IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-022-31417-x.html
   My bibliography  Save this article

Mitochondrial fission induces immunoescape in solid tumors through decreasing MHC-I surface expression

Author

Listed:
  • Xinyuan Lei

    (Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
    State University of New York at Stony Brook
    Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation of Sun Yat-Sen Memorial Hospital)

  • Hsinyu Lin

    (Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
    Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation of Sun Yat-Sen Memorial Hospital)

  • Jieqi Wang

    (Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
    Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation of Sun Yat-Sen Memorial Hospital)

  • Zhanpeng Ou

    (Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
    Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation of Sun Yat-Sen Memorial Hospital)

  • Yi Ruan

    (Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
    Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation of Sun Yat-Sen Memorial Hospital)

  • Ananthan Sadagopan

    (Massachusetts General Hospital, Harvard Medical School
    Massachusetts Institute of Technology)

  • Weixiong Chen

    (Longgang District Central Hospital, Affiliated to Guangzhou University of Traditional Chinese Medicine)

  • Shule Xie

    (Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
    Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation of Sun Yat-Sen Memorial Hospital)

  • Baisheng Chen

    (Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University)

  • Qunxing Li

    (Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
    Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation of Sun Yat-Sen Memorial Hospital)

  • Jue Wang

    (Cellular Molecular Diagnostics Center, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University)

  • Huayue Lin

    (Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation of Sun Yat-Sen Memorial Hospital
    Breast Tumor Center, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University)

  • Xiaofeng Zhu

    (Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation of Sun Yat-Sen Memorial Hospital
    Breast Tumor Center, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University)

  • Xiaoqing Yuan

    (Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation of Sun Yat-Sen Memorial Hospital
    Breast Tumor Center, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University)

  • Tian Tian

    (Key Laboratory of Human Functional Genomics of Jiangsu, Nanjing Medical University)

  • Xiaobin Lv

    (Nanchang Key Laboratory of Cancer Pathogenesis and Translational Research, Center Laboratory, the Third Affiliated Hospital, Nanchang University
    Markey Cancer Center, the University of Kentucky, College of Medicine)

  • Sha Fu

    (Cellular Molecular Diagnostics Center, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University)

  • Xiaorui Zhu

    (Yale University of Public Health)

  • Jian Zhou

    (Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine)

  • Guokai Pan

    (Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
    Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation of Sun Yat-Sen Memorial Hospital)

  • Xin Xia

    (Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
    Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation of Sun Yat-Sen Memorial Hospital)

  • Bakhos A. Tannous

    (Massachusetts General Hospital and Harvard Medical School)

  • Soldano Ferrone

    (Massachusetts General Hospital, Harvard Medical School)

  • Song Fan

    (Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
    Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation of Sun Yat-Sen Memorial Hospital)

  • Jinsong Li

    (Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
    Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation of Sun Yat-Sen Memorial Hospital)

Abstract

Mitochondrial dynamics can regulate Major Histocompatibility Complex (MHC)-I antigen expression by cancer cells and their immunogenicity in mice and in patients with malignancies. A crucial role in the mitochondrial fragmentation connection with immunogenicity is played by the IRE1α-XBP-1s axis. XBP-1s is a transcription factor for aminopeptidase TPP2, which inhibits MHC-I complex cell surface expression likely by degrading tumor antigen peptides. Mitochondrial fission inhibition with Mdivi-1 upregulates MHC-I expression on cancer cells and enhances the efficacy of adoptive T cell therapy in patient-derived tumor models. Therefore mitochondrial fission inhibition might provide an approach to enhance the efficacy of T cell-based immunotherapy.

