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Metabolic control of progenitor cell propagation during Drosophila tracheal remodeling

Author

Listed:
  • Yue Li

    (Zhejiang University School of Medicine
    Zhejiang University School of Medicine)

  • Pengzhen Dong

    (Zhejiang University School of Medicine
    Zhejiang University School of Medicine)

  • Yang Yang

    (Zhejiang University School of Medicine)

  • Tianyu Guo

    (Zhejiang University School of Medicine
    Zhejiang University School of Medicine)

  • Quanyi Zhao

    (Fuwai Hospital)

  • Dan Miao

    (Zhejiang University School of Medicine)

  • Huanle Li

    (Zhejiang University School of Medicine
    Zhejiang University School of Medicine)

  • Tianfeng Lu

    (Zhejiang University School of Medicine
    Zhejiang University School of Medicine)

  • Fanning Xia

    (Zhejiang University School of Medicine
    Zhejiang University School of Medicine)

  • Jialan Lyu

    (Zhejiang University School of Medicine
    Zhejiang University School of Medicine)

  • Jun Ma

    (Zhejiang University School of Medicine
    Zhejiang University School of Medicine)

  • Thomas B. Kornberg

    (University of California San Francisco)

  • Qiang Zhang

    (Zhejiang University School of Medicine)

  • Hai Huang

    (Zhejiang University School of Medicine
    Zhejiang University School of Medicine)

Abstract

Adult progenitor cells in the trachea of Drosophila larvae are activated and migrate out of niches when metamorphosis induces tracheal remodeling. Here we show that in response to metabolic deficiency in decaying tracheal branches, signaling by the insulin pathway controls the progenitor cells by regulating Yorkie (Yki)-dependent proliferation and migration. Yki, a transcription coactivator that is regulated by Hippo signaling, promotes transcriptional activation of cell cycle regulators and components of the extracellular matrix in tracheal progenitor cells. These findings reveal that regulation of Yki signaling by the insulin pathway governs proliferation and migration of tracheal progenitor cells, thereby identifying the regulatory mechanism by which metabolic depression drives progenitor cell activation and cell division that underlies tracheal remodeling.

Suggested Citation

  • Yue Li & Pengzhen Dong & Yang Yang & Tianyu Guo & Quanyi Zhao & Dan Miao & Huanle Li & Tianfeng Lu & Fanning Xia & Jialan Lyu & Jun Ma & Thomas B. Kornberg & Qiang Zhang & Hai Huang, 2022. "Metabolic control of progenitor cell propagation during Drosophila tracheal remodeling," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30492-4
    DOI: 10.1038/s41467-022-30492-4
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    References listed on IDEAS

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    1. Yong suk Cho & Jian Zhu & Shuangxi Li & Bing Wang & Yuhong Han & Jin Jiang, 2018. "Regulation of Yki/Yap subcellular localization and Hpo signaling by a nuclear kinase PRP4K," Nature Communications, Nature, vol. 9(1), pages 1-12, December.
    2. Andrew E. Vaughan & Alexis N. Brumwell & Ying Xi & Jeffrey E. Gotts & Doug G. Brownfield & Barbara Treutlein & Kevin Tan & Victor Tan & Feng Chun Liu & Mark R. Looney & Michael A. Matthay & Jason R. R, 2015. "Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury," Nature, Nature, vol. 517(7536), pages 621-625, January.
    3. Jérôme Bohère & Alexandra Mancheno-Ferris & Sandy Al Hayek & Jennifer Zanet & Philippe Valenti & Kohsuke Akino & Yuya Yamabe & Sachi Inagaki & Hélène Chanut-Delalande & Serge Plaza & Yuji Kageyama & D, 2018. "Shavenbaby and Yorkie mediate Hippo signaling to protect adult stem cells from apoptosis," Nature Communications, Nature, vol. 9(1), pages 1-12, December.
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    Cited by:

    1. Yue Li & Tianfeng Lu & Pengzhen Dong & Jian Chen & Qiang Zhao & Yuying Wang & Tianheng Xiao & Honggang Wu & Quanyi Zhao & Hai Huang, 2024. "A single-cell atlas of Drosophila trachea reveals glycosylation-mediated Notch signaling in cell fate specification," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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