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Vacancies on 2D transition metal dichalcogenides elicit ferroptotic cell death

Author

Listed:
  • Shujuan Xu

    (Soochow University)

  • Huizhen Zheng

    (Soochow University)

  • Ronglin Ma

    (Soochow University)

  • Di Wu

    (Soochow University)

  • Yanxia Pan

    (Soochow University)

  • Chunyang Yin

    (State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences)

  • Meng Gao

    (Soochow University)

  • Weili Wang

    (Soochow University)

  • Wei Li

    (Soochow University)

  • Sijin Liu

    (State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences)

  • Zhifang Chai

    (Soochow University)

  • Ruibin Li

    (Soochow University)

Abstract

Sustainable developments of nanotechnology necessitate the exploration of structure-activity relationships (SARs) at nano-bio interfaces. While ferroptosis may contribute in the developments of some severe diseases (e.g., Parkinson’s disease, stroke and tumors), the cellular pathways and nano-SARs are rarely explored in diseases elicited by nano-sized ferroptosis inducers. Here we find that WS2 and MoS2 nanosheets induce an iron-dependent cell death, ferroptosis in epithelial (BEAS-2B) and macrophage (THP-1) cells, evidenced by the suppression of glutathione peroxidase 4 (GPX4), oxygen radical generation and lipid peroxidation. Notably, nano-SAR analysis of 20 transition metal dichalcogenides (TMDs) disclosures the decisive role of surface vacancy in ferroptosis. We therefore develop methanol and sulfide passivation as safe design approaches for TMD nanosheets. These findings are validated in animal lungs by oropharyngeal aspiration of TMD nanosheets. Overall, our study highlights the key cellular events as well as nano-SARs in TMD-induced ferroptosis, which may facilitate the safe design of nanoproducts.

Suggested Citation

  • Shujuan Xu & Huizhen Zheng & Ronglin Ma & Di Wu & Yanxia Pan & Chunyang Yin & Meng Gao & Weili Wang & Wei Li & Sijin Liu & Zhifang Chai & Ruibin Li, 2020. "Vacancies on 2D transition metal dichalcogenides elicit ferroptotic cell death," Nature Communications, Nature, vol. 11(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-17300-7
    DOI: 10.1038/s41467-020-17300-7
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    References listed on IDEAS

    as
    1. Alberto Ciarrocchi & Ahmet Avsar & Dmitry Ovchinnikov & Andras Kis, 2018. "Thickness-modulated metal-to-semiconductor transformation in a transition metal dichalcogenide," Nature Communications, Nature, vol. 9(1), pages 1-6, December.
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    Cited by:

    1. Jun Jiang & Lili Yang & Qianqian Xie & Xi Liu & Jie Jiang & Jie Zhang & Shuping Zhang & Huizhen Zheng & Wenjie Li & Xiaoming Cai & Sijin Liu & Ruibin Li, 2024. "Synthetic vectors for activating the driving axis of ferroptosis," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    2. Weili Wang & Huizhen Zheng & Jun Jiang & Zhi Li & Dongpeng Jiang & Xiangru Shi & Hui Wang & Jie Jiang & Qianqian Xie & Meng Gao & Jianhong Chu & Xiaoming Cai & Tian Xia & Ruibin Li, 2022. "Engineering micro oxygen factories to slow tumour progression via hyperoxic microenvironments," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    3. Da-Yong Hou & Dong-Bing Cheng & Ni-Yuan Zhang & Zhi-Jia Wang & Xing-Jie Hu & Xin Li & Mei-Yu Lv & Xiang-Peng Li & Ling-Rui Jian & Jin-Peng Ma & Taolei Sun & Zeng-Ying Qiao & Wanhai Xu & Hao Wang, 2024. "In vivo assembly enhanced binding effect augments tumor specific ferroptosis therapy," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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