Suggested Citation

  • Xinyuan Lei & Hsinyu Lin & Jieqi Wang & Zhanpeng Ou & Yi Ruan & Ananthan Sadagopan & Weixiong Chen & Shule Xie & Baisheng Chen & Qunxing Li & Jue Wang & Huayue Lin & Xiaofeng Zhu & Xiaoqing Yuan & Tia, 2022. "Mitochondrial fission induces immunoescape in solid tumors through decreasing MHC-I surface expression," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31417-x
    DOI: 10.1038/s41467-022-31417-x
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-022-31417-x
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-022-31417-x?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Xi Chen & Dimitrios Iliopoulos & Qing Zhang & Qianzi Tang & Matthew B. Greenblatt & Maria Hatziapostolou & Elgene Lim & Wai Leong Tam & Min Ni & Yiwen Chen & Junhua Mai & Haifa Shen & Dorothy Z. Hu & , 2014. "XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway," Nature, Nature, vol. 508(7494), pages 103-107, April.
    2. Sebastian Kreiter & Mathias Vormehr & Niels van de Roemer & Mustafa Diken & Martin Löwer & Jan Diekmann & Sebastian Boegel & Barbara Schrörs & Fulvia Vascotto & John C. Castle & Arbel D. Tadmor & Step, 2015. "Erratum: Mutant MHC class II epitopes drive therapeutic immune responses to cancer," Nature, Nature, vol. 523(7560), pages 370-370, July.
    3. Sebastian Kreiter & Mathias Vormehr & Niels van de Roemer & Mustafa Diken & Martin Löwer & Jan Diekmann & Sebastian Boegel & Barbara Schrörs & Fulvia Vascotto & John C. Castle & Arbel D. Tadmor & Step, 2015. "Mutant MHC class II epitopes drive therapeutic immune responses to cancer," Nature, Nature, vol. 520(7549), pages 692-696, April.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Laura Y. Zhou & Fei Zou & Wei Sun, 2023. "Prioritizing candidate peptides for cancer vaccines through predicting peptide presentation by HLA‐I proteins," Biometrics, The International Biometric Society, vol. 79(3), pages 2664-2676, September.
    2. Laurel B. Darragh & Jacob Gadwa & Tiffany T. Pham & Benjamin Court & Brooke Neupert & Nicholas A. Olimpo & Khoa Nguyen & Diemmy Nguyen & Michael W. Knitz & Maureen Hoen & Sophia Corbo & Molishree Josh, 2022. "Elective nodal irradiation mitigates local and systemic immunity generated by combination radiation and immunotherapy in head and neck tumors," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    3. Ariel Isser & Aliyah B. Silver & Hawley C. Pruitt & Michal Mass & Emma H. Elias & Gohta Aihara & Si-Sim Kang & Niklas Bachmann & Ying-Yu Chen & Elissa K. Leonard & Joan G. Bieler & Worarat Chaisawangw, 2022. "Nanoparticle-based modulation of CD4+ T cell effector and helper functions enhances adoptive immunotherapy," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    4. Kevin B. Weyant & Ayomide Oloyede & Sukumar Pal & Julie Liao & Mariela Rivera-De Jesus & Thapakorn Jaroentomeechai & Tyler D. Moeller & Steven Hoang-Phou & Sean F. Gilmore & Riya Singh & Daniel C. Pan, 2023. "A modular vaccine platform enabled by decoration of bacterial outer membrane vesicles with biotinylated antigens," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    5. Jiang-jiang Li & Tiantian Yu & Peiting Zeng & Jingyu Tian & Panpan Liu & Shuang Qiao & Shijun Wen & Yumin Hu & Qiao Liu & Wenhua Lu & Hui Zhang & Peng Huang, 2024. "Wild-type IDH2 is a therapeutic target for triple-negative breast cancer," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    6. Michael J. P. Crowley & Bhavneet Bhinder & Geoffrey J. Markowitz & Mitchell Martin & Akanksha Verma & Tito A. Sandoval & Chang-Suk Chae & Shira Yomtoubian & Yang Hu & Sahil Chopra & Diamile A. Tavarez, 2023. "Tumor-intrinsic IRE1α signaling controls protective immunity in lung cancer," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    7. Bo Wen & Bing Zhang, 2023. "PepQuery2 democratizes public MS proteomics data for rapid peptide searching," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    8. Aitor Almanza & Katarzyna Mnich & Arnaud Blomme & Claire M. Robinson & Giovanny Rodriguez-Blanco & Sylwia Kierszniowska & Eoghan P. McGrath & Matthieu Gallo & Eleftherios Pilalis & Johannes V. Swinnen, 2022. "Regulated IRE1α-dependent decay (RIDD)-mediated reprograming of lipid metabolism in cancer," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31417-x. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.