Lipid droplet degradation by autophagy connects mitochondria metabolism to Prox1-driven expression of lymphatic genes and lymphangiogenesis
Author
Abstract
Suggested Citation
DOI: 10.1038/s41467-022-30490-6
Download full text from publisher
References listed on IDEAS
- Jessalyn M. Ubellacker & Alpaslan Tasdogan & Vijayashree Ramesh & Bo Shen & Evann C. Mitchell & Misty S. Martin-Sandoval & Zhimin Gu & Michael L. McCormick & Alison B. Durham & Douglas R. Spitz & Zhiy, 2020. "Lymph protects metastasizing melanoma cells from ferroptosis," Nature, Nature, vol. 585(7823), pages 113-118, September.
- Tetsuya Saito & Akiko Kuma & Yuki Sugiura & Yoshinobu Ichimura & Miki Obata & Hiroshi Kitamura & Shujiro Okuda & Hyeon-Cheol Lee & Kazutaka Ikeda & Yumi Kanegae & Izumu Saito & Johan Auwerx & Hozumi M, 2019. "Autophagy regulates lipid metabolism through selective turnover of NCoR1," Nature Communications, Nature, vol. 10(1), pages 1-16, December.
- Sandra Schoors & Ulrike Bruning & Rindert Missiaen & Karla C. S. Queiroz & Gitte Borgers & Ilaria Elia & Annalisa Zecchin & Anna Rita Cantelmo & Stefan Christen & Jermaine Goveia & Ward Heggermont & L, 2015. "Fatty acid carbon is essential for dNTP synthesis in endothelial cells," Nature, Nature, vol. 520(7546), pages 192-197, April.
- Brian W. Wong & Xingwu Wang & Annalisa Zecchin & Bernard Thienpont & Ivo Cornelissen & Joanna Kalucka & Melissa García-Caballero & Rindert Missiaen & Hongling Huang & Ulrike Brüning & Silvia Blacher &, 2017. "The role of fatty acid β-oxidation in lymphangiogenesis," Nature, Nature, vol. 542(7639), pages 49-54, February.
- Akiko Kuma & Masahiko Hatano & Makoto Matsui & Akitsugu Yamamoto & Haruaki Nakaya & Tamotsu Yoshimori & Yoshinori Ohsumi & Takeshi Tokuhisa & Noboru Mizushima, 2004. "The role of autophagy during the early neonatal starvation period," Nature, Nature, vol. 432(7020), pages 1032-1036, December.
- Rajat Singh & Susmita Kaushik & Yongjun Wang & Youqing Xiang & Inna Novak & Masaaki Komatsu & Keiji Tanaka & Ana Maria Cuervo & Mark J. Czaja, 2009. "Autophagy regulates lipid metabolism," Nature, Nature, vol. 458(7242), pages 1131-1135, April.
- Sandra Schoors & Ulrike Bruning & Rindert Missiaen & Karla C. S. Queiroz & Gitte Borgers & Ilaria Elia & Annalisa Zecchin & Anna Rita Cantelmo & Stefan Christen & Jermaine Goveia & Ward Heggermont & L, 2015. "Correction: Corrigendum: Fatty acid carbon is essential for dNTP synthesis in endothelial cells," Nature, Nature, vol. 526(7571), pages 144-144, October.
Most related items
These are the items that most often cite the same works as this one and are cited by the same works as this one.- Nieves Montenegro-Navarro & Claudia García-Báez & Melissa García-Caballero, 2023. "Molecular and metabolic orchestration of the lymphatic vasculature in physiology and pathology," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
- Balkrishna Chaube & Kathryn M. Citrin & Mahnaz Sahraei & Abhishek K. Singh & Diego Saenz Urturi & Wen Ding & Richard W. Pierce & Raaisa Raaisa & Rebecca Cardone & Richard Kibbey & Carlos Fernández-Her, 2023. "Suppression of angiopoietin-like 4 reprograms endothelial cell metabolism and inhibits angiogenesis," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
- Jie Wang & Rui Zhao & Sha Xu & Xiang-Yu Zhou & Ke Cai & Yu-Ling Chen & Ze-Yu Zhou & Xin Sun & Yan Shi & Feng Wang & Yong-Hao Gui & Hui Tao & Jian-Yuan Zhao, 2024. "NOTCH1 mitochondria localization during heart development promotes mitochondrial metabolism and the endothelial-to-mesenchymal transition in mice," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
- Kuei-Pin Chung & Chih-Ning Cheng & Yi-Jung Chen & Chia-Lang Hsu & Yen-Lin Huang & Min-Shu Hsieh & Han-Chun Kuo & Ya-Ting Lin & Yi-Hsiu Juan & Kiichi Nakahira & Yen-Fu Chen & Wei-Lun Liu & Sheng-Yuan R, 2024. "Alveolar epithelial cells mitigate neutrophilic inflammation in lung injury through regulating mitochondrial fatty acid oxidation," Nature Communications, Nature, vol. 15(1), pages 1-23, December.
