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Peptide nano-blanket impedes fibroblasts activation and subsequent formation of pre-metastatic niche

Author

Listed:
  • Yi Zhou

    (Zhejiang University)

  • Peng Ke

    (Zhejiang University
    Shengli Clinical Medical College, Fujian Medical University)

  • Xiaoyan Bao

    (Zhejiang University)

  • Honghui Wu

    (Zhejiang University)

  • Yiyi Xia

    (Zhejiang University)

  • Zhentao Zhang

    (Zhejiang University)

  • Haiqing Zhong

    (Zhejiang University)

  • Qi Dai

    (Zhejiang University
    Key Laboratory of Cancer Prevention and Intervention, The Second Affiliated Hospital, College of Medicine, Zhejiang University)

  • Linjie Wu

    (Zhejiang University)

  • Tiantian Wang

    (Zhejiang University)

  • Mengting Lin

    (Zhejiang University)

  • Yaosheng Li

    (Zhejiang University)

  • Xinchi Jiang

    (Zhejiang University)

  • Qiyao Yang

    (Zhejiang University
    Key Laboratory of Cancer Prevention and Intervention, The Second Affiliated Hospital, College of Medicine, Zhejiang University)

  • Yiying Lu

    (Zhejiang University)

  • Xincheng Zhong

    (Zhejiang University)

  • Min Han

    (Zhejiang University
    Cancer Center of Zhejiang University, Zhejiang University
    Hangzhou Institute of Innovative Medicine, Zhejiang University)

  • Jianqing Gao

    (Zhejiang University
    Cancer Center of Zhejiang University, Zhejiang University
    Hangzhou Institute of Innovative Medicine, Zhejiang University)

Abstract

There is evidence to suggest that the primary tumor induces the formation of a pre-metastatic niche in distal organs by stimulating the production of pro-metastatic factors. Given the fundamental role of the pre-metastatic niche in the development of metastases, interruption of its formation would be a promising strategy to take early action against tumor metastasis. Here we report an enzyme-activated assembled peptide FR17 that can serve as a “flame-retarding blanket” in the pre-metastatic niche specifically to extinguish the “fire” of tumor-supportive microenvironment adaption. We show that the in-situ assembled peptide nano-blanket inhibits fibroblasts activation, suppressing the remodeling of the metastasis-supportive host stromal tissue, and reversing vascular destabilization and angiogenesis. Furthermore, we demonstrate that the nano-blanket prevents the recruitment of myeloid cells to the pre-metastatic niche, regulating the immune-suppressive microenvironment. We show that FR17 administration effectively inhibits the formation of the pulmonary pre-metastatic niche and postoperative metastasis, offering a therapeutic strategy against pre-metastatic niche formation.

Suggested Citation

  • Yi Zhou & Peng Ke & Xiaoyan Bao & Honghui Wu & Yiyi Xia & Zhentao Zhang & Haiqing Zhong & Qi Dai & Linjie Wu & Tiantian Wang & Mengting Lin & Yaosheng Li & Xinchi Jiang & Qiyao Yang & Yiying Lu & Xinc, 2022. "Peptide nano-blanket impedes fibroblasts activation and subsequent formation of pre-metastatic niche," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
  • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30634-8
    DOI: 10.1038/s41467-022-30634-8
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    References listed on IDEAS

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