

    (University of Tsukuba
    University of Tsukuba
    University of Tsukuba)

Abstract

Hibernating mammals actively lower their body temperature to reduce energy expenditure when facing food scarcity1. This ability to induce a hypometabolic state has evoked great interest owing to its potential medical benefits2,3. Here we show that a hypothalamic neuronal circuit in rodents induces a long-lasting hypothermic and hypometabolic state similar to hibernation. In this state, although body temperature and levels of oxygen consumption are kept very low, the ability to regulate metabolism still remains functional, as in hibernation4. There was no obvious damage to tissues and organs or abnormalities in behaviour after recovery from this state. Our findings could enable the development of a method to induce a hibernation-like state, which would have potential applications in non-hibernating mammalian species including humans.

Suggested Citation

  • Tohru M. Takahashi & Genshiro A. Sunagawa & Shingo Soya & Manabu Abe & Katsuyasu Sakurai & Kiyomi Ishikawa & Masashi Yanagisawa & Hiroshi Hama & Emi Hasegawa & Atsushi Miyawaki & Kenji Sakimura & Masa, 2020. "A discrete neuronal circuit induces a hibernation-like state in rodents," Nature, Nature, vol. 583(7814), pages 109-114, July.
  • Handle: RePEc:nat:nature:v:583:y:2020:i:7814:d:10.1038_s41586-020-2163-6
    DOI: 10.1038/s41586-020-2163-6
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41586-020-2163-6
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.

    File URL: https://libkey.io/10.1038/s41586-020-2163-6?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Shuai Zhang & Xinpei Zhang & Haolin Zhong & Xuanyi Li & Yujie Wu & Jun Ju & Bo Liu & Zhenyu Zhang & Hai Yan & Yizheng Wang & Kun Song & Sheng-Tao Hou, 2022. "Hypothermia evoked by stimulation of medial preoptic nucleus protects the brain in a mouse model of ischaemia," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Ruina Wang & Lei Xiao & Jianbo Pan & Guangsen Bao & Yunmei Zhu & Di Zhu & Jun Wang & Chengfeng Pei & Qinfeng Ma & Xian Fu & Ziruoyu Wang & Mengdi Zhu & Guoxiang Wang & Ling Gong & Qiuping Tong & Min J, 2023. "Natural product P57 induces hypothermia through targeting pyridoxal kinase," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    3. Shaowen Qian & Sumei Yan & Ruiqi Pang & Jing Zhang & Kai Liu & Zhiyue Shi & Zhaoqun Wang & Penghui Chen & Yanjie Zhang & Tiantian Luo & Xianli Hu & Ying Xiong & Yi Zhou, 2022. "A temperature-regulated circuit for feeding behavior," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    4. Aika Iwama & Ryoji Kise & Hiroaki Akasaka & Fumiya K. Sano & Hidetaka S. Oshima & Asuka Inoue & Wataru Shihoya & Osamu Nureki, 2024. "Structure and dynamics of the pyroglutamylated RF-amide peptide QRFP receptor GPR103," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    5. Masafumi Tsurutani & Teppei Goto & Mitsue Hagihara & Satsuki Irie & Kazunari Miyamichi, 2024. "Selective vulnerability of parvocellular oxytocin neurons in social dysfunction," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:583:y:2020:i:7814:d:10.1038_s41586-020-2163-6. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.