IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-021-27595-9.html
   My bibliography  Save this article

Robust and durable serological response following pediatric SARS-CoV-2 infection

Author

Listed:
  • Hanna Renk

    (University Children’s Hospital Tübingen)

  • Alex Dulovic

    (NMI Natural and Medical Sciences Institute at the University of Tübingen)

  • Alina Seidel

    (Ulm University Medical Center)

  • Matthias Becker

    (NMI Natural and Medical Sciences Institute at the University of Tübingen)

  • Dorit Fabricius

    (Ulm University Medical Center, Ulm University)

  • Maria Zernickel

    (Ulm University Medical Center, Ulm University)

  • Daniel Junker

    (NMI Natural and Medical Sciences Institute at the University of Tübingen)

  • Rüdiger Groß

    (Ulm University Medical Center)

  • Janis Müller

    (Ulm University Medical Center)

  • Alexander Hilger

    (University of Freiburg)

  • Sebastian F. N. Bode

    (Ulm University Medical Center, Ulm University)

  • Linus Fritsch

    (University of Freiburg)

  • Pauline Frieh

    (University of Freiburg)

  • Anneke Haddad

    (University of Freiburg)

  • Tessa Görne

    (University of Freiburg)

  • Jonathan Remppis

    (University Children’s Hospital Tübingen)

  • Tina Ganzemueller

    (University Hospital Tübingen)

  • Andrea Dietz

    (Ulm University Medical Center)

  • Daniela Huzly

    (Germany and Faculty of Medicine, University of Freiburg)

  • Hartmut Hengel

    (Germany and Faculty of Medicine, University of Freiburg)

  • Klaus Kaier

    (University of Freiburg)

  • Susanne Weber

    (University of Freiburg)

  • Eva-Maria Jacobsen

    (Ulm University Medical Center, Ulm University)

  • Philipp D. Kaiser

    (NMI Natural and Medical Sciences Institute at the University of Tübingen)

  • Bjoern Traenkle

    (NMI Natural and Medical Sciences Institute at the University of Tübingen)

  • Ulrich Rothbauer

    (NMI Natural and Medical Sciences Institute at the University of Tübingen)

  • Maximilian Stich

    (University Children’s Hospital Heidelberg)

  • Burkhard Tönshoff

    (University Children’s Hospital Heidelberg)

  • Georg F. Hoffmann

    (University Children’s Hospital Heidelberg)

  • Barbara Müller

    (Virology, Heidelberg University Hospital)

  • Carolin Ludwig

    (Ulm University
    Institute for Clinical Transfusion Medicine and Immunogenetics
    German Red Cross Blood Transfusion Service)

  • Bernd Jahrsdörfer

    (Ulm University
    Institute for Clinical Transfusion Medicine and Immunogenetics
    German Red Cross Blood Transfusion Service)

  • Hubert Schrezenmeier

    (Ulm University
    Institute for Clinical Transfusion Medicine and Immunogenetics
    German Red Cross Blood Transfusion Service)

  • Andreas Peter

    (University Hospital Tübingen)

  • Sebastian Hörber

    (University Hospital Tübingen)

  • Thomas Iftner

    (University Hospital Tübingen)

  • Jan Münch

    (Ulm University Medical Center)

  • Thomas Stamminger

    (Ulm University Medical Center)

  • Hans-Jürgen Groß

    (Ulm University)

  • Martin Wolkewitz

    (University of Freiburg)

  • Corinna Engel

    (University Children’s Hospital Tübingen
    University Hospital Tübingen)

  • Weimin Liu

    (University of Pennsylvania)

  • Marta Rizzi

    (University of Freiburg)

  • Beatrice H. Hahn

    (University of Pennsylvania)

  • Philipp Henneke

    (University of Freiburg
    University of Freiburg)

  • Axel R. Franz

    (University Children’s Hospital Tübingen
    University Hospital Tübingen)

  • Klaus-Michael Debatin

    (Ulm University Medical Center, Ulm University)

  • Nicole Schneiderhan-Marra

    (NMI Natural and Medical Sciences Institute at the University of Tübingen)

  • Ales Janda

    (Ulm University Medical Center, Ulm University)

