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A three-tiered colloidosomal microreactor for continuous flow catalysis

Author

Listed:
  • Hua Wu

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Xuanlin Du

    (Chinese Academy of Sciences)

  • Xiaohui Meng

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Dong Qiu

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Yan Qiao

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

Abstract

Integrative colloidosomes with hierarchical structure and advanced function may serve as biomimetic microreactors to carry out catalytic reactions by compartmentalizing biological species within semipermeable membranes. Despite of recent progress in colloidosome design, integration of biological and inorganic components into tiered structures to tackle the remaining challenges of biocatalysis is highly demanded. Here, we report a rational design of three-tiered colloidosomes via the Pickering emulsion process. The microreactor consists of crosslinked amphiphilic silica-polymer hybrid nanoparticles as the semipermeable shell, an enzyme-incorporated catalytic sub-layer, and a partially-silicified adsorptive lumen. By leveraging confinement and enrichment effect, we demonstrate the acceleration of lipase-catalyzed ester hydrolysis within the microcompartment of organic-inorganic hybrid colloidosomes. The catalytic colloidosomes are further assembled into a closely packed column for enzymatic reactions in a continuous flow format with enhanced reaction rates. The three-tiered colloidosomes provide a reliable platform to integrate functional building blocks into a biomimetic compartmentalized microreactor with spatially controlled organization and high-performance functions.

Suggested Citation

  • Hua Wu & Xuanlin Du & Xiaohui Meng & Dong Qiu & Yan Qiao, 2021. "A three-tiered colloidosomal microreactor for continuous flow catalysis," Nature Communications, Nature, vol. 12(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-26381-x
    DOI: 10.1038/s41467-021-26381-x
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