IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v12y2021i1d10.1038_s41467-021-27272-x.html
   My bibliography  Save this article

Dietary essential amino acids restore liver metabolism in ovariectomized mice via hepatic estrogen receptor α

Author

Listed:
  • Sara Della Torre

    (University of Milan
    University of Milan)

  • Valeria Benedusi

    (University of Milan
    University of Milan)

  • Giovanna Pepe

    (University of Milan
    University of Milan)

  • Clara Meda

    (University of Milan)

  • Nicoletta Rizzi

    (University of Milan)

  • Nina Henriette Uhlenhaut

    (Institute for Diabetes and Cancer (IDC), Helmholz Zentrum Munich, Helmholtz Diabetes Center (HMGU)
    Metabolic Programming, TUM School of Life Sciences Weihenstephan)

  • Adriana Maggi

    (University of Milan
    University of Milan)

Abstract

In female mammals, the cessation of ovarian functions is associated with significant metabolic alterations, weight gain, and increased susceptibility to a number of pathologies associated with ageing. The molecular mechanisms triggering these systemic events are unknown because most tissues are responsive to lowered circulating sex steroids. As it has been demonstrated that isoform alpha of the estrogen receptor (ERα) may be activated by both estrogens and amino acids, we test the metabolic effects of a diet enriched in specific amino acids in ovariectomized (OVX) mice. This diet is able to block the OVX-induced weight gain and fat deposition in the liver. The use of liver-specific ERα KO mice demonstrates that the hepatic ERα, through the control of liver lipid metabolism, has a key role in the systemic response to OVX. The study suggests that the liver ERα might be a valuable target for dietary treatments for the post-menopause.

Suggested Citation

  • Sara Della Torre & Valeria Benedusi & Giovanna Pepe & Clara Meda & Nicoletta Rizzi & Nina Henriette Uhlenhaut & Adriana Maggi, 2021. "Dietary essential amino acids restore liver metabolism in ovariectomized mice via hepatic estrogen receptor α," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
  • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-27272-x
    DOI: 10.1038/s41467-021-27272-x
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-021-27272-x
    File Function: Abstract
    Download Restriction: no

