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Dysbiosis of human gut microbiome in young-onset colorectal cancer

Author

Listed:
  • Yongzhi Yang

    (Fudan University Shanghai Cancer Center
    Fudan University)

  • Lutao Du

    (The Second Hospital of Shandong University)

  • Debing Shi

    (Fudan University Shanghai Cancer Center
    Fudan University)

  • Cheng Kong

    (Shanghai Tenth People’s Hospital Affiliated to Tongji University)

  • Jianqiang Liu

    (Fudan University Shanghai Cancer Center)

  • Guang Liu

    (Quantum Hi-Tech Microecological Medical (Guangdong) Co.,Ltd.)

  • Xinxiang Li

    (Fudan University Shanghai Cancer Center
    Fudan University)

  • Yanlei Ma

    (Fudan University Shanghai Cancer Center
    Fudan University)

Abstract

The incidence of sporadic young-onset colorectal cancer (yCRC) is increasing. A significant knowledge gap exists in the gut microbiota and its diagnostic value for yCRC patients. Through 16S rRNA gene sequencing, 728 samples are collected to identify microbial markers, and an independent cohort of 310 samples is used to validate the results. Furthermore, species-level and functional analysis are performed by metagenome sequencing using 200 samples. Gut microbial diversity is increased in yCRC. Flavonifractor plautii is an important bacterial species in yCRC, while genus Streptococcus contains the key phylotype in the old-onset colorectal cancer. Functional analysis reveals that yCRC has unique characteristics of bacterial metabolism characterized by the dominance of DNA binding and RNA-dependent DNA biosynthetic process. The random forest classifier model achieves a powerful classification potential. This study highlights the potential of the gut microbiota biomarkers as a promising non-invasive tool for the accurate detection and distinction of individuals with yCRC.

Suggested Citation

  • Yongzhi Yang & Lutao Du & Debing Shi & Cheng Kong & Jianqiang Liu & Guang Liu & Xinxiang Li & Yanlei Ma, 2021. "Dysbiosis of human gut microbiome in young-onset colorectal cancer," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-27112-y
    DOI: 10.1038/s41467-021-27112-y
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    References listed on IDEAS

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    1. Kate L. Bowerman & Saima Firdous Rehman & Annalicia Vaughan & Nancy Lachner & Kurtis F. Budden & Richard Y. Kim & David L. A. Wood & Shaan L. Gellatly & Shakti D. Shukla & Lisa G. Wood & Ian A. Yang &, 2020. "Disease-associated gut microbiome and metabolome changes in patients with chronic obstructive pulmonary disease," Nature Communications, Nature, vol. 11(1), pages 1-15, December.
    2. Geicho Nakatsu & Xiangchun Li & Haokui Zhou & Jianqiu Sheng & Sunny Hei Wong & William Ka Kai Wu & Siew Chien Ng & Ho Tsoi & Yujuan Dong & Ning Zhang & Yuqi He & Qian Kang & Lei Cao & Kunning Wang & J, 2015. "Gut mucosal microbiome across stages of colorectal carcinogenesis," Nature Communications, Nature, vol. 6(1), pages 1-9, December.
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    Cited by:

    1. Youwen Qin & Xin Tong & Wei-Jian Mei & Yanshuang Cheng & Yuanqiang Zou & Kai Han & Jiehai Yu & Zhuye Jie & Tao Zhang & Shida Zhu & Xin Jin & Jian Wang & Huanming Yang & Xun Xu & Huanzi Zhong & Liang X, 2024. "Consistent signatures in the human gut microbiome of old- and young-onset colorectal cancer," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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