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A role for microfluidic systems in precision medicine

Author

Listed:
  • Jose M. Ayuso

    (Department of Dermatology, University of Wisconsin
    University of Wisconsin
    University of Wisconsin)

  • María Virumbrales-Muñoz

    (University of Wisconsin
    University of Wisconsin)

  • Joshua M. Lang

    (University of Wisconsin
    University of Wisconsin)

  • David J. Beebe

    (University of Wisconsin
    University of Wisconsin
    University of Wisconsin)

Abstract

Precision oncology continues to challenge the “one-size-fits-all” dogma. Under the precision oncology banner, cancer patients are screened for molecular tumor alterations that predict treatment response, ideally leading to optimal treatments. Functional assays that directly evaluate treatment efficacy on the patient’s cells offer an alternative and complementary tool to improve the accuracy of precision oncology. Unfortunately, traditional Petri dish-based assays overlook much tumor complexity, limiting their potential as predictive functional biomarkers. Here, we review past applications of microfluidic systems for precision medicine and discuss the present and potential future role of functional microfluidic assays as treatment predictors.

Suggested Citation

  • Jose M. Ayuso & María Virumbrales-Muñoz & Joshua M. Lang & David J. Beebe, 2022. "A role for microfluidic systems in precision medicine," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30384-7
    DOI: 10.1038/s41467-022-30384-7
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    References listed on IDEAS

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    1. Sunitha Nagrath & Lecia V. Sequist & Shyamala Maheswaran & Daphne W. Bell & Daniel Irimia & Lindsey Ulkus & Matthew R. Smith & Eunice L. Kwak & Subba Digumarthy & Alona Muzikansky & Paula Ryan & Ulyss, 2007. "Isolation of rare circulating tumour cells in cancer patients by microchip technology," Nature, Nature, vol. 450(7173), pages 1235-1239, December.
    2. Philippe L. Bedard & Aaron R. Hansen & Mark J. Ratain & Lillian L. Siu, 2013. "Tumour heterogeneity in the clinic," Nature, Nature, vol. 501(7467), pages 355-364, September.
    3. Vinay Prasad, 2016. "Perspective: The precision-oncology illusion," Nature, Nature, vol. 537(7619), pages 63-63, September.
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