    File URL: https://libkey.io/10.1038/s41467-021-27272-x?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Kirsi Auro & Anni Joensuu & Krista Fischer & Johannes Kettunen & Perttu Salo & Hannele Mattsson & Marjo Niironen & Jaakko Kaprio & Johan G. Eriksson & Terho Lehtimäki & Olli Raitakari & Antti Jula & A, 2014. "A metabolic view on menopause and ageing," Nature Communications, Nature, vol. 5(1), pages 1-11, December.
    2. Bohdan B Khomtchouk & James R Hennessy & Claes Wahlestedt, 2017. "shinyheatmap: Ultra fast low memory heatmap web interface for big data genomics," PLOS ONE, Public Library of Science, vol. 12(5), pages 1-9, May.
    3. Fran Supek & Matko Bošnjak & Nives Škunca & Tomislav Šmuc, 2011. "REVIGO Summarizes and Visualizes Long Lists of Gene Ontology Terms," PLOS ONE, Public Library of Science, vol. 6(7), pages 1-9, July.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Alexander Platzer & Thomas Nussbaumer & Thomas Karonitsch & Josef S Smolen & Daniel Aletaha, 2019. "Analysis of gene expression in rheumatoid arthritis and related conditions offers insights into sex-bias, gene biotypes and co-expression patterns," PLOS ONE, Public Library of Science, vol. 14(7), pages 1-23, July.
    2. Rachel A. Steward & Maaike A. de Jong & Vicencio Oostra & Christopher W. Wheat, 2022. "Alternative splicing in seasonal plasticity and the potential for adaptation to environmental change," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    3. Mathew Pette & Andrew Dimond & António M. Galvão & Steven J. Millership & Wilson To & Chiara Prodani & Gráinne McNamara & Ludovica Bruno & Alessandro Sardini & Zoe Webster & James McGinty & Paul M. W., 2022. "Epigenetic changes induced by in utero dietary challenge result in phenotypic variability in successive generations of mice," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    4. Nicola G Criscuolo & Claudia Angelini, 2020. "StructuRly: A novel shiny app to produce comprehensive, detailed and interactive plots for population genetic analysis," PLOS ONE, Public Library of Science, vol. 15(2), pages 1-12, February.
    5. David R. Ghasemi & Konstantin Okonechnikov & Anne Rademacher & Stephan Tirier & Kendra K. Maass & Hanna Schumacher & Piyush Joshi & Maxwell P. Gold & Julia Sundheimer & Britta Statz & Ahmet S. Rifaiog, 2024. "Compartments in medulloblastoma with extensive nodularity are connected through differentiation along the granular precursor lineage," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    6. Logan Brase & Shih-Feng You & Ricardo D’Oliveira Albanus & Jorge L. Del-Aguila & Yaoyi Dai & Brenna C. Novotny & Carolina Soriano-Tarraga & Taitea Dykstra & Maria Victoria Fernandez & John P. Budde & , 2023. "Single-nucleus RNA-sequencing of autosomal dominant Alzheimer disease and risk variant carriers," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    7. Fabio Alfieri & Giulio Caravagna & Martin H. Schaefer, 2023. "Cancer genomes tolerate deleterious coding mutations through somatic copy number amplifications of wild-type regions," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    8. Jennifer T. Wolstenholme & Justin M. Saunders & Maren Smith & Jason D. Kang & Phillip B. Hylemon & Javier González-Maeso & Andrew Fagan & Derrick Zhao & Masoumeh Sikaroodi & Jeremy Herzog & Amirhossei, 2022. "Reduced alcohol preference and intake after fecal transplant in patients with alcohol use disorder is transmissible to germ-free mice," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    9. G. S. I. Hattich & S. Jokinen & S. Sildever & M. Gareis & J. Heikkinen & N. Junghardt & M. Segovia & M. Machado & C. Sjöqvist, 2024. "Temperature optima of a natural diatom population increases as global warming proceeds," Nature Climate Change, Nature, vol. 14(5), pages 518-525, May.
    10. José Cerca & Bent Petersen & José Miguel Lazaro-Guevara & Angel Rivera-Colón & Siri Birkeland & Joel Vizueta & Siyu Li & Qionghou Li & João Loureiro & Chatchai Kosawang & Patricia Jaramillo Díaz & Gon, 2022. "The genomic basis of the plant island syndrome in Darwin’s giant daisies," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    11. Andrea Ode & Georg N Duda & Sven Geissler & Stephan Pauly & Jan-Erik Ode & Carsten Perka & Patrick Strube, 2014. "Interaction of Age and Mechanical Stability on Bone Defect Healing: An Early Transcriptional Analysis of Fracture Hematoma in Rat," PLOS ONE, Public Library of Science, vol. 9(9), pages 1-11, September.
    12. Angeles Arzalluz-Luque & Pedro Salguero & Sonia Tarazona & Ana Conesa, 2022. "acorde unravels functionally interpretable networks of isoform co-usage from single cell data," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    13. Miguel Rodriguez de los Santos & Brian H. Kopell & Ariela Buxbaum Grice & Gauri Ganesh & Andy Yang & Pardis Amini & Lora E. Liharska & Eric Vornholt & John F. Fullard & Pengfei Dong & Eric Park & Sara, 2024. "Divergent landscapes of A-to-I editing in postmortem and living human brain," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    14. Pau Balart-García & Leandro Aristide & Tessa M. Bradford & Perry G. Beasley-Hall & Slavko Polak & Steven J. B. Cooper & Rosa Fernández, 2023. "Parallel and convergent genomic changes underlie independent subterranean colonization across beetles," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    15. Laura D Hughes & Scott A Lewis & Michael E Hughes, 2017. "ExpressionDB: An open source platform for distributing genome-scale datasets," PLOS ONE, Public Library of Science, vol. 12(11), pages 1-13, November.
    16. Mihaela Pavličev & Caitlin E. McDonough-Goldstein & Andreja Moset Zupan & Lisa Muglia & Yueh-Chiang Hu & Fansheng Kong & Nagendra Monangi & Gülay Dagdas & Nina Zupančič & Jamie Maziarz & Debora Sinner, 2024. "A common allele increases endometrial Wnt4 expression, with antagonistic implications for pregnancy, reproductive cancers, and endometriosis," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    17. Maria C. Virgilio & Barkha Ramnani & Thomas Chen & W. Miguel Disbennett & Jay Lubow & Joshua D. Welch & Kathleen L. Collins, 2024. "HIV-1 Vpr combats the PU.1-driven antiviral response in primary human macrophages," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    18. Yuki Furuta & Haruka Yamamoto & Takeshi Hirakawa & Akira Uemura & Margaret Anne Pelayo & Hideaki Iimura & Naoya Katagiri & Noriko Takeda-Kamiya & Kie Kumaishi & Makoto Shirakawa & Sumie Ishiguro & Yas, 2024. "Petal abscission is promoted by jasmonic acid-induced autophagy at Arabidopsis petal bases," Nature Communications, Nature, vol. 15(1), pages 1-24, December.
    19. Zimai Li & Bhoomika Bhat & Erik T. Frank & Thalita Oliveira-Honorato & Fumika Azuma & Valérie Bachmann & Darren J. Parker & Thomas Schmitt & Evan P. Economo & Yuko Ulrich, 2023. "Behavioural individuality determines infection risk in clonal ant colonies," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    20. Kristina M. Garske & Asha Kar & Caroline Comenho & Brunilda Balliu & David Z. Pan & Yash V. Bhagat & Gregory Rosenberg & Amogha Koka & Sankha Subhra Das & Zong Miao & Janet S. Sinsheimer & Jaakko Kapr, 2023. "Increased body mass index is linked to systemic inflammation through altered chromatin co-accessibility in human preadipocytes," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-27272-x. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.