IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-022-28941-1.html
   My bibliography  Save this article

Dissociation of tau pathology and neuronal hypometabolism within the ATN framework of Alzheimer’s disease

Author

Listed:
  • Michael Tran Duong

    (University of Pennsylvania
    University of Pennsylvania)

  • Sandhitsu R. Das

    (University of Pennsylvania
    University of Pennsylvania)

  • Xueying Lyu

    (University of Pennsylvania)

  • Long Xie

    (University of Pennsylvania)

  • Hayley Richardson

    (University of Pennsylvania)

  • Sharon X. Xie

    (University of Pennsylvania
    University of Pennsylvania)

  • Paul A. Yushkevich

    (University of Pennsylvania
    University of Pennsylvania
    University of Pennsylvania)

  • David A. Wolk

    (University of Pennsylvania
    University of Pennsylvania
    University of Pennsylvania)

  • Ilya M. Nasrallah

    (University of Pennsylvania
    University of Pennsylvania
    University of Pennsylvania)

Abstract

Alzheimer’s disease (AD) is defined by amyloid (A) and tau (T) pathologies, with T better correlated to neurodegeneration (N). However, T and N have complex regional relationships in part related to non-AD factors that influence N. With machine learning, we assessed heterogeneity in 18F-flortaucipir vs. 18F-fluorodeoxyglucose positron emission tomography as markers of T and neuronal hypometabolism (NM) in 289 symptomatic patients from the Alzheimer’s Disease Neuroimaging Initiative. We identified six T/NM clusters with differing limbic and cortical patterns. The canonical group was defined as the T/NM pattern with lowest regression residuals. Groups resilient to T had less hypometabolism than expected relative to T and displayed better cognition than the canonical group. Groups susceptible to T had more hypometabolism than expected given T and exhibited worse cognitive decline, with imaging and clinical measures concordant with non-AD copathologies. Together, T/NM mismatch reveals distinct imaging signatures with pathobiological and prognostic implications for AD.

