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A discrete neuronal circuit induces a hibernation-like state in rodents

Author

Listed:
  • Tohru M. Takahashi

    (University of Tsukuba
    University of Tsukuba)

  • Genshiro A. Sunagawa

    (RIKEN Center for Biosystems Dynamics Research)

  • Shingo Soya

    (University of Tsukuba)

  • Manabu Abe

    (Niigata University
    Niigata University)

  • Katsuyasu Sakurai

    (University of Tsukuba)

  • Kiyomi Ishikawa

    (RIKEN Center for Biosystems Dynamics Research)

  • Masashi Yanagisawa

    (University of Tsukuba)

  • Hiroshi Hama

    (RIKEN Center for Brain Science)

  • Emi Hasegawa

    (University of Tsukuba)

  • Atsushi Miyawaki

    (RIKEN Center for Brain Science)

  • Kenji Sakimura

    (Niigata University)

  • Masayo Takahashi

    (RIKEN Center for Biosystems Dynamics Research)

  • Takeshi Sakurai

    (University of Tsukuba
    University of Tsukuba
    University of Tsukuba)

Abstract

Hibernating mammals actively lower their body temperature to reduce energy expenditure when facing food scarcity1. This ability to induce a hypometabolic state has evoked great interest owing to its potential medical benefits2,3. Here we show that a hypothalamic neuronal circuit in rodents induces a long-lasting hypothermic and hypometabolic state similar to hibernation. In this state, although body temperature and levels of oxygen consumption are kept very low, the ability to regulate metabolism still remains functional, as in hibernation4. There was no obvious damage to tissues and organs or abnormalities in behaviour after recovery from this state. Our findings could enable the development of a method to induce a hibernation-like state, which would have potential applications in non-hibernating mammalian species including humans.

Suggested Citation

  • Tohru M. Takahashi & Genshiro A. Sunagawa & Shingo Soya & Manabu Abe & Katsuyasu Sakurai & Kiyomi Ishikawa & Masashi Yanagisawa & Hiroshi Hama & Emi Hasegawa & Atsushi Miyawaki & Kenji Sakimura & Masa, 2020. "A discrete neuronal circuit induces a hibernation-like state in rodents," Nature, Nature, vol. 583(7814), pages 109-114, July.
    • Handle: RePEc:nat:nature:v:583:y:2020:i:7814:d:10.1038_s41586-020-2163-6
    DOI: 10.1038/s41586-020-2163-6
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    Cited by:

    1. Ruina Wang & Lei Xiao & Jianbo Pan & Guangsen Bao & Yunmei Zhu & Di Zhu & Jun Wang & Chengfeng Pei & Qinfeng Ma & Xian Fu & Ziruoyu Wang & Mengdi Zhu & Guoxiang Wang & Ling Gong & Qiuping Tong & Min J, 2023. "Natural product P57 induces hypothermia through targeting pyridoxal kinase," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Shaowen Qian & Sumei Yan & Ruiqi Pang & Jing Zhang & Kai Liu & Zhiyue Shi & Zhaoqun Wang & Penghui Chen & Yanjie Zhang & Tiantian Luo & Xianli Hu & Ying Xiong & Yi Zhou, 2022. "A temperature-regulated circuit for feeding behavior," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    3. Shuai Zhang & Xinpei Zhang & Haolin Zhong & Xuanyi Li & Yujie Wu & Jun Ju & Bo Liu & Zhenyu Zhang & Hai Yan & Yizheng Wang & Kun Song & Sheng-Tao Hou, 2022. "Hypothermia evoked by stimulation of medial preoptic nucleus protects the brain in a mouse model of ischaemia," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    4. Aika Iwama & Ryoji Kise & Hiroaki Akasaka & Fumiya K. Sano & Hidetaka S. Oshima & Asuka Inoue & Wataru Shihoya & Osamu Nureki, 2024. "Structure and dynamics of the pyroglutamylated RF-amide peptide QRFP receptor GPR103," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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