  • Roland Elling

    (University of Freiburg
    University of Freiburg)

Abstract

The quality and persistence of children’s humoral immune response following SARS-CoV-2 infection remains largely unknown but will be crucial to guide pediatric SARS-CoV-2 vaccination programs. Here, we examine 548 children and 717 adults within 328 households with at least one member with a previous laboratory-confirmed SARS-CoV-2 infection. We assess serological response at 3–4 months and 11–12 months after infection using a bead-based multiplex immunoassay for 23 human coronavirus antigens including SARS-CoV-2 and its Variants of Concern (VOC) and endemic human coronaviruses (HCoVs), and additionally by three commercial SARS-CoV-2 antibody assays. Neutralization against wild type SARS-CoV-2 and the Delta VOC are analysed in a pseudotyped virus assay. Children, compared to adults, are five times more likely to be asymptomatic, and have higher specific antibody levels which persist longer (96.2% versus 82.9% still seropositive 11–12 months post infection). Of note, symptomatic and asymptomatic infections induce similar humoral responses in all age groups. SARS-CoV-2 infection occurs independent of HCoV serostatus. Neutralization responses of children and adults are similar, although neutralization is reduced for both against the Delta VOC. Overall, the long-term humoral immune response to SARS-CoV-2 infection in children is of longer duration than in adults even after asymptomatic infection.

Suggested Citation

  • Hanna Renk & Alex Dulovic & Alina Seidel & Matthias Becker & Dorit Fabricius & Maria Zernickel & Daniel Junker & Rüdiger Groß & Janis Müller & Alexander Hilger & Sebastian F. N. Bode & Linus Fritsch &, 2022. "Robust and durable serological response following pediatric SARS-CoV-2 infection," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
  • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-021-27595-9
    DOI: 10.1038/s41467-021-27595-9
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-021-27595-9
    File Function: Abstract
    Download Restriction: no

