IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v11y2020i1d10.1038_s41467-019-13759-1.html
   My bibliography  Save this article

Catalytic processing in ruthenium-based polyoxometalate coacervate protocells

Author

Listed:
  • Pierangelo Gobbo

    (University of Bristol)

  • Liangfei Tian

    (University of Bristol)

  • B. V. V. S Pavan Kumar

    (University of Bristol)

  • Samuel Turvey

    (University of Bristol)

  • Mattia Cattelan

    (University of Bristol)

  • Avinash J. Patil

    (University of Bristol)

  • Mauro Carraro

    (Università di Padova)

  • Marcella Bonchio

    (Università di Padova)

  • Stephen Mann

    (University of Bristol)

Abstract

The development of programmable microscale materials with cell-like functions, dynamics and collective behaviour is an important milestone in systems chemistry, soft matter bioengineering and synthetic protobiology. Here, polymer/nucleotide coacervate micro-droplets are reconfigured into membrane-bounded polyoxometalate coacervate vesicles (PCVs) in the presence of a bio-inspired Ru-based polyoxometalate catalyst to produce synzyme protocells (Ru4PCVs) with catalase-like activity. We exploit the synthetic protocells for the implementation of multi-compartmentalized cell-like models capable of collective synzyme-mediated buoyancy, parallel catalytic processing in individual horseradish peroxidase-containing Ru4PCVs, and chemical signalling in distributed or encapsulated multi-catalytic protocell communities. Our results highlight a new type of catalytic micro-compartment with multi-functional activity and provide a step towards the development of protocell reaction networks.

Suggested Citation

  • Pierangelo Gobbo & Liangfei Tian & B. V. V. S Pavan Kumar & Samuel Turvey & Mattia Cattelan & Avinash J. Patil & Mauro Carraro & Marcella Bonchio & Stephen Mann, 2020. "Catalytic processing in ruthenium-based polyoxometalate coacervate protocells," Nature Communications, Nature, vol. 11(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-019-13759-1
    DOI: 10.1038/s41467-019-13759-1
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-019-13759-1
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-019-13759-1?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Shoupeng Cao & Tsvetomir Ivanov & Julian Heuer & Calum T. J. Ferguson & Katharina Landfester & Lucas Caire da Silva, 2024. "Dipeptide coacervates as artificial membraneless organelles for bioorthogonal catalysis," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    2. Songyang Liu & Yanwen Zhang & Xiaoxiao He & Mei Li & Jin Huang & Xiaohai Yang & Kemin Wang & Stephen Mann & Jianbo Liu, 2022. "Signal processing and generation of bioactive nitric oxide in a model prototissue," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    3. Hua Wu & Xuanlin Du & Xiaohui Meng & Dong Qiu & Yan Qiao, 2021. "A three-tiered colloidosomal microreactor for continuous flow catalysis," Nature Communications, Nature, vol. 12(1), pages 1-8, December.
    4. Youping Lin & Haixu Chen & Lei Wang & Jiaojiao Su & Junbo Li & Xin Huang, 2024. "Lipase activated endocytosis-like behavior of oil-in-water emulsion," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-019-13759-1. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.