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Clinical relevance of molecular characteristics in Burkitt lymphoma differs according to age

Author

Listed:
  • Birgit Burkhardt

    (University Hospital Münster)

  • Ulf Michgehl

    (University Hospital Münster)

  • Jonas Rohde

    (University Hospital Münster)

  • Tabea Erdmann

    (University Hospital Münster)

  • Philipp Berning

    (University Hospital Münster)

  • Katrin Reutter

    (University Hospital Münster)

  • Marius Rohde

    (University Hospital Giessen)

  • Arndt Borkhardt

    (Heinrich-Heine-University)

  • Thomas Burmeister

    (corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin)

  • Sandeep Dave

    (Duke University)

  • Alexandar Tzankov

    (University Hospital Basel)

  • Martin Dugas

    (Heidelberg University Hospital)

  • Sarah Sandmann

    (University of Münster)

  • Falko Fend

    (University Hospital Tübingen, Eberhard-Karls-University)

  • Jasmin Finger

    (University Hospital Münster)

  • Stephanie Mueller

    (University Hospital Münster)

  • Nicola Gökbuget

    (Goethe University)

  • Torsten Haferlach

    (MLL Munich Leukemia Laboratory)

  • Wolfgang Kern

    (MLL Munich Leukemia Laboratory)

  • Wolfgang Hartmann

    (University Hospital of Münster)

  • Wolfram Klapper

    (University Hospital Schleswig-Holstein)

  • Ilske Oschlies

    (University Hospital Schleswig-Holstein)

  • Julia Richter

    (University Hospital Schleswig-Holstein)

  • Udo Kontny

    (Department of Pediatric and Adolescent Medicine, RWTH Aachen University Hospital)

  • Mathias Lutz

    (University of Augsburg)

  • Britta Maecker-Kolhoff

    (Department of Pediatric Hematology and Oncology)

  • German Ott

    (Robert-Bosch-Krankenhaus, and Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology)

  • Andreas Rosenwald

    (Universität Würzburg and Comprehensive Cancer Centre Mainfranken (CCCMF))

  • Reiner Siebert

    (Ulm University and Ulm University Medical Center)

  • Arend Stackelberg

    (Charité - Universitätsmedizin Berlin)

  • Brigitte Strahm

    (University of Freiburg)

  • Wilhelm Woessmann

    (University Medical Centre Hamburg-Eppendorf)

  • Martin Zimmermann

    (Department of Pediatric Hematology and Oncology)

  • Myroslav Zapukhlyak

    (University Hospital Münster)

  • Michael Grau

    (University Hospital Münster)

  • Georg Lenz

    (University Hospital Münster)

Abstract

While survival has improved for Burkitt lymphoma patients, potential differences in outcome between pediatric and adult patients remain unclear. In both age groups, survival remains poor at relapse. Therefore, we conducted a comparative study in a large pediatric cohort, including 191 cases and 97 samples from adults. While TP53 and CCND3 mutation frequencies are not age related, samples from pediatric patients showed a higher frequency of mutations in ID3, DDX3X, ARID1A and SMARCA4, while several genes such as BCL2 and YY1AP1 are almost exclusively mutated in adult patients. An unbiased analysis reveals a transition of the mutational profile between 25 and 40 years of age. Survival analysis in the pediatric cohort confirms that TP53 mutations are significantly associated with higher incidence of relapse (25 ± 4% versus 6 ± 2%, p-value 0.0002). This identifies a promising molecular marker for relapse incidence in pediatric BL which will be used in future clinical trials.

Suggested Citation

  • Birgit Burkhardt & Ulf Michgehl & Jonas Rohde & Tabea Erdmann & Philipp Berning & Katrin Reutter & Marius Rohde & Arndt Borkhardt & Thomas Burmeister & Sandeep Dave & Alexandar Tzankov & Martin Dugas , 2022. "Clinical relevance of molecular characteristics in Burkitt lymphoma differs according to age," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31355-8
    DOI: 10.1038/s41467-022-31355-8
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    References listed on IDEAS

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