    File URL: https://libkey.io/10.1038/s41467-021-27595-9?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Adam K. Wheatley & Jennifer A. Juno & Jing J. Wang & Kevin J. Selva & Arnold Reynaldi & Hyon-Xhi Tan & Wen Shi Lee & Kathleen M. Wragg & Hannah G. Kelly & Robyn Esterbauer & Samantha K. Davis & Helen , 2021. "Evolution of immune responses to SARS-CoV-2 in mild-moderate COVID-19," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
    2. Davide F. Robbiani & Christian Gaebler & Frauke Muecksch & Julio C. C. Lorenzi & Zijun Wang & Alice Cho & Marianna Agudelo & Christopher O. Barnes & Anna Gazumyan & Shlomo Finkin & Thomas Hägglöf & Th, 2020. "Convergent antibody responses to SARS-CoV-2 in convalescent individuals," Nature, Nature, vol. 584(7821), pages 437-442, August.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Alessia Raineri & Thomas Radtke & Sonja Rueegg & Sarah R. Haile & Dominik Menges & Tala Ballouz & Agne Ulyte & Jan Fehr & Daniel L. Cornejo & Giuseppe Pantaleo & Céline Pellaton & Craig Fenwick & Milo, 2023. "Persistent humoral immune response in youth throughout the COVID-19 pandemic: prospective school-based cohort study," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    2. Eva-Maria Jacobsen & Dorit Fabricius & Magdalena Class & Fernando Topfstedt & Raquel Lorenzetti & Iga Janowska & Franziska Schmidt & Julian Staniek & Maria Zernickel & Thomas Stamminger & Andrea N. Di, 2022. "High antibody levels and reduced cellular response in children up to one year after SARS-CoV-2 infection," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    3. Roxane Dumont & Viviane Richard & Elsa Lorthe & Andrea Loizeau & Francesco Pennacchio & María-Eugenia Zaballa & Hélène Baysson & Mayssam Nehme & Anne Perrin & Arnaud G. L’Huillier & Laurent Kaiser & R, 2022. "A population-based serological study of post-COVID syndrome prevalence and risk factors in children and adolescents," Nature Communications, Nature, vol. 13(1), pages 1-8, December.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Irene A. Abela & Chloé Pasin & Magdalena Schwarzmüller & Selina Epp & Michèle E. Sickmann & Merle M. Schanz & Peter Rusert & Jacqueline Weber & Stefan Schmutz & Annette Audigé & Liridona Maliqi & Anni, 2021. "Multifactorial seroprofiling dissects the contribution of pre-existing human coronaviruses responses to SARS-CoV-2 immunity," Nature Communications, Nature, vol. 12(1), pages 1-18, December.
    2. Haisheng Yu & Banghui Liu & Yudi Zhang & Xijie Gao & Qian Wang & Haitao Xiang & Xiaofang Peng & Caixia Xie & Yaping Wang & Peiyu Hu & Jingrong Shi & Quan Shi & Pingqian Zheng & Chengqian Feng & Guofan, 2023. "Somatically hypermutated antibodies isolated from SARS-CoV-2 Delta infected patients cross-neutralize heterologous variants," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    3. Kevin J. Kramer & Erin M. Wilfong & Kelsey Voss & Sierra M. Barone & Andrea R. Shiakolas & Nagarajan Raju & Caroline E. Roe & Naveenchandra Suryadevara & Lauren M. Walker & Steven C. Wall & Ariana Pau, 2022. "Single-cell profiling of the antigen-specific response to BNT162b2 SARS-CoV-2 RNA vaccine," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    4. Ching-Lin Hsieh & Sarah R. Leist & Emily Happy Miller & Ling Zhou & John M. Powers & Alexandra L. Tse & Albert Wang & Ande West & Mark R. Zweigart & Jonathan C. Schisler & Rohit K. Jangra & Kartik Cha, 2024. "Prefusion-stabilized SARS-CoV-2 S2-only antigen provides protection against SARS-CoV-2 challenge," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    5. Leire Campos-Mata & Benjamin Trinité & Andrea Modrego & Sonia Tejedor Vaquero & Edwards Pradenas & Anna Pons-Grífols & Natalia Rodrigo Melero & Diego Carlero & Silvia Marfil & César Santiago & Dàlia R, 2024. "A monoclonal antibody targeting a large surface of the receptor binding motif shows pan-neutralizing SARS-CoV-2 activity," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    6. A. Brenda Kapingidza & Daniel J. Marston & Caitlin Harris & Daniel Wrapp & Kaitlyn Winters & Dieter Mielke & Lu Xiaozhi & Qi Yin & Andrew Foulger & Rob Parks & Maggie Barr & Amanda Newman & Alexandra , 2023. "Engineered immunogens to elicit antibodies against conserved coronavirus epitopes," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    7. Qihong Yan & Xijie Gao & Banghui Liu & Ruitian Hou & Ping He & Yong Ma & Yudi Zhang & Yanjun Zhang & Zimu Li & Qiuluan Chen & Jingjing Wang & Xiaohan Huang & Huan Liang & Huiran Zheng & Yichen Yao & X, 2024. "Antibodies utilizing VL6-57 light chains target a convergent cryptic epitope on SARS-CoV-2 spike protein and potentially drive the genesis of Omicron variants," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    8. Alessia Raineri & Thomas