IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v11y2020i1d10.1038_s41467-020-17300-7.html
   My bibliography  Save this article

Vacancies on 2D transition metal dichalcogenides elicit ferroptotic cell death

Author

Listed:
  • Shujuan Xu

    (Soochow University)

  • Huizhen Zheng

    (Soochow University)

  • Ronglin Ma

    (Soochow University)

  • Di Wu

    (Soochow University)

  • Yanxia Pan

    (Soochow University)

  • Chunyang Yin

    (State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences)

  • Meng Gao

    (Soochow University)

  • Weili Wang

    (Soochow University)

  • Wei Li

    (Soochow University)

  • Sijin Liu

    (State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences)

  • Zhifang Chai

    (Soochow University)

  • Ruibin Li

    (Soochow University)

Abstract

Sustainable developments of nanotechnology necessitate the exploration of structure-activity relationships (SARs) at nano-bio interfaces. While ferroptosis may contribute in the developments of some severe diseases (e.g., Parkinson’s disease, stroke and tumors), the cellular pathways and nano-SARs are rarely explored in diseases elicited by nano-sized ferroptosis inducers. Here we find that WS2 and MoS2 nanosheets induce an iron-dependent cell death, ferroptosis in epithelial (BEAS-2B) and macrophage (THP-1) cells, evidenced by the suppression of glutathione peroxidase 4 (GPX4), oxygen radical generation and lipid peroxidation. Notably, nano-SAR analysis of 20 transition metal dichalcogenides (TMDs) disclosures the decisive role of surface vacancy in ferroptosis. We therefore develop methanol and sulfide passivation as safe design approaches for TMD nanosheets. These findings are validated in animal lungs by oropharyngeal aspiration of TMD nanosheets. Overall, our study highlights the key cellular events as well as nano-SARs in TMD-induced ferroptosis, which may facilitate the safe design of nanoproducts.

Suggested Citation

  • Shujuan Xu & Huizhen Zheng & Ronglin Ma & Di Wu & Yanxia Pan & Chunyang Yin & Meng Gao & Weili Wang & Wei Li & Sijin Liu & Zhifang Chai & Ruibin Li, 2020. "Vacancies on 2D transition metal dichalcogenides elicit ferroptotic cell death," Nature Communications, Nature, vol. 11(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-17300-7
    DOI: 10.1038/s41467-020-17300-7
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-020-17300-7
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-020-17300-7?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Alberto Ciarrocchi & Ahmet Avsar & Dmitry Ovchinnikov & Andras Kis, 2018. "Thickness-modulated metal-to-semiconductor transformation in a transition metal dichalcogenide," Nature Communications, Nature, vol. 9(1), pages 1-6, December.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Jun Jiang & Lili Yang & Qianqian Xie & Xi Liu & Jie Jiang & Jie Zhang & Shuping Zhang & Huizhen Zheng & Wenjie Li & Xiaoming Cai & Sijin Liu & Ruibin Li, 2024. "Synthetic vectors for activating the driving axis of ferroptosis," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    2. Weili Wang & Huizhen Zheng & Jun Jiang & Zhi Li & Dongpeng Jiang & Xiangru Shi & Hui Wang & Jie Jiang & Qianqian Xie & Meng Gao & Jianhong Chu & Xiaoming Cai & Tian Xia & Ruibin Li, 2022. "Engineering micro oxygen factories to slow tumour progression via hyperoxic microenvironments," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    3. Da-Yong Hou & Dong-Bing Cheng & Ni-Yuan Zhang & Zhi-Jia Wang & Xing-Jie Hu & Xin Li & Mei-Yu Lv & Xiang-Peng Li & Ling-Rui Jian & Jin-Peng Ma & Taolei Sun & Zeng-Ying Qiao & Wanhai Xu & Hao Wang, 2024. "In vivo assembly enhanced binding effect augments tumor specific ferroptosis therapy," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Xinyu Chen & Yufeng Xie & Yaochen Sheng & Hongwei Tang & Zeming Wang & Yu Wang & Yin Wang & Fuyou Liao & Jingyi Ma & Xiaojiao Guo & Ling Tong & Hanqi Liu & Hao Liu & Tianxiang Wu & Jiaxin Cao & Sitong, 2021. "Wafer-scale functional circuits based on two dimensional semiconductors with fabrication optimized by machine learning," Nature Communications, Nature, vol. 12(1), pages 1-8, December.
    2. Lijie Chen & Weitao Zhang & Hanlin Zhang & Jiawang Chen & Chaoyang Tan & Shiqi Yin & Gang Li & Yu Zhang & Penglai Gong & Liang Li, 2021. "In-Plane Anisotropic Thermal Conductivity of Low-Symmetry PdSe 2," Sustainability, MDPI, vol. 13(8), pages 1-10, April.
    3. Lutao Li & Junjie Yao & Juntong Zhu & Yuan Chen & Chen Wang & Zhicheng Zhou & Guoxiang Zhao & Sihan Zhang & Ruonan Wang & Jiating Li & Xiangyi Wang & Zheng Lu & Lingbo Xiao & Qiang Zhang & Guifu Zou, 2023. "Colloid driven low supersaturation crystallization for atomically thin Bismuth halide perovskite," Nature Communications, Nature, vol. 14(1), pages 1-8, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-17300-7. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.