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XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway

Author

Listed:
  • Xi Chen

    (Sandra and Edward Meyer Cancer Center of Weill Cornell Medical College, 1300 York Avenue
    Weill Cornell Medical College, 1300 York Avenue, New York, New York 10065, USA)

  • Dimitrios Iliopoulos

    (Center for Systems Biomedicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA
    Dana-Farber Cancer Institute)

  • Qing Zhang

    (Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill)

  • Qianzi Tang

    (School of Life Science and Technology, Tongji University
    Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University, Ya’an, Sichuan 625014, China)

  • Matthew B. Greenblatt

    (Brigham and Women's Hospital)

  • Maria Hatziapostolou

    (Center for Systems Biomedicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA
    Dana-Farber Cancer Institute)

  • Elgene Lim

    (Harvard Medical School)

  • Wai Leong Tam

    (Whitehead Institute for Biomedical Research, 9 Cambridge Center)

  • Min Ni

    (Harvard Medical School)

  • Yiwen Chen

    (Dana-Farber Cancer Institute and Harvard School of Public Health)

  • Junhua Mai

    (Houston Methodist Research Institute)

  • Haifa Shen

    (Houston Methodist Research Institute
    Weill Cornell Medical College, 1300 York Avenue, New York, New York 10065, USA)

  • Dorothy Z. Hu

    (Endocrine Unit, Massachusetts General Hospital)

  • Stanley Adoro

    (Sandra and Edward Meyer Cancer Center of Weill Cornell Medical College, 1300 York Avenue
    Weill Cornell Medical College, 1300 York Avenue, New York, New York 10065, USA)

  • Bella Hu

    (Children’s Hospital Boston)

  • Minkyung Song

    (Sandra and Edward Meyer Cancer Center of Weill Cornell Medical College, 1300 York Avenue
    Weill Cornell Medical College, 1300 York Avenue, New York, New York 10065, USA)

  • Chen Tan

    (Sandra and Edward Meyer Cancer Center of Weill Cornell Medical College, 1300 York Avenue
    Weill Cornell Medical College, 1300 York Avenue, New York, New York 10065, USA)

  • Melissa D. Landis

    (Houston Methodist Cancer Center)

  • Mauro Ferrari

    (Weill Cornell Medical College, 1300 York Avenue, New York, New York 10065, USA
    Houston Methodist Research Institute)

  • Sandra J. Shin

    (Weill Cornell Medical College, 1300 York Avenue, New York, New York 10065, USA)

  • Myles Brown

    (Harvard Medical School)

  • Jenny C. Chang

    (Weill Cornell Medical College, 1300 York Avenue, New York, New York 10065, USA
    Houston Methodist Cancer Center)

  • X. Shirley Liu

    (Dana-Farber Cancer Institute and Harvard School of Public Health)

  • Laurie H. Glimcher

    (Sandra and Edward Meyer Cancer Center of Weill Cornell Medical College, 1300 York Avenue
    Weill Cornell Medical College, 1300 York Avenue, New York, New York 10065, USA)

Abstract

This study finds that triple-negative breast cancers (TNBC) show an increased basal level of endoplasmic reticulum stress and activation of the XBP1 branch of the unfolded protein response; furthermore, XBP1 promotes tumour formation of TNBC cell lines by interacting with and regulating HIF1α.

Suggested Citation

  • Xi Chen & Dimitrios Iliopoulos & Qing Zhang & Qianzi Tang & Matthew B. Greenblatt & Maria Hatziapostolou & Elgene Lim & Wai Leong Tam & Min Ni & Yiwen Chen & Junhua Mai & Haifa Shen & Dorothy Z. Hu & , 2014. "XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway," Nature, Nature, vol. 508(7494), pages 103-107, April.
    • Handle: RePEc:nat:nature:v:508:y:2014:i:7494:d:10.1038_nature13119
    DOI: 10.1038/nature13119
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    Cited by:

    1. Michael J. P. Crowley & Bhavneet Bhinder & Geoffrey J. Markowitz & Mitchell Martin & Akanksha Verma & Tito A. Sandoval & Chang-Suk Chae & Shira Yomtoubian & Yang Hu & Sahil Chopra & Diamile A. Tavarez, 2023. "Tumor-intrinsic IRE1α signaling controls protective immunity in lung cancer," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    2. Xinyuan Lei & Hsinyu Lin & Jieqi Wang & Zhanpeng Ou & Yi Ruan & Ananthan Sadagopan & Weixiong Chen & Shule Xie & Baisheng Chen & Qunxing Li & Jue Wang & Huayue Lin & Xiaofeng Zhu & Xiaoqing Yuan & Tia, 2022. "Mitochondrial fission induces immunoescape in solid tumors through decreasing MHC-I surface expression," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    3. Bo Wen & Bing Zhang, 2023. "PepQuery2 democratizes public MS proteomics data for rapid peptide searching," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    4. Aitor Almanza & Katarzyna Mnich & Arnaud Blomme & Claire M. Robinson & Giovanny Rodriguez-Blanco & Sylwia Kierszniowska & Eoghan P. McGrath & Matthieu Gallo & Eleftherios Pilalis & Johannes V. Swinnen, 2022. "Regulated IRE1α-dependent decay (RIDD)-mediated reprograming of lipid metabolism in cancer," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    5. Jiang-jiang Li & Tiantian Yu & Peiting Zeng & Jingyu Tian & Panpan Liu & Shuang Qiao & Shijun Wen & Yumin Hu & Qiao Liu & Wenhua Lu & Hui Zhang & Peng Huang, 2024. "Wild-type IDH2 is a therapeutic target for triple-negative breast cancer," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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