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The Vibrio cholerae type VI secretion system employs diverse effector modules for intraspecific competition

Author

Listed:
  • Daniel Unterweger

    (University of Alberta)

  • Sarah T. Miyata

    (University of Alberta)

  • Verena Bachmann

    (University of Alberta)

  • Teresa M. Brooks

    (University of Alberta)

  • Travis Mullins

    (University of Alberta)

  • Benjamin Kostiuk

    (University of Alberta)

  • Daniele Provenzano

    (University of Texas Brownsville
    University of Texas Brownsville)

  • Stefan Pukatzki

    (University of Alberta)

Abstract

Vibrio cholerae is a Gram-negative bacterial pathogen that consists of over 200 serogroups with differing pathogenic potential. Only strains that express the virulence factors cholera toxin (CT) and toxin-coregulated pilus (TCP) are capable of pandemic spread of cholera diarrhoea. Regardless, all V. cholerae strains sequenced to date harbour genes for the type VI secretion system (T6SS) that translocates effectors into neighbouring eukaryotic and prokaryotic cells. Here we report that the effectors encoded within these conserved gene clusters differ widely among V. cholerae strains, and that immunity proteins encoded immediately downstream from the effector genes protect their host from neighbouring bacteria producing corresponding effectors. As a consequence, strains with matching effector-immunity gene sets can coexist, while strains with different sets compete against each other. Thus, the V. cholerae T6SS contributes to the competitive behaviour of this species.

Suggested Citation

  • Daniel Unterweger & Sarah T. Miyata & Verena Bachmann & Teresa M. Brooks & Travis Mullins & Benjamin Kostiuk & Daniele Provenzano & Stefan Pukatzki, 2014. "The Vibrio cholerae type VI secretion system employs diverse effector modules for intraspecific competition," Nature Communications, Nature, vol. 5(1), pages 1-9, May.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms4549
    DOI: 10.1038/ncomms4549
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    Cited by:

    1. Benjamin Kostiuk & Francis J. Santoriello & Laura Diaz-Satizabal & Fabiana Bisaro & Kyung-Jo Lee & Anna N. Dhody & Daniele Provenzano & Daniel Unterweger & Stefan Pukatzki, 2021. "Type VI secretion system mutations reduced competitive fitness of classical Vibrio cholerae biotype," Nature Communications, Nature, vol. 12(1), pages 1-11, December.

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