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Engineering micro oxygen factories to slow tumour progression via hyperoxic microenvironments

Author

Listed:
  • Weili Wang

    (Soochow University)

  • Huizhen Zheng

    (Soochow University)

  • Jun Jiang

    (Soochow University)

  • Zhi Li

    (Soochow University)

  • Dongpeng Jiang

    (Soochow University)

  • Xiangru Shi

    (Soochow University)

  • Hui Wang

    (Soochow University)

  • Jie Jiang

    (Soochow University)

  • Qianqian Xie

    (Soochow University)

  • Meng Gao

    (Soochow University)

  • Jianhong Chu

    (Soochow University)

  • Xiaoming Cai

    (Soochow University)

  • Tian Xia

    (University of California)

  • Ruibin Li

    (Soochow University)

Abstract

While hypoxia promotes carcinogenesis, tumour aggressiveness, metastasis, and resistance to oncological treatments, the impacts of hyperoxia on tumours are rarely explored because providing a long-lasting oxygen supply in vivo is a major challenge. Herein, we construct micro oxygen factories, namely, photosynthesis microcapsules (PMCs), by encapsulation of acquired cyanobacteria and upconversion nanoparticles in alginate microcapsules. This system enables a long-lasting oxygen supply through the conversion of external radiation into red-wavelength emissions for photosynthesis in cyanobacteria. PMC treatment suppresses the NF-kB pathway, HIF-1α production and cancer cell proliferation. Hyperoxic microenvironment created by an in vivo PMC implant inhibits hepatocarcinoma growth and metastasis and has synergistic effects together with anti-PD-1 in breast cancer. The engineering oxygen factories offer potential for tumour biology studies in hyperoxic microenvironments and inspire the exploration of oncological treatments.

Suggested Citation

  • Weili Wang & Huizhen Zheng & Jun Jiang & Zhi Li & Dongpeng Jiang & Xiangru Shi & Hui Wang & Jie Jiang & Qianqian Xie & Meng Gao & Jianhong Chu & Xiaoming Cai & Tian Xia & Ruibin Li, 2022. "Engineering micro oxygen factories to slow tumour progression via hyperoxic microenvironments," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
  • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32066-w
    DOI: 10.1038/s41467-022-32066-w
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    1. Jun Jiang & Lili Yang & Qianqian Xie & Xi Liu & Jie Jiang & Jie Zhang & Shuping Zhang & Huizhen Zheng & Wenjie Li & Xiaoming Cai & Sijin Liu & Ruibin Li, 2024. "Synthetic vectors for activating the driving axis of ferroptosis," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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