Suggested Citation

  • Michael Tran Duong & Sandhitsu R. Das & Xueying Lyu & Long Xie & Hayley Richardson & Sharon X. Xie & Paul A. Yushkevich & David A. Wolk & Ilya M. Nasrallah, 2022. "Dissociation of tau pathology and neuronal hypometabolism within the ATN framework of Alzheimer’s disease," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-28941-1
    DOI: 10.1038/s41467-022-28941-1
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-022-28941-1
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-022-28941-1?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Alexandra L Young & Razvan V Marinescu & Neil P Oxtoby & Martina Bocchetta & Keir Yong & Nicholas C Firth & David M Cash & David L Thomas & Katrina M Dick & Jorge Cardoso & John Swieten & Barbara Borr, 2018. "Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference," Nature Communications, Nature, vol. 9(1), pages 1-16, December.
    2. Robert Thorndike, 1953. "Who belongs in the family?," Psychometrika, Springer;The Psychometric Society, vol. 18(4), pages 267-276, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Koecklin, Manuel Tong & Longoria, Genaro & Fitiwi, Desta Z. & DeCarolis, Joseph F. & Curtis, John, 2021. "Public acceptance of renewable electricity generation and transmission network developments: Insights from Ireland," Energy Policy, Elsevier, vol. 151(C).
    2. Becken, Susanne & Stantic, Bela & Chen, Jinyan & Connolly, Rod M., 2022. "Twitter conversations reveal issue salience of aviation in the broader context of climate change," Journal of Air Transport Management, Elsevier, vol. 98(C).
    3. Orietta Nicolis & Jean Paul Maidana & Fabian Contreras & Danilo Leal, 2024. "Analyzing the Impact of COVID-19 on Economic Sustainability: A Clustering Approach," Sustainability, MDPI, vol. 16(4), pages 1-30, February.
    4. Rockstuhl, Sebastian & Wenninger, Simon & Wiethe, Christian & Ahlrichs, Jakob, 2022. "The influence of risk perception on energy efficiency investments: Evidence from a German survey," Energy Policy, Elsevier, vol. 167(C).
    5. Tong Koecklin, Manuel & Fitiwi, Desta & de Carolis, Joseph F. & Curtis, John, 2020. "Renewable electricity generation and transmission network developments in light of public opposition: Insights from Ireland," Papers WP653, Economic and Social Research Institute (ESRI).
    6. Archana R. Panhalkar & Dharmpal D. Doye, 2020. "An approach of improving decision tree classifier using condensed informative data," DECISION: Official Journal of the Indian Institute of Management Calcutta, Springer;Indian Institute of Management Calcutta, vol. 47(4), pages 431-445, December.
    7. Michele Cincera, 2005. "Firms' productivity growth and R&D spillovers: An analysis of alternative technological proximity measures," Economics of Innovation and New Technology, Taylor & Francis Journals, vol. 14(8), pages 657-682.
    8. Horstmann, Felix, 2017. "Measuring the shopper's attitude toward the point of sale display: Scale development and validation," Journal of Retailing and Consumer Services, Elsevier, vol. 36(C), pages 112-123.
    9. Junyong Jang & Yongbin Cho & Juntae Park, 2024. "Bus Route Sketching: A Multimetric Analysis from the User’s and Operator’s Perspectives," Sustainability, MDPI, vol. 16(16), pages 1-19, August.
    10. Elizaveta Zinovyeva & Raphael C. G. Reule & Wolfgang Karl Hardle, 2021. "Understanding Smart Contracts: Hype or Hope?," Papers 2103.08447, arXiv.org.
    11. Zhao, Yingrui & Hu, Songhua & Zhang, Ming, 2024. "Evaluating equitable Transit-Oriented development (TOD) via the Node-Place-People model," Transportation Research Part A: Policy and Practice, Elsevier, vol. 185(C).
    12. Dario Cottafava & Giulia Sonetti & Paolo Gambino & Andrea Tartaglino, 2018. "Explorative Multidimensional Analysis for Energy Efficiency: DataViz versus Clustering Algorithms," Energies, MDPI, vol. 11(5), pages 1-18, May.
    13. Chester Harris, 1955. "Characteristics of two measures of profile similarity," Psychometrika, Springer;The Psychometric Society, vol. 20(4), pages 289-297, December.
    14. Brian C Wesolowski & Alex Hofmann, 2016. "There’s More to Groove than Bass in Electronic Dance Music: Why Some People Won’t Dance to Techno," PLOS ONE, Public Library of Science, vol. 11(10), pages 1-23, October.
    15. Quang Bao Le & Boubaker Dhehibi, 2019. "A Typology-Based Approach for Assessing Qualities and Determinants of Adoption of Sustainable Water Use Technologies in Coping with Context Diversity: The Case of Mechanized Raised-Bed Technology in E," Sustainability, MDPI, vol. 11(19), pages 1-21, September.
    16. Marrel, Amandine & Iooss, Bertrand, 2024. "Probabilistic surrogate modeling by Gaussian process: A new estimation algorithm for more robust prediction," Reliability Engineering and System Safety, Elsevier, vol. 247(C).
    17. Arévalo, Franklim & Barucca, Paolo & Téllez-León, Isela-Elizabeth & Rodríguez, William & Gage, Gerardo & Morales, Raúl, 2022. "Identifying clusters of anomalous payments in the salvadorian payment system," Latin American Journal of Central Banking (previously Monetaria), Elsevier, vol. 3(1).
    18. Shahzad, Murtuza & Alhoori, Hamed & Freedman, Reva & Rahman, Shaikh Abdul, 2022. "Quantifying the online long-term interest in research," Journal of Informetrics, Elsevier, vol. 16(2).
    19. Ermal Shpuza, 2023. "The shape and size of urban blocks," Environment and Planning B, , vol. 50(1), pages 24-43, January.
    20. Boztug, Yasemin & Reutterer, Thomas, 2008. "A combined approach for segment-specific market basket analysis," European Journal of Operational Research, Elsevier, vol. 187(1), pages 294-312, May.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-28941-1. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.