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Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics

Author

Listed:
  • Roland Schmitz

    (Metabolism Branch Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA)

  • Ryan M. Young

    (Metabolism Branch Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA)

  • Michele Ceribelli

    (Metabolism Branch Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA)

  • Sameer Jhavar

    (Metabolism Branch Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA)

  • Wenming Xiao

    (Bioinformatics and Molecular Analysis Section, Center for Information Technology, National Institutes of Health)

  • Meili Zhang

    (Metabolism Branch Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA)

  • George Wright

    (Biometric Research Branch, DCTD, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA)

  • Arthur L. Shaffer

    (Metabolism Branch Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA)

  • Daniel J. Hodson

    (Metabolism Branch Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA)

  • Eric Buras

    (Metabolism Branch Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA)

  • Xuelu Liu

    (Bioinformatics and Molecular Analysis Section, Center for Information Technology, National Institutes of Health)

  • John Powell

    (Bioinformatics and Molecular Analysis Section, Center for Information Technology, National Institutes of Health)

  • Yandan Yang

    (Metabolism Branch Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA)

  • Weihong Xu

    (Metabolism Branch Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA)

  • Hong Zhao

    (Metabolism Branch Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA)

  • Holger Kohlhammer

    (Metabolism Branch Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA)

  • Andreas Rosenwald

    (University of Würzburg, 97080 Würzburg, Germany)

  • Philip Kluin

    (Groningen University Medical Center, University of Groningen, 9713 GZ Groningen, The Netherlands)

  • Hans Konrad Müller-Hermelink

    (University of Würzburg, 97080 Würzburg, Germany)

  • German Ott

    (Robert-Bosch-Krankenhaus, and Dr. Margarete Fischer-Bosch Institute for Clinical Pharmacology, 70376 Stuttgart, Germany)

  • Randy D. Gascoyne

    (British Columbia Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada)

  • Joseph M. Connors

    (British Columbia Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada)

  • Lisa M. Rimsza

    (University of Arizona)

  • Elias Campo

    (Hospital Clinic, University of Barcelona, 08036 Barcelona, Spain)

  • Elaine S. Jaffe

    (Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA)

  • Jan Delabie

    (Pathology Clinic, Rikshospitalet University Hospital, 0372 Oslo, Norway)

  • Erlend B. Smeland

    (Institute for Cancer Research, Rikshospitalet University Hospital and Center for Cancer Biomedicine, University of Oslo, 0310 Oslo, Norway)

  • Martin D. Ogwang

    (St. Mary's Hospital Lacor, Gulu 256, Uganda)

  • Steven J. Reynolds

    (National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Richard I. Fisher

    (James P. Wilmot Cancer Center, University of Rochester School of Medicine, Rochester 14642, New York, USA)

  • Rita M. Braziel

    (Oregon Health and Science University)

  • Raymond R. Tubbs

    (Cleveland Clinic Pathology and Laboratory Medicine Institute)

  • James R. Cook

    (Cleveland Clinic Pathology and Laboratory Medicine Institute)

  • Dennis D. Weisenburger

    (University of Nebraska Medical Center)

  • Wing C. Chan

    (University of Nebraska Medical Center)

  • Stefania Pittaluga

    (Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA)

  • Wyndham Wilson

    (Metabolism Branch Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA)

  • Thomas A. Waldmann

    (Metabolism Branch Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA)

  • Martin Rowe

    (School of Cancer Sciences, Birmingham Cancer Research UK Centre, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK)

  • Sam M. Mbulaiteye

    (Infections and Immunoepidemiology Branch, National Cancer Institute, NIH)

  • Alan B. Rickinson

    (School of Cancer Sciences, Birmingham Cancer Research UK Centre, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK)

  • Louis M. Staudt

    (Metabolism Branch Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA)

Abstract

RNA sequencing of Burkitt lymphoma tumours allows identification of mutations affecting the transcription factor TCF3, its negative regulator ID3 and the cell cycle regulator CCND3; these pathways reveal new targets for potential therapeutic intervention.

Suggested Citation

  • Roland Schmitz & Ryan M. Young & Michele Ceribelli & Sameer Jhavar & Wenming Xiao & Meili Zhang & George Wright & Arthur L. Shaffer & Daniel J. Hodson & Eric Buras & Xuelu Liu & John Powell & Yandan Y, 2012. "Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics," Nature, Nature, vol. 490(7418), pages 116-120, October.
    • Handle: RePEc:nat:nature:v:490:y:2012:i:7418:d:10.1038_nature11378
    DOI: 10.1038/nature11378
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    Citations

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    Cited by:

    1. Weiyin Zhou & Anja Fischer & Martin D. Ogwang & Wen Luo & Patrick Kerchan & Steven J. Reynolds & Constance N. Tenge & Pamela A. Were & Robert T. Kuremu & Walter N. Wekesa & Nestory Masalu & Esther Kaw, 2023. "Mosaic chromosomal alterations in peripheral blood leukocytes of children in sub-Saharan Africa," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    2. Birgit Burkhardt & Ulf Michgehl & Jonas Rohde & Tabea Erdmann & Philipp Berning & Katrin Reutter & Marius Rohde & Arndt Borkhardt & Thomas Burmeister & Sandeep Dave & Alexandar Tzankov & Martin Dugas , 2022. "Clinical relevance of molecular characteristics in Burkitt lymphoma differs according to age," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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