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Biointerfacial self-assembly generates lipid membrane coated bacteria for enhanced oral delivery and treatment

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  • Zhenping Cao

    (Shanghai Jiao Tong University)

  • Xinyue Wang

    (Shanghai Jiao Tong University)

  • Yan Pang

    (Shanghai Jiao Tong University)

  • Shanshan Cheng

    (Shanghai Jiao Tong University)

  • Jinyao Liu

    (Shanghai Jiao Tong University)

Abstract

The gut microbiota represents a huge community of microorganisms that play essential roles in immune modulation and homeostasis maintenance. Microbiota transplantation is an important approach to prevent and treat disease as it can inhibit pathogen colonization and positively modulate bacterial composition. However, the development of oral bacterial therapeutics has been restricted by low bioavailability and limited retention in the gastrointestinal tract. Here, we report a simple yet highly efficient method to coat gut microbes via biointerfacial supramolecular self-assembly. Coating can be performed within 15 min by simply vortexing with biocompatible lipids. Bacteria coated with an extra self-assembled lipid membrane exhibit significantly improved survival against environmental assaults and almost unchanged viability and bioactivity. We demonstrate their enhanced efficacies in oral delivery and treatment using two murine models of colitis. We suggest that biointerfacial supramolecular self-assembly may provide a unique platform to generate advanced bacterial therapeutics for the treatment of various diseases.

Suggested Citation

  • Zhenping Cao & Xinyue Wang & Yan Pang & Shanshan Cheng & Jinyao Liu, 2019. "Biointerfacial self-assembly generates lipid membrane coated bacteria for enhanced oral delivery and treatment," Nature Communications, Nature, vol. 10(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-13727-9
    DOI: 10.1038/s41467-019-13727-9
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    Cited by:

    1. Zhongmin Geng & Zhenping Cao & Rui Liu & Ke Liu & Jinyao Liu & Weihong Tan, 2021. "Aptamer-assisted tumor localization of bacteria for enhanced biotherapy," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    2. Huilong Luo & Yanmei Chen & Xiao Kuang & Xinyue Wang & Fengmin Yang & Zhenping Cao & Lu Wang & Sisi Lin & Feng Wu & Jinyao Liu, 2022. "Chemical reaction-mediated covalent localization of bacteria," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    3. Wenjing Jin & Xianfeng Lin & Haihua Pan & Chenchen Zhao & Pengcheng Qiu & Ruibo Zhao & Zihe Hu & Yanyan Zhou & Haiyan Wu & Xiao Chen & Hongwei Ouyang & Zhijian Xie & Ruikang Tang, 2021. "Engineered osteoclasts as living treatment materials for heterotopic ossification therapy," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    4. Jun Zhou & Maoyi Li & Qiufang Chen & Xinjie Li & Linfu Chen & Ziliang Dong & Wenjun Zhu & Yang Yang & Zhuang Liu & Qian Chen, 2022. "Programmable probiotics modulate inflammation and gut microbiota for inflammatory bowel disease treatment after effective oral delivery," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    5. Mairead K. Heavey & Anthony Hazelton & Yuyan Wang & Mitzy Garner & Aaron C. Anselmo & Janelle C. Arthur & Juliane Nguyen, 2024. "Targeted delivery of the probiotic Saccharomyces boulardii to the extracellular matrix enhances gut residence time and recovery in murine colitis," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    6. Jiezhou Pan & Guidong Gong & Qin Wang & Jiaojiao Shang & Yunxiang He & Chelsea Catania & Dan Birnbaum & Yifei Li & Zhijun Jia & Yaoyao Zhang & Neel S. Joshi & Junling Guo, 2022. "A single-cell nanocoating of probiotics for enhanced amelioration of antibiotic-associated diarrhea," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    7. Xiaotu Ma & Xiaolong Liang & Yao Li & Qingqing Feng & Keman Cheng & Nana Ma & Fei Zhu & Xinjing Guo & Yale Yue & Guangna Liu & Tianjiao Zhang & Jie Liang & Lei Ren & Xiao Zhao & Guangjun Nie, 2023. "Modular-designed engineered bacteria for precision tumor immunotherapy via spatiotemporal manipulation by magnetic field," Nature Communications, Nature, vol. 14(1), pages 1-22, December.

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