IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-022-30492-4.html
   My bibliography  Save this article

Metabolic control of progenitor cell propagation during Drosophila tracheal remodeling

Author

Listed:
  • Yue Li

    (Zhejiang University School of Medicine
    Zhejiang University School of Medicine)

  • Pengzhen Dong

    (Zhejiang University School of Medicine
    Zhejiang University School of Medicine)

  • Yang Yang

    (Zhejiang University School of Medicine)

  • Tianyu Guo

    (Zhejiang University School of Medicine
    Zhejiang University School of Medicine)

  • Quanyi Zhao

    (Fuwai Hospital)

  • Dan Miao

    (Zhejiang University School of Medicine)

  • Huanle Li

    (Zhejiang University School of Medicine
    Zhejiang University School of Medicine)

  • Tianfeng Lu

    (Zhejiang University School of Medicine
    Zhejiang University School of Medicine)

  • Fanning Xia

    (Zhejiang University School of Medicine
    Zhejiang University School of Medicine)

  • Jialan Lyu

    (Zhejiang University School of Medicine
    Zhejiang University School of Medicine)

  • Jun Ma

    (Zhejiang University School of Medicine
    Zhejiang University School of Medicine)

  • Thomas B. Kornberg

    (University of California San Francisco)

  • Qiang Zhang

    (Zhejiang University School of Medicine)

  • Hai Huang

    (Zhejiang University School of Medicine
    Zhejiang University School of Medicine)

Abstract

Adult progenitor cells in the trachea of Drosophila larvae are activated and migrate out of niches when metamorphosis induces tracheal remodeling. Here we show that in response to metabolic deficiency in decaying tracheal branches, signaling by the insulin pathway controls the progenitor cells by regulating Yorkie (Yki)-dependent proliferation and migration. Yki, a transcription coactivator that is regulated by Hippo signaling, promotes transcriptional activation of cell cycle regulators and components of the extracellular matrix in tracheal progenitor cells. These findings reveal that regulation of Yki signaling by the insulin pathway governs proliferation and migration of tracheal progenitor cells, thereby identifying the regulatory mechanism by which metabolic depression drives progenitor cell activation and cell division that underlies tracheal remodeling.

Suggested Citation

  • Yue Li & Pengzhen Dong & Yang Yang & Tianyu Guo & Quanyi Zhao & Dan Miao & Huanle Li & Tianfeng Lu & Fanning Xia & Jialan Lyu & Jun Ma & Thomas B. Kornberg & Qiang Zhang & Hai Huang, 2022. "Metabolic control of progenitor cell propagation during Drosophila tracheal remodeling," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30492-4
    DOI: 10.1038/s41467-022-30492-4
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-022-30492-4
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-022-30492-4?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Yong suk Cho & Jian Zhu & Shuangxi Li & Bing Wang & Yuhong Han & Jin Jiang, 2018. "Regulation of Yki/Yap subcellular localization and Hpo signaling by a nuclear kinase PRP4K," Nature Communications, Nature, vol. 9(1), pages 1-12, December.
    2. Jérôme Bohère & Alexandra Mancheno-Ferris & Sandy Al Hayek & Jennifer Zanet & Philippe Valenti & Kohsuke Akino & Yuya Yamabe & Sachi Inagaki & Hélène Chanut-Delalande & Serge Plaza & Yuji Kageyama & D, 2018. "Shavenbaby and Yorkie mediate Hippo signaling to protect adult stem cells from apoptosis," Nature Communications, Nature, vol. 9(1), pages 1-12, December.
    3. Andrew E. Vaughan & Alexis N. Brumwell & Ying Xi & Jeffrey E. Gotts & Doug G. Brownfield & Barbara Treutlein & Kevin Tan & Victor Tan & Feng Chun Liu & Mark R. Looney & Michael A. Matthay & Jason R. R, 2015. "Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury," Nature, Nature, vol. 517(7536), pages 621-625, January.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Yue Li & Tianfeng Lu & Pengzhen Dong & Jian Chen & Qiang Zhao & Yuying Wang & Tianheng Xiao & Honggang Wu & Quanyi Zhao & Hai Huang, 2024. "A single-cell atlas of Drosophila trachea reveals glycosylation-mediated Notch signaling in cell fate specification," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Richard J. Hewitt & Franz Puttur & David C. A. Gaboriau & Frédéric Fercoq & Maryline Fresquet & William J. Traves & Laura L. Yates & Simone A. Walker & Philip L. Molyneaux & Samuel V. Kemp & Andrew G., 2023. "Lung extracellular matrix modulates KRT5+ basal cell activity in pulmonary fibrosis," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    2. Laura Heydemann & Małgorzata Ciurkiewicz & Georg Beythien & Kathrin Becker & Klaus Schughart & Stephanie Stanelle-Bertram & Berfin Schaumburg & Nancy Mounogou-Kouassi & Sebastian Beck & Martin Zickler, 2023. "Hamster model for post-COVID-19 alveolar regeneration offers an opportunity to understand post-acute sequelae of SARS-CoV-2," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    3. Ning Yang & Joseph M. Luna & Peihong Dai & Yi Wang & Charles M. Rice & Liang Deng, 2022. "Lung type II alveolar epithelial cells collaborate with CCR2+ inflammatory monocytes in host defense against poxvirus infection," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    4. Andrew K. Beppu & Juanjuan Zhao & Changfu Yao & Gianni Carraro & Edo Israely & Anna Lucia Coelho & Katherine Drake & Cory M. Hogaboam & William C. Parks & Jay K. Kolls & Barry R. Stripp, 2023. "Epithelial plasticity and innate immune activation promote lung tissue remodeling following respiratory viral infection," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    5. Robert M. Cox & Josef D. Wolf & Nicole A. Lieberman & Carolin M. Lieber & Hae-Ji Kang & Zachary M. Sticher & Jeong-Joong Yoon & Meghan K. Andrews & Mugunthan Govindarajan & Rebecca E. Krueger & Elizab, 2024. "Therapeutic mitigation of measles-like immune amnesia and exacerbated disease after prior respiratory virus infections in ferrets," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    6. Yuanyuan Chen & Reka Toth & Sara Chocarro & Dieter Weichenhan & Joschka Hey & Pavlo Lutsik & Stefan Sawall & Georgios T. Stathopoulos & Christoph Plass & Rocio Sotillo, 2022. "Club cells employ regeneration mechanisms during lung tumorigenesis," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    7. Benedikt Jaeger & Jonas Christian Schupp & Linda Plappert & Oliver Terwolbeck & Nataliia Artysh & Gian Kayser & Peggy Engelhard & Taylor Sterling Adams & Robert Zweigerdt & Henning Kempf & Stefan Lien, 2022. "Airway basal cells show a dedifferentiated KRT17highPhenotype and promote fibrosis in idiopathic pulmonary fibrosis," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    8. Xu Li & Shu Zhuo & Ting Zhuang & Yong Suk Cho & Guojin Wu & Yuchen Liu & Kun Mu & Kai Zhang & Peng Su & Yingzi Yang & Cheng Cheng Zhang & Jian Zhu & Jin Jiang, 2022. "YAP inhibits ERα and ER+ breast cancer growth by disrupting a TEAD-ERα signaling axis," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30492-4. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.