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Type VI secretion system mutations reduced competitive fitness of classical Vibrio cholerae biotype

Author

Listed:
  • Benjamin Kostiuk

    (University of Alberta)

  • Francis J. Santoriello

    (University of Colorado Denver Anschutz Medical Campus)

  • Laura Diaz-Satizabal

    (University of Alberta)

  • Fabiana Bisaro

    (The City College of New York)

  • Kyung-Jo Lee

    (The City College of New York)

  • Anna N. Dhody

    (The College of Physicians of Philadelphia)

  • Daniele Provenzano

    (University of Texas Rio Grande Valley, One West University Blvd)

  • Daniel Unterweger

    (Max-Planck Institute for Evolutionary Biology
    Kiel University)

  • Stefan Pukatzki

    (The City College of New York)

Abstract

The gram-negative bacterium Vibrio cholerae is the causative agent of the diarrhoeal disease cholera and is responsible for seven recorded pandemics. Several factors are postulated to have led to the decline of 6th pandemic classical strains and the rise of El Tor biotype V. cholerae, establishing the current 7th pandemic. We investigated the ability of classical V. cholerae of the 2nd and 6th pandemics to engage their type six secretion system (T6SS) in microbial competition against non-pandemic and 7th pandemic strains. We report that classical V. cholerae underwent sequential mutations in T6SS genetic determinants that initially exposed 2nd pandemic strains to microbial attack by non-pandemic strains and subsequently caused 6th pandemic strains to become vulnerable to El Tor biotype V. cholerae intraspecific competition. The chronology of these T6SS-debilitating mutations agrees with the decline of 6th pandemic classical strains and the emergence of 7th pandemic El Tor V. cholerae.

Suggested Citation

  • Benjamin Kostiuk & Francis J. Santoriello & Laura Diaz-Satizabal & Fabiana Bisaro & Kyung-Jo Lee & Anna N. Dhody & Daniele Provenzano & Daniel Unterweger & Stefan Pukatzki, 2021. "Type VI secretion system mutations reduced competitive fitness of classical Vibrio cholerae biotype," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-26847-y
    DOI: 10.1038/s41467-021-26847-y
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    References listed on IDEAS

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    1. Eric Durand & Van Son Nguyen & Abdelrahim Zoued & Laureen Logger & Gérard Péhau-Arnaudet & Marie-Stéphanie Aschtgen & Silvia Spinelli & Aline Desmyter & Benjamin Bardiaux & Annick Dujeancourt & Alain , 2015. "Biogenesis and structure of a type VI secretion membrane core complex," Nature, Nature, vol. 523(7562), pages 555-560, July.
    2. Daniel Unterweger & Sarah T. Miyata & Verena Bachmann & Teresa M. Brooks & Travis Mullins & Benjamin Kostiuk & Daniele Provenzano & Stefan Pukatzki, 2014. "The Vibrio cholerae type VI secretion system employs diverse effector modules for intraspecific competition," Nature Communications, Nature, vol. 5(1), pages 1-9, May.
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