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Two opposing hippocampus to prefrontal cortex pathways for the control of approach and avoidance behaviour

Author

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  • Candela Sánchez-Bellot

    (University College London, Gower St)

  • Rawan AlSubaie

    (University College London, Gower St)

  • Karyna Mishchanchuk

    (University College London, Gower St)

  • Ryan W. S. Wee

    (University College London, Gower St)

  • Andrew F. MacAskill

    (University College London, Gower St)

Abstract

The decision to either approach or avoid a potentially threatening environment is thought to rely upon the coordinated activity of heterogeneous neural populations in the hippocampus and prefrontal cortex (PFC). However, how this circuitry is organized to flexibly promote both approach or avoidance at different times has remained elusive. Here, we show that the hippocampal projection to PFC is composed of two parallel circuits located in the superficial or deep pyramidal layers of the CA1/subiculum border. These circuits have unique upstream and downstream connectivity, and are differentially active during approach and avoidance behaviour. The superficial population is preferentially connected to widespread PFC inhibitory interneurons, and its activation promotes exploration; while the deep circuit is connected to PFC pyramidal neurons and fast spiking interneurons, and its activation promotes avoidance. Together this provides a mechanism for regulation of behaviour during approach avoidance conflict: through two specialized, parallel circuits that allow bidirectional hippocampal control of PFC.

Suggested Citation

  • Candela Sánchez-Bellot & Rawan AlSubaie & Karyna Mishchanchuk & Ryan W. S. Wee & Andrew F. MacAskill, 2022. "Two opposing hippocampus to prefrontal cortex pathways for the control of approach and avoidance behaviour," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-27977-7
    DOI: 10.1038/s41467-022-27977-7
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    1. Guilin Pi & Di Gao & Dongqin Wu & Yali Wang & Huiyang Lei & Wenbo Zeng & Yang Gao & Huiling Yu & Rui Xiong & Tao Jiang & Shihong Li & Xin Wang & Jing Guo & Si Zhang & Taoyuan Yin & Ting He & Dan Ke & , 2020. "Posterior basolateral amygdala to ventral hippocampal CA1 drives approach behaviour to exert an anxiolytic effect," Nature Communications, Nature, vol. 11(1), pages 1-15, December.
    2. Tara A. LeGates & Mark D. Kvarta & Jessica R. Tooley & T. Chase Francis & Mary Kay Lobo & Meaghan C. Creed & Scott M. Thompson, 2018. "Reward behaviour is regulated by the strength of hippocampus–nucleus accumbens synapses," Nature, Nature, vol. 564(7735), pages 258-262, December.
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    1. Kaizhen Li & Konstantinos Koukoutselos & Masanori Sakaguchi & Stéphane Ciocchi, 2024. "Distinct ventral hippocampal inhibitory microcircuits regulating anxiety and fear behaviors," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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