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Catalytic processing in ruthenium-based polyoxometalate coacervate protocells

Author

Listed:
  • Pierangelo Gobbo

    (University of Bristol)

  • Liangfei Tian

    (University of Bristol)

  • B. V. V. S Pavan Kumar

    (University of Bristol)

  • Samuel Turvey

    (University of Bristol)

  • Mattia Cattelan

    (University of Bristol)

  • Avinash J. Patil

    (University of Bristol)

  • Mauro Carraro

    (Università di Padova)

  • Marcella Bonchio

    (Università di Padova)

  • Stephen Mann

    (University of Bristol)

Abstract

The development of programmable microscale materials with cell-like functions, dynamics and collective behaviour is an important milestone in systems chemistry, soft matter bioengineering and synthetic protobiology. Here, polymer/nucleotide coacervate micro-droplets are reconfigured into membrane-bounded polyoxometalate coacervate vesicles (PCVs) in the presence of a bio-inspired Ru-based polyoxometalate catalyst to produce synzyme protocells (Ru4PCVs) with catalase-like activity. We exploit the synthetic protocells for the implementation of multi-compartmentalized cell-like models capable of collective synzyme-mediated buoyancy, parallel catalytic processing in individual horseradish peroxidase-containing Ru4PCVs, and chemical signalling in distributed or encapsulated multi-catalytic protocell communities. Our results highlight a new type of catalytic micro-compartment with multi-functional activity and provide a step towards the development of protocell reaction networks.

Suggested Citation

  • Pierangelo Gobbo & Liangfei Tian & B. V. V. S Pavan Kumar & Samuel Turvey & Mattia Cattelan & Avinash J. Patil & Mauro Carraro & Marcella Bonchio & Stephen Mann, 2020. "Catalytic processing in ruthenium-based polyoxometalate coacervate protocells," Nature Communications, Nature, vol. 11(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-019-13759-1
    DOI: 10.1038/s41467-019-13759-1
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    Cited by:

    1. Shoupeng Cao & Tsvetomir Ivanov & Julian Heuer & Calum T. J. Ferguson & Katharina Landfester & Lucas Caire da Silva, 2024. "Dipeptide coacervates as artificial membraneless organelles for bioorthogonal catalysis," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    2. Songyang Liu & Yanwen Zhang & Xiaoxiao He & Mei Li & Jin Huang & Xiaohai Yang & Kemin Wang & Stephen Mann & Jianbo Liu, 2022. "Signal processing and generation of bioactive nitric oxide in a model prototissue," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    3. Hua Wu & Xuanlin Du & Xiaohui Meng & Dong Qiu & Yan Qiao, 2021. "A three-tiered colloidosomal microreactor for continuous flow catalysis," Nature Communications, Nature, vol. 12(1), pages 1-8, December.

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