Author
Listed:
- Sunitha Nagrath
(Surgical Services and BioMEMS Resource Center, Massachusetts General Hospital, Harvard Medical School, and Shriners Hospital for Children, Boston, Massachusetts 02114, USA)
- Lecia V. Sequist
(Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts 02114, USA)
- Shyamala Maheswaran
(Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts 02114, USA)
- Daphne W. Bell
(Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts 02114, USA
Present addresses: National Human Genome Research Institute/NIH Cancer Genetics Branch, Bethesda, Maryland 20892, USA (D.W.B.); Department of Pathology, University of Michigan Health System, Ann Arbor, Michigan 48109, USA (U.J.B.).)
- Daniel Irimia
(Surgical Services and BioMEMS Resource Center, Massachusetts General Hospital, Harvard Medical School, and Shriners Hospital for Children, Boston, Massachusetts 02114, USA)
- Lindsey Ulkus
(Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts 02114, USA)
- Matthew R. Smith
(Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts 02114, USA)
- Eunice L. Kwak
(Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts 02114, USA)
- Subba Digumarthy
(Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts 02114, USA)
- Alona Muzikansky
(Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts 02114, USA)
- Paula Ryan
(Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts 02114, USA)
- Ulysses J. Balis
(Surgical Services and BioMEMS Resource Center, Massachusetts General Hospital, Harvard Medical School, and Shriners Hospital for Children, Boston, Massachusetts 02114, USA
Present addresses: National Human Genome Research Institute/NIH Cancer Genetics Branch, Bethesda, Maryland 20892, USA (D.W.B.); Department of Pathology, University of Michigan Health System, Ann Arbor, Michigan 48109, USA (U.J.B.).)
- Ronald G. Tompkins
(Surgical Services and BioMEMS Resource Center, Massachusetts General Hospital, Harvard Medical School, and Shriners Hospital for Children, Boston, Massachusetts 02114, USA)
- Daniel A. Haber
(Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts 02114, USA)
- Mehmet Toner
(Surgical Services and BioMEMS Resource Center, Massachusetts General Hospital, Harvard Medical School, and Shriners Hospital for Children, Boston, Massachusetts 02114, USA)
Abstract
Out of circulation Viable tumour-derived epithelial cells — or circulating tumour cells (CTCs) — are found in peripheral blood from cancer patients, and are the probable origin of intractable metastatic disease. The isolation of such cells from cancer patients has been proven to be very difficult, primarily due to their exceedingly low numbers in peripheral blood. Now a microfluidic platform 'CTC-chip' has been developed, capable of selective, efficient separation of CTCs from the blood of cancer patients. This new tool could be used in the detection and diagnosis of cancers, and to monitor an individual patient's response to therapy.
Suggested Citation
Sunitha Nagrath & Lecia V. Sequist & Shyamala Maheswaran & Daphne W. Bell & Daniel Irimia & Lindsey Ulkus & Matthew R. Smith & Eunice L. Kwak & Subba Digumarthy & Alona Muzikansky & Paula Ryan & Ulyss, 2007.
"Isolation of rare circulating tumour cells in cancer patients by microchip technology,"
Nature, Nature, vol. 450(7173), pages 1235-1239, December.
Handle:
RePEc:nat:nature:v:450:y:2007:i:7173:d:10.1038_nature06385
DOI: 10.1038/nature06385
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Cited by:
- Mert Boya & Tevhide Ozkaya-Ahmadov & Brandi E. Swain & Chia-Heng Chu & Norh Asmare & Ozgun Civelekoglu & Ruxiu Liu & Dohwan Lee & Sherry Tobia & Shweta Biliya & L. DeEtte McDonald & Bassel Nazha & Ome, 2022.
"High throughput, label-free isolation of circulating tumor cell clusters in meshed microwells,"
Nature Communications, Nature, vol. 13(1), pages 1-13, December.
- Jianwei Huang & Ke Wang & Jianjun Xu & Jian Huang & Tao Zhang, 2013.
"Prognostic Significance of Circulating Tumor Cells in Non-Small-Cell Lung Cancer Patients: A Meta-Analysis,"
PLOS ONE, Public Library of Science, vol. 8(11), pages 1-8, November.
- Jose M. Ayuso & María Virumbrales-Muñoz & Joshua M. Lang & David J. Beebe, 2022.
"A role for microfluidic systems in precision medicine,"
Nature Communications, Nature, vol. 13(1), pages 1-12, December.
- Yiming Ma & Jun Zhang & Yunqing Tian & Yihao Fu & Shu Tian & Qingsi Li & Jing Yang & Lei Zhang, 2023.
"Zwitterionic microgel preservation platform for circulating tumor cells in whole blood specimen,"
Nature Communications, Nature, vol. 14(1), pages 1-14, December.
- Suner Aslı, 2019.
"Clustering methods for single-cell RNA-sequencing expression data: performance evaluation with varying sample sizes and cell compositions,"
Statistical Applications in Genetics and Molecular Biology, De Gruyter, vol. 18(5), pages 1-14, October.
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