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Dietary essential amino acids restore liver metabolism in ovariectomized mice via hepatic estrogen receptor α

Author

Listed:
  • Sara Della Torre

    (University of Milan
    University of Milan)

  • Valeria Benedusi

    (University of Milan
    University of Milan)

  • Giovanna Pepe

    (University of Milan
    University of Milan)

  • Clara Meda

    (University of Milan)

  • Nicoletta Rizzi

    (University of Milan)

  • Nina Henriette Uhlenhaut

    (Institute for Diabetes and Cancer (IDC), Helmholz Zentrum Munich, Helmholtz Diabetes Center (HMGU)
    Metabolic Programming, TUM School of Life Sciences Weihenstephan)

  • Adriana Maggi

    (University of Milan
    University of Milan)

Abstract

In female mammals, the cessation of ovarian functions is associated with significant metabolic alterations, weight gain, and increased susceptibility to a number of pathologies associated with ageing. The molecular mechanisms triggering these systemic events are unknown because most tissues are responsive to lowered circulating sex steroids. As it has been demonstrated that isoform alpha of the estrogen receptor (ERα) may be activated by both estrogens and amino acids, we test the metabolic effects of a diet enriched in specific amino acids in ovariectomized (OVX) mice. This diet is able to block the OVX-induced weight gain and fat deposition in the liver. The use of liver-specific ERα KO mice demonstrates that the hepatic ERα, through the control of liver lipid metabolism, has a key role in the systemic response to OVX. The study suggests that the liver ERα might be a valuable target for dietary treatments for the post-menopause.

Suggested Citation

  • Sara Della Torre & Valeria Benedusi & Giovanna Pepe & Clara Meda & Nicoletta Rizzi & Nina Henriette Uhlenhaut & Adriana Maggi, 2021. "Dietary essential amino acids restore liver metabolism in ovariectomized mice via hepatic estrogen receptor α," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-27272-x
    DOI: 10.1038/s41467-021-27272-x
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