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Shavenbaby and Yorkie mediate Hippo signaling to protect adult stem cells from apoptosis

Author

Listed:
  • Jérôme Bohère

    (Université de Toulouse)

  • Alexandra Mancheno-Ferris

    (Université de Toulouse)

  • Sandy Al Hayek

    (Université de Toulouse
    Lebanese University
    Lebanese University)

  • Jennifer Zanet

    (Université de Toulouse)

  • Philippe Valenti

    (Université de Toulouse)

  • Kohsuke Akino

    (Graduate School of Science)

  • Yuya Yamabe

    (Graduate School of Science)

  • Sachi Inagaki

    (Kobe University)

  • Hélène Chanut-Delalande

    (Université de Toulouse)

  • Serge Plaza

    (Université de Toulouse
    Laboratoire de Recherche en Sciences Végétales (LSRV), CNRS, UPS)

  • Yuji Kageyama

    (Graduate School of Science
    Kobe University)

  • Dani Osman

    (Lebanese University
    Lebanese University)

  • Cédric Polesello

    (Université de Toulouse)

  • François Payre

    (Université de Toulouse)

Abstract

To compensate for accumulating damages and cell death, adult homeostasis (e.g., body fluids and secretion) requires organ regeneration, operated by long-lived stem cells. How stem cells can survive throughout the animal life remains poorly understood. Here we show that the transcription factor Shavenbaby (Svb, OvoL in vertebrates) is expressed in renal/nephric stem cells (RNSCs) of Drosophila and required for their maintenance during adulthood. As recently shown in embryos, Svb function in adult RNSCs further needs a post-translational processing mediated by the Polished rice (Pri) smORF peptides and impairing Svb function leads to RNSC apoptosis. We show that Svb interacts both genetically and physically with Yorkie (YAP/TAZ in vertebrates), a nuclear effector of the Hippo pathway, to activate the expression of the inhibitor of apoptosis DIAP1. These data therefore identify Svb as a nuclear effector in the Hippo pathway, critical for the survival of adult somatic stem cells.

Suggested Citation

  • Jérôme Bohère & Alexandra Mancheno-Ferris & Sandy Al Hayek & Jennifer Zanet & Philippe Valenti & Kohsuke Akino & Yuya Yamabe & Sachi Inagaki & Hélène Chanut-Delalande & Serge Plaza & Yuji Kageyama & D, 2018. "Shavenbaby and Yorkie mediate Hippo signaling to protect adult stem cells from apoptosis," Nature Communications, Nature, vol. 9(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-07569-0
    DOI: 10.1038/s41467-018-07569-0
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    Cited by:

    1. Yue Li & Pengzhen Dong & Yang Yang & Tianyu Guo & Quanyi Zhao & Dan Miao & Huanle Li & Tianfeng Lu & Fanning Xia & Jialan Lyu & Jun Ma & Thomas B. Kornberg & Qiang Zhang & Hai Huang, 2022. "Metabolic control of progenitor cell propagation during Drosophila tracheal remodeling," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

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