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FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas

Author

Listed:
  • Shanshan Duan

    (NYU Cancer Institute, New York University School of Medicine, 522 First Avenue, SRB 1107, New York, New York 10016, USA
    Howard Hughes Medical Institute, New York University School of Medicine, 522 First Avenue, SRB 1107, New York, New York 10016, USA)

  • Lukas Cermak

    (NYU Cancer Institute, New York University School of Medicine, 522 First Avenue, SRB 1107, New York, New York 10016, USA
    Howard Hughes Medical Institute, New York University School of Medicine, 522 First Avenue, SRB 1107, New York, New York 10016, USA)

  • Julia K. Pagan

    (NYU Cancer Institute, New York University School of Medicine, 522 First Avenue, SRB 1107, New York, New York 10016, USA
    Howard Hughes Medical Institute, New York University School of Medicine, 522 First Avenue, SRB 1107, New York, New York 10016, USA)

  • Mario Rossi

    (NYU Cancer Institute, New York University School of Medicine, 522 First Avenue, SRB 1107, New York, New York 10016, USA)

  • Cinzia Martinengo

    (CERMS, University of Torino, 10126 Torino, Italy)

  • Paola Francia di Celle

    (San Giovanni Battista Hospital, Via Santena 7, 10126 Torino, Italy)

  • Bjoern Chapuy

    (Medical Oncology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, USA)

  • Margaret Shipp

    (Medical Oncology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, USA)

  • Roberto Chiarle

    (CERMS, University of Torino, 10126 Torino, Italy)

  • Michele Pagano

    (NYU Cancer Institute, New York University School of Medicine, 522 First Avenue, SRB 1107, New York, New York 10016, USA
    Howard Hughes Medical Institute, New York University School of Medicine, 522 First Avenue, SRB 1107, New York, New York 10016, USA)

Abstract

FBXO11 is identified as the F-box protein that normally targets BCL6 for degradation, and FBXO11 deletions or mutations that prevent this function and thus stabilize BCL6 are found in B-cell lymphomas.

Suggested Citation

  • Shanshan Duan & Lukas Cermak & Julia K. Pagan & Mario Rossi & Cinzia Martinengo & Paola Francia di Celle & Bjoern Chapuy & Margaret Shipp & Roberto Chiarle & Michele Pagano, 2012. "FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas," Nature, Nature, vol. 481(7379), pages 90-93, January.
    • Handle: RePEc:nat:nature:v:481:y:2012:i:7379:d:10.1038_nature10688
    DOI: 10.1038/nature10688
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    Cited by:

    1. Xuemei Bai & Chao Sui & Feng Liu & Tian Chen & Lei Zhang & Yi Zheng & Bingyu Liu & Chengjiang Gao, 2022. "The protein arginine methyltransferase PRMT9 attenuates MAVS activation through arginine methylation," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    2. Birgit Burkhardt & Ulf Michgehl & Jonas Rohde & Tabea Erdmann & Philipp Berning & Katrin Reutter & Marius Rohde & Arndt Borkhardt & Thomas Burmeister & Sandeep Dave & Alexandar Tzankov & Martin Dugas , 2022. "Clinical relevance of molecular characteristics in Burkitt lymphoma differs according to age," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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