Radtke & Sonja Rueegg & Sarah R. Haile & Dominik Menges & Tala Ballouz & Agne Ulyte & Jan Fehr & Daniel L. Cornejo & Giuseppe Pantaleo & Céline Pellaton & Craig Fenwick & Milo, 2023. "Persistent humoral immune response in youth throughout the COVID-19 pandemic: prospective school-based cohort study," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    9. Jia Wei & Philippa C. Matthews & Nicole Stoesser & Thomas Maddox & Luke Lorenzi & Ruth Studley & John I. Bell & John N. Newton & Jeremy Farrar & Ian Diamond & Emma Rourke & Alison Howarth & Brian D. M, 2021. "Anti-spike antibody response to natural SARS-CoV-2 infection in the general population," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    10. Tingting Li & Xiaojian Han & Chenjian Gu & Hangtian Guo & Huajun Zhang & Yingming Wang & Chao Hu & Kai Wang & Fengjiang Liu & Feiyang Luo & Yanan Zhang & Jie Hu & Wang Wang & Shenglong Li & Yanan Hao , 2021. "Potent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
    11. Nathan Post & Danielle Eddy & Catherine Huntley & May C I van Schalkwyk & Madhumita Shrotri & David Leeman & Samuel Rigby & Sarah V Williams & William H Bermingham & Paul Kellam & John Maher & Adrian , 2020. "Antibody response to SARS-CoV-2 infection in humans: A systematic review," PLOS ONE, Public Library of Science, vol. 15(12), pages 1-27, December.
    12. Andrew P. Hederman & Harini Natarajan & Leo Heyndrickx & Kevin K. Ariën & Joshua A. Wiener & Peter F. Wright & Evan M. Bloch & Aaron A. R. Tobian & Andrew D. Redd & Joel N. Blankson & Amihai Rottenstr, 2023. "SARS-CoV-2 vaccination elicits broad and potent antibody effector functions to variants of concern in vulnerable populations," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    13. Chengzi I. Kaku & Tyler N. Starr & Panpan Zhou & Haley L. Dugan & Paul Khalifé & Ge Song & Elizabeth R. Champney & Daniel W. Mielcarz & James C. Geoghegan & Dennis R. Burton & Raiees Andrabi & Jesse D, 2023. "Evolution of antibody immunity following Omicron BA.1 breakthrough infection," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    14. Robert W. Aldridge & Alexei Yavlinsky & Vincent Nguyen & Max T. Eyre & Madhumita Shrotri & Annalan M. D. Navaratnam & Sarah Beale & Isobel Braithwaite & Thomas Byrne & Jana Kovar & Ellen Fragaszy & Wi, 2022. "SARS-CoV-2 antibodies and breakthrough infections in the Virus Watch cohort," Nature Communications, Nature, vol. 13(1), pages 1-8, December.
    15. Romain Rouet & Jake Y. Henry & Matt D. Johansen & Meghna Sobti & Harikrishnan Balachandran & David B. Langley & Gregory J. Walker & Helen Lenthall & Jennifer Jackson & Stephanie Ubiparipovic & Ohan Ma, 2023. "Broadly neutralizing SARS-CoV-2 antibodies through epitope-based selection from convalescent patients," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    16. Dominik Menges & Kyra D. Zens & Tala Ballouz & Nicole Caduff & Daniel Llanas-Cornejo & Hélène E. Aschmann & Anja Domenghino & Céline Pellaton & Matthieu Perreau & Craig Fenwick & Giuseppe Pantaleo & C, 2022. "Heterogenous humoral and cellular immune responses with distinct trajectories post-SARS-CoV-2 infection in a population-based cohort," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    17. Kuan-Ying A. Huang & Xiaorui Chen & Arpita Mohapatra & Hong Thuy Vy Nguyen & Lisa Schimanski & Tiong Kit Tan & Pramila Rijal & Susan K. Vester & Rory A. Hills & Mark Howarth & Jennifer R. Keeffe & Ale, 2023. "Structural basis for a conserved neutralization epitope on the receptor-binding domain of SARS-CoV-2," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    18. Alexandra B. Hogan & Patrick Doohan & Sean L. Wu & Daniela Olivera Mesa & Jaspreet Toor & Oliver J. Watson & Peter Winskill & Giovanni Charles & Gregory Barnsley & Eleanor M. Riley & David S. Khoury &, 2023. "Estimating long-term vaccine effectiveness against SARS-CoV-2 variants: a model-based approach," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    19. Deborah Cromer & Megan Steain & Arnold Reynaldi & Timothy E. Schlub & Shanchita R. Khan & Sarah C. Sasson & Stephen J. Kent & David S. Khoury & Miles P. Davenport, 2023. "Predicting vaccine effectiveness against severe COVID-19 over time and against variants: a meta-analysis," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
    20. Khadija Khan & Gila Lustig & Cornelius Römer & Kajal Reedoy & Zesuliwe Jule & Farina Karim & Yashica Ganga & Mallory Bernstein & Zainab Baig & Laurelle Jackson & Boitshoko Mahlangu & Anele Mnguni & Ay, 2023. "Evolution and neutralization escape of the SARS-CoV-2 BA.2.86 subvariant," Nature Communications, Nature, vol. 14(1), pages 1-9, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-021-27595-9. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.