- Ling Tao & Mahmoud A. Mohammad & Giorgio Milazzo & Myrthala Moreno-Smith & Tajhal D. Patel & Barry Zorman & Andrew Badachhape & Blanca E. Hernandez & Amber B. Wolf & Zihua Zeng & Jennifer H. Foster & , 2022. "MYCN-driven fatty acid uptake is a metabolic vulnerability in neuroblastoma," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
- Vincent Geldhof & Laura P. M. H. Rooij & Liliana Sokol & Jacob Amersfoort & Maxim Schepper & Katerina Rohlenova & Griet Hoste & Adriaan Vanderstichele & Anne-Marie Delsupehe & Edoardo Isnaldi & Naima , 2022. "Single cell atlas identifies lipid-processing and immunomodulatory endothelial cells in healthy and malignant breast," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
- Yi Lei & Qiangyun Liu & Binggui Chen & Fangfang Wu & Yiming Li & Xue Dong & Nina Ma & Ziru Wu & Yanfang Zhu & Lu Wang & Yuxin Fu & Yuming Liu & Yinting Song & Mei Du & Heng Zhang & Jidong Zhu & Timoth, 2024. "Protein O-GlcNAcylation coupled to Hippo signaling drives vascular dysfunction in diabetic retinopathy," Nature Communications, Nature, vol. 15(1), pages 1-23, December.
- Anastasiya Strembitska & Gwenaël Labouèbe & Alexandre Picard & Xavier P. Berney & David Tarussio & Maxime Jan & Bernard Thorens, 2022. "Lipid biosynthesis enzyme Agpat5 in AgRP-neurons is required for insulin-induced hypoglycemia sensing and glucagon secretion," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
- Keiji Kajiwara & Hiroshi Osaki & Steffen Greßies & Keiko Kuwata & Ju Hyun Kim & Tobias Gensch & Yoshikatsu Sato & Frank Glorius & Shigehiro Yamaguchi & Masayasu Taki, 2022. "A negative-solvatochromic fluorescent probe for visualizing intracellular distributions of fatty acid metabolites," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
- He Yan & Zhen Lu & Xiaojuan Du & Zhengtao You & Mingkang Yang & Nianle Li & Xuequan Li & Zailue Ni & Hong Wu & Xiangfeng Wang & Lifeng Zhao & Hao Wang, 2024. "Autophagy modulates Arabidopsis male gametophyte fertility and controls actin organization," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
- Lin-lin Zhao & Ru Chen & Ziyu Bai & Junyi Liu & Yuhao Zhang & Yicheng Zhong & Meng-xiang Sun & Peng Zhao, 2024. "Autophagy-mediated degradation of integumentary tapetum is critical for embryo pattern formation," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
- Wang Peng & Shu Chen & Jingyu Ma & Wenjie Wei & Naixin Lin & Jinchao Xing & Wenjing Guo & Heying Li & Liang Zhang & Kuiming Chan & Andrew Yen & Guangyu Zhu & Jianbo Yue, 2025. "Endosomal trafficking participates in lipid droplet catabolism to maintain lipid homeostasis," Nature Communications, Nature, vol. 16(1), pages 1-16, December.
- Hong Huang & Qinqin Ouyang & Min Zhu & Haijia Yu & Kunrong Mei & Rong Liu, 2021. "mTOR-mediated phosphorylation of VAMP8 and SCFD1 regulates autophagosome maturation," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
- Bin Huang & Hui Wang & Shuo Liu & Meng Hao & Dan Luo & Yi Zhou & Ying Huang & Yong Nian & Lei Zhang & Bo Chu & Chengqian Yin, 2025. "Palmitoylation-dependent regulation of GPX4 suppresses ferroptosis," Nature Communications, Nature, vol. 16(1), pages 1-19, December.
- Stefania Crotta & Matteo Villa & Jack Major & Katja Finsterbusch & Miriam Llorian & Peter Carmeliet & Joerg Buescher & Andreas Wack, 2023. "Repair of airway epithelia requires metabolic rewiring towards fatty acid oxidation," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
- Elodie Mailler & Carlos M. Guardia & Xiaofei Bai & Michal Jarnik & Chad D. Williamson & Yan Li & Nunziata Maio & Andy Golden & Juan S. Bonifacino, 2021. "The autophagy protein ATG9A enables lipid mobilization from lipid droplets," Nature Communications, Nature, vol. 12(1), pages 1-19, December.
- Wenjun Wang & Junyang Tan & Xiaomin Liu & Wenqi Guo & Mengmeng Li & Xinjie Liu & Yanyan Liu & Wenyu Dai & Liubing Hu & Yimin Wang & Qiuxia Lu & Wen Xing Lee & Hong-Wen Tang & Qinghua Zhou, 2023. "Cytoplasmic Endonuclease G promotes nonalcoholic fatty liver disease via mTORC2-AKT-ACLY and endoplasmic reticulum stress," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
- Guanlan Hu & Catriona Ling & Lijun Chi & Mehakpreet K. Thind & Samuel Furse & Albert Koulman & Jonathan R. Swann & Dorothy Lee & Marjolein M. Calon & Celine Bourdon & Christian J. Versloot & Barbara M, 2022. "The role of the tryptophan-NAD + pathway in a mouse model of severe malnutrition induced liver dysfunction," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
- Marika K. Kucińska & Juliette Fedry & Carmela Galli & Diego Morone & Andrea Raimondi & Tatiana Soldà & Friedrich Förster & Maurizio Molinari, 2023. "TMX4-driven LINC complex disassembly and asymmetric autophagy of the nuclear envelope upon acute ER stress," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
- Mingming Wu & Xiao Zhang & Weijie Zhang & Yi Shiou Chiou & Wenchang Qian & Xiangtian Liu & Min Zhang & Hong Yan & Shilan Li & Tao Li & Xinghua Han & Pengxu Qian & Suling Liu & Yueyin Pan & Peter E. Lo, 2022. "Cancer stem cell regulated phenotypic plasticity protects metastasized cancer cells from ferroptosis," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
Corrections
All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30490-6. See general information about how to correct material in RePEc.
If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.
If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .
If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.
For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .
Please note that corrections may take a couple of weeks to filter through the various RePEc services.