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Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates

Author

Listed:
  • Hassan S. Dashti

    (Massachusetts General Hospital and Harvard Medical School
    Broad Institute)

  • Samuel E. Jones

    (University of Exeter Medical School)

  • Andrew R. Wood

    (University of Exeter Medical School)

  • Jacqueline M. Lane

    (Massachusetts General Hospital and Harvard Medical School
    Broad Institute
    Massachusetts General Hospital and Harvard Medical School)

  • Vincent T. Hees

    (Netherlands eScience Center)

  • Heming Wang

    (Broad Institute
    Brigham and Women’s Hospital
    Harvard Medical School)

  • Jessica A. Rhodes

    (Massachusetts General Hospital and Harvard Medical School
    Broad Institute)

  • Yanwei Song

    (Massachusetts General Hospital and Harvard Medical School
    Northeastern University College of Science)

  • Krunal Patel

    (Massachusetts General Hospital and Harvard Medical School
    Northeastern University College of Science)

  • Simon G. Anderson

    (The University of Manchester)

  • Robin N. Beaumont

    (University of Exeter Medical School)

  • David A. Bechtold

    (University of Manchester)

  • Jack Bowden

    (MRC Integrative Epidemiology Unit at the University of Bristol
    University of Bristol)

  • Brian E. Cade

    (Broad Institute
    Brigham and Women’s Hospital
    Harvard Medical School)

  • Marta Garaulet

    (University of Murcia
    IMIB-Arrixaca)

  • Simon D. Kyle

    (University of Oxford)

  • Max A. Little

    (Aston University
    Massachusetts Institute of Technology)

  • Andrew S. Loudon

    (University of Manchester)

  • Annemarie I. Luik

    (University of Oxford)

  • Frank A. J. L. Scheer

    (Broad Institute
    Harvard Medical School
    Brigham and Women’s Hospital)

  • Kai Spiegelhalder

    (University of Freiburg)

  • Jessica Tyrrell

    (University of Exeter Medical School)

  • Daniel J. Gottlieb

    (Brigham and Women’s Hospital
    Harvard Medical School
    VA Boston Healthcare System)

  • Henning Tiemeier

    (Harvard TH Chan School of Public Health
    Erasmus Medical Center)

  • David W. Ray

    (University of Manchester)

  • Shaun M. Purcell

    (Harvard Medical School)

  • Timothy M. Frayling

    (University of Exeter Medical School)

  • Susan Redline

    (Harvard Medical School)

  • Deborah A. Lawlor

    (MRC Integrative Epidemiology Unit at the University of Bristol
    University of Bristol)

  • Martin K. Rutter

    (University of Manchester
    Manchester Academic Health Science Centre)

  • Michael N. Weedon

    (University of Exeter Medical School)

  • Richa Saxena

    (Massachusetts General Hospital and Harvard Medical School
    Broad Institute
    Massachusetts General Hospital and Harvard Medical School)

Abstract

Sleep is an essential state of decreased activity and alertness but molecular factors regulating sleep duration remain unknown. Through genome-wide association analysis in 446,118 adults of European ancestry from the UK Biobank, we identify 78 loci for self-reported habitual sleep duration (p

Suggested Citation

  • Hassan S. Dashti & Samuel E. Jones & Andrew R. Wood & Jacqueline M. Lane & Vincent T. Hees & Heming Wang & Jessica A. Rhodes & Yanwei Song & Krunal Patel & Simon G. Anderson & Robin N. Beaumont & Davi, 2019. "Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates," Nature Communications, Nature, vol. 10(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-08917-4
    DOI: 10.1038/s41467-019-08917-4
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    Cited by:

    1. Isabelle Austin-Zimmerman & Daniel F. Levey & Olga Giannakopoulou & Joseph D. Deak & Marco Galimberti & Keyrun Adhikari & Hang Zhou & Spiros Denaxas & Haritz Irizar & Karoline Kuchenbaecker & Andrew M, 2023. "Genome-wide association studies and cross-population meta-analyses investigating short and long sleep duration," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Matthew C. Pahl & Claudia A. Doege & Kenyaita M. Hodge & Sheridan H. Littleton & Michelle E. Leonard & Sumei Lu & Rick Rausch & James A. Pippin & Maria Caterina Rosa & Alisha Basak & Jonathan P. Bradf, 2021. "Cis-regulatory architecture of human ESC-derived hypothalamic neuron differentiation aids in variant-to-gene mapping of relevant complex traits," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    3. Pengfei Xu & Dazhi Wang & Jianqiao He & Yichang Cui & Liangkun Lu & Yikang Li & Xiangji Chen & Chang Liu & Liujia Suo & Tongqun Ren & Tiesheng Wang & Yan Cui, 2024. "A zinc oxide resonant nano-accelerometer with ultra-high sensitivity," Nature Communications, Nature, vol. 15(1), pages 1-8, December.
    4. Yunhe Wang & Binbin Su & Marta Alcalde-Herraiz & Nicola L. Barclay & Yaohua Tian & Chunxiao Li & Nicholas J. Wareham & Roger Paredes & Junqing Xie & Daniel Prieto-Alhambra, 2024. "Modifiable lifestyle factors and the risk of post-COVID-19 multisystem sequelae, hospitalization, and death," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    5. Anders M. Fjell & Øystein Sørensen & Yunpeng Wang & Inge K. Amlien & William F. C. Baaré & David Bartrés-Faz & Lars Bertram & Carl-Johan Boraxbekk & Andreas M. Brandmaier & Ilja Demuth & Christian A. , 2023. "No phenotypic or genotypic evidence for a link between sleep duration and brain atrophy," Nature Human Behaviour, Nature, vol. 7(11), pages 2008-2022, November.
    6. Jordi Manuello & Joosung Min & Paul McCarthy & Fidel Alfaro-Almagro & Soojin Lee & Stephen Smith & Lloyd T. Elliott & Anderson M. Winkler & Gwenaëlle Douaud, 2024. "The effects of genetic and modifiable risk factors on brain regions vulnerable to ageing and disease," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    7. Maria Niarchou & Daniel E. Gustavson & J. Fah Sathirapongsasuti & Manuel Anglada-Tort & Else Eising & Eamonn Bell & Evonne McArthur & Peter Straub & J. Devin McAuley & John A. Capra & Fredrik Ullén & , 2022. "Genome-wide association study of musical beat synchronization demonstrates high polygenicity," Nature Human Behaviour, Nature, vol. 6(9), pages 1292-1309, September.

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