IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v5y2014i1d10.1038_ncomms5708.html
   My bibliography  Save this article

A metabolic view on menopause and ageing

Author

Listed:
  • Kirsi Auro

    (Public Health Genomics Unit, National Institute for Health and Welfare
    Institute for Molecular Medicine (FIMM), University of Helsinki
    Helsinki University Central Hospital and University of Helsinki)

  • Anni Joensuu

    (Public Health Genomics Unit, National Institute for Health and Welfare
    Institute for Molecular Medicine (FIMM), University of Helsinki)

  • Krista Fischer

    (Estonian Genome Center, University of Tartu)

  • Johannes Kettunen

    (Public Health Genomics Unit, National Institute for Health and Welfare
    Institute for Molecular Medicine (FIMM), University of Helsinki
    Computational Medicine, Institute of Health Sciences, University of Oulu)

  • Perttu Salo

    (Public Health Genomics Unit, National Institute for Health and Welfare
    Institute for Molecular Medicine (FIMM), University of Helsinki)

  • Hannele Mattsson

    (Public Health Genomics Unit, National Institute for Health and Welfare
    Institute for Molecular Medicine (FIMM), University of Helsinki)

  • Marjo Niironen

    (Public Health Genomics Unit, National Institute for Health and Welfare)

  • Jaakko Kaprio

    (Institute for Molecular Medicine (FIMM), University of Helsinki
    Hjelt Institute, University of Helsinki
    National Institute for Health and Welfare)

  • Johan G. Eriksson

    (Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare
    University of Helsinki
    Vasa Central Hospital
    Folkhälsan Research Centre, Helsingfors Universitet)

  • Terho Lehtimäki

    (Fimlab Laboratories, University of Tampere School of Medicine, Tampere University)

  • Olli Raitakari

    (Research Centre of Applied and Preventive Cardiovascular Medicine, Turku University Hospital, University of Turku)

  • Antti Jula

    (Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare)

  • Aila Tiitinen

    (Helsinki University Central Hospital and University of Helsinki)

  • Matti Jauhiainen

    (Public Health Genomics Unit, National Institute for Health and Welfare
    Institute for Molecular Medicine (FIMM), University of Helsinki)

  • Pasi Soininen

    (Computational Medicine, Institute of Health Sciences, University of Oulu
    NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland)

  • Antti J. Kangas

    (Computational Medicine, Institute of Health Sciences, University of Oulu
    NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland)

  • Mika Kähönen

    (Tampere University Hospital and University of Tampere School of Medicine, Tampere University)

  • Aki S. Havulinna

    (Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare)

  • Mika Ala-Korpela

    (Computational Medicine, Institute of Health Sciences, University of Oulu
    NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland
    Oulu University Hospital
    Computational Medicine, School of Social and Community Medicine and Medical Research Council Integrative Epidemiology Unit, University of Bristol)

  • Veikko Salomaa

    (Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare)

  • Andres Metspalu

    (Estonian Genome Center, University of Tartu)

  • Markus Perola

    (Public Health Genomics Unit, National Institute for Health and Welfare
    Institute for Molecular Medicine (FIMM), University of Helsinki
    Estonian Genome Center, University of Tartu)

Abstract

The ageing of the global population calls for a better understanding of age-related metabolic consequences. Here we report the effects of age, sex and menopause on serum metabolites in 26,065 individuals of Northern European ancestry. Age-specific metabolic fingerprints differ significantly by gender and, in females, a substantial atherogenic shift overlapping the time of menopausal transition is observed. In meta-analysis of 10,083 women, menopause status associates with amino acids glutamine, tyrosine and isoleucine, along with serum cholesterol measures and atherogenic lipoproteins. Among 3,204 women aged 40–55 years, menopause status associates additionally with glycine and total, monounsaturated, and omega-7 and -9 fatty acids. Our findings suggest that, in addition to lipid alterations, menopause may contribute to future metabolic and cardiovascular risk via influencing amino-acid concentrations, adding to the growing evidence of the importance of amino acids in metabolic disease progression. These observations shed light on the metabolic consequences of ageing, gender and menopause at the population level.

Suggested Citation

  • Kirsi Auro & Anni Joensuu & Krista Fischer & Johannes Kettunen & Perttu Salo & Hannele Mattsson & Marjo Niironen & Jaakko Kaprio & Johan G. Eriksson & Terho Lehtimäki & Olli Raitakari & Antti Jula & A, 2014. "A metabolic view on menopause and ageing," Nature Communications, Nature, vol. 5(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms5708
    DOI: 10.1038/ncomms5708
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms5708
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms5708?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Gemma L. Clayton & Maria Carolina Borges & Deborah A. Lawlor, 2024. "The impact of reproductive factors on the metabolic profile of females from menarche to menopause," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Manuela J Rist & Alexander Roth & Lara Frommherz & Christoph H Weinert & Ralf Krüger & Benedikt Merz & Diana Bunzel & Carina Mack & Björn Egert & Achim Bub & Benjamin Görling & Pavleta Tzvetkova & Bur, 2017. "Metabolite patterns predicting sex and age in participants of the Karlsruhe Metabolomics and Nutrition (KarMeN) study," PLOS ONE, Public Library of Science, vol. 12(8), pages 1-21, August.
    3. Sara Della Torre & Valeria Benedusi & Giovanna Pepe & Clara Meda & Nicoletta Rizzi & Nina Henriette Uhlenhaut & Adriana Maggi, 2021. "Dietary essential amino acids restore liver metabolism in ovariectomized mice via hepatic estrogen receptor α," Nature Communications, Nature, vol. 12(1), pages 1-13, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms5708. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.