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Mutant MHC class II epitopes drive therapeutic immune responses to cancer

Author

Listed:
  • Sebastian Kreiter

    (TRON – Translational Oncology at the University Medical Center of Johannes Gutenberg University)

  • Mathias Vormehr

    (Research Center for Immunotherapy (FZI))

  • Niels van de Roemer

    (Research Center for Immunotherapy (FZI))

  • Mustafa Diken

    (TRON – Translational Oncology at the University Medical Center of Johannes Gutenberg University)

  • Martin Löwer

    (TRON – Translational Oncology at the University Medical Center of Johannes Gutenberg University)

  • Jan Diekmann

    (TRON – Translational Oncology at the University Medical Center of Johannes Gutenberg University
    Biopharmaceutical New Technologies (BioNTech) Corporation)

  • Sebastian Boegel

    (TRON – Translational Oncology at the University Medical Center of Johannes Gutenberg University)

  • Barbara Schrörs

    (TRON – Translational Oncology at the University Medical Center of Johannes Gutenberg University)

  • Fulvia Vascotto

    (TRON – Translational Oncology at the University Medical Center of Johannes Gutenberg University)

  • John C. Castle

    (TRON – Translational Oncology at the University Medical Center of Johannes Gutenberg University)

  • Arbel D. Tadmor

    (TRON – Translational Oncology at the University Medical Center of Johannes Gutenberg University)

  • Stephen P. Schoenberger

    (La Jolla Institute for Allergy and Immunology)

  • Christoph Huber

    (Research Center for Immunotherapy (FZI))

  • Özlem Türeci

    (TRON – Translational Oncology at the University Medical Center of Johannes Gutenberg University)

  • Ugur Sahin

    (TRON – Translational Oncology at the University Medical Center of Johannes Gutenberg University
    Research Center for Immunotherapy (FZI)
    Biopharmaceutical New Technologies (BioNTech) Corporation)

Abstract

The authors show that a large fraction of tumour mutations is immunogenic and predominantly recognized by CD4+ T cells; they use these data to design synthetic messenger-RNA-based vaccines specific against tumour mutations, and show that these can reject tumours in mice.

Suggested Citation

  • Sebastian Kreiter & Mathias Vormehr & Niels van de Roemer & Mustafa Diken & Martin Löwer & Jan Diekmann & Sebastian Boegel & Barbara Schrörs & Fulvia Vascotto & John C. Castle & Arbel D. Tadmor & Step, 2015. "Mutant MHC class II epitopes drive therapeutic immune responses to cancer," Nature, Nature, vol. 520(7549), pages 692-696, April.
    • Handle: RePEc:nat:nature:v:520:y:2015:i:7549:d:10.1038_nature14426
    DOI: 10.1038/nature14426
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    Citations

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    Cited by:

    1. Szymon J. Szymura & Lin Wang & Tiantian Zhang & Soung-chul Cha & Joo Song & Zhenyuan Dong & Aaron Anderson & Elizabeth Oh & Vincent Lee & Zhe Wang & Sapna Parshottam & Sheetal Rao & Jasper B. Olsem & , 2024. "Personalized neoantigen vaccines as early intervention in untreated patients with lymphoplasmacytic lymphoma: a non-randomized phase 1 trial," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    2. Ariel Isser & Aliyah B. Silver & Hawley C. Pruitt & Michal Mass & Emma H. Elias & Gohta Aihara & Si-Sim Kang & Niklas Bachmann & Ying-Yu Chen & Elissa K. Leonard & Joan G. Bieler & Worarat Chaisawangw, 2022. "Nanoparticle-based modulation of CD4+ T cell effector and helper functions enhances adoptive immunotherapy," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    3. Laurel B. Darragh & Jacob Gadwa & Tiffany T. Pham & Benjamin Court & Brooke Neupert & Nicholas A. Olimpo & Khoa Nguyen & Diemmy Nguyen & Michael W. Knitz & Maureen Hoen & Sophia Corbo & Molishree Josh, 2022. "Elective nodal irradiation mitigates local and systemic immunity generated by combination radiation and immunotherapy in head and neck tumors," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    4. Kevin B. Weyant & Ayomide Oloyede & Sukumar Pal & Julie Liao & Mariela Rivera-De Jesus & Thapakorn Jaroentomeechai & Tyler D. Moeller & Steven Hoang-Phou & Sean F. Gilmore & Riya Singh & Daniel C. Pan, 2023. "A modular vaccine platform enabled by decoration of bacterial outer membrane vesicles with biotinylated antigens," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    5. Xinyuan Lei & Hsinyu Lin & Jieqi Wang & Zhanpeng Ou & Yi Ruan & Ananthan Sadagopan & Weixiong Chen & Shule Xie & Baisheng Chen & Qunxing Li & Jue Wang & Huayue Lin & Xiaofeng Zhu & Xiaoqing Yuan & Tia, 2022. "Mitochondrial fission induces immunoescape in solid tumors through decreasing MHC-I surface expression," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    6. Laura Y. Zhou & Fei Zou & Wei Sun, 2023. "Prioritizing candidate peptides for cancer vaccines through predicting peptide presentation by HLA‐I proteins," Biometrics, The International Biometric Society, vol. 79(3), pages 2664-2676, September.

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