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Clec4A4 is a regulatory receptor for dendritic cells that impairs inflammation and T-cell immunity

Author

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  • Tomofumi Uto

    (Faculty of Medicine, University of Miyazaki)

  • Tomohiro Fukaya

    (Faculty of Medicine, University of Miyazaki)

  • Hideaki Takagi

    (Faculty of Medicine, University of Miyazaki)

  • Keiichi Arimura

    (Faculty of Medicine, University of Miyazaki
    Faculty of Medicine, University of Miyazaki)

  • Takeshi Nakamura

    (Faculty of Medicine, University of Miyazaki
    Head and Neck Surgery, Faculty of Medicine, University of Miyazaki)

  • Naoya Kojima

    (Tokai University)

  • Bernard Malissen

    (Centre d'Immunologie de Marseille-Luminy, Université de la Méditerrannée, Case 906, Institut National de la Santé et de la Recherche Médicale U631, and Centre National de la Recherche Scientifique UMR6102)

  • Katsuaki Sato

    (Faculty of Medicine, University of Miyazaki
    Japan Science and Technology Agency, Precursory Research for Embryonic Science and Technology (PRESTO))

Abstract

Dendritic cells (DCs) comprise several subsets that are critically involved in the initiation and regulation of immunity. Clec4A4/DC immunoreceptor 2 (DCIR2) is a C-type lectin receptor (CLR) exclusively expressed on CD8α− conventional DCs (cDCs). However, how Clec4A4 controls immune responses through regulation of the function of CD8α− cDCs remains unclear. Here we show that Clec4A4 is a regulatory receptor for the activation of CD8α− cDCs that impairs inflammation and T-cell immunity. Clec4a4−/−CD8α− cDCs show enhanced cytokine production and T-cell priming following Toll-like receptor (TLR)-mediated activation. Furthermore, Clec4a4−/− mice exhibit TLR-mediated hyperinflammation. On antigenic immunization, Clec4a4−/− mice show not only augmented T-cell responses but also progressive autoimmune pathogenesis. Conversely, Clec4a4−/− mice exhibit resistance to microbial infection, accompanied by enhanced T-cell responses against microbes. Thus, our findings highlight roles of Clec4A4 in regulation of the function of CD8α− cDCs for control of the magnitude and quality of immune response.

Suggested Citation

  • Tomofumi Uto & Tomohiro Fukaya & Hideaki Takagi & Keiichi Arimura & Takeshi Nakamura & Naoya Kojima & Bernard Malissen & Katsuaki Sato, 2016. "Clec4A4 is a regulatory receptor for dendritic cells that impairs inflammation and T-cell immunity," Nature Communications, Nature, vol. 7(1), pages 1-15, September.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms11273
    DOI: 10.1038/ncomms11273
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    Cited by:

    1. Stephan M. Tirier & Jan-Philipp Mallm & Simon Steiger & Alexandra M. Poos & Mohamed H. S. Awwad & Nicola Giesen & Nicola Casiraghi & Hana Susak & Katharina Bauer & Anja Baumann & Lukas John & Anja Sec, 2021. "Subclone-specific microenvironmental impact and drug response in refractory multiple myeloma revealed by single‐cell transcriptomics," Nature Communications, Nature, vol. 12(1), pages 1-16, December.

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