IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v21y2024i3p284-d1348652.html
   My bibliography  Save this article

HIPTox—Hazard Identification Platform to Assess the Health Impacts from Indoor and Outdoor Air Pollutant Exposures, through Mechanistic Toxicology: A Single-Centre Double-Blind Human Exposure Trial Protocol

Author

Listed:
  • Thomas Faherty

    (School of Geography, Earth and Environmental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    These authors contributed equally to this work.)

  • Huda Badri

    (Division of Infection, Immunity and Respiratory Medicine, University of Manchester, 2nd Floor Education and Research Centre, Wythenshawe Hospital, Southmoor Rd., Manchester M23 9LT, UK
    Manchester University NHS Foundation Trust, Manchester M13 9WL, UK
    These authors contributed equally to this work.)

  • Dawei Hu

    (Centre for Atmospheric Sciences, Department of Earth and Environmental Science, School of Natural Sciences, University of Manchester, Manchester M13 9PL, UK)

  • Aristeidis Voliotis

    (Centre for Atmospheric Sciences, Department of Earth and Environmental Science, School of Natural Sciences, University of Manchester, Manchester M13 9PL, UK
    National Centre for Atmospheric Science, Department of Earth and Environmental Science, University of Manchester, Manchester M13 9PL, UK)

  • Francis D. Pope

    (School of Geography, Earth and Environmental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK)

  • Ian Mudway

    (MRC Centre for Environment and Health, Imperial College London, London W12 0BZ, UK
    NIHR Health Protection Research Unit in Environmental Exposures and Health, Imperial College London, London W12 0BZ, UK
    NIHR Health Protection Research Unit in Chemical and Radiation Threats and Hazards, Imperial College London, London W12 0BZ, UK)

  • Jacky Smith

    (Division of Infection, Immunity and Respiratory Medicine, University of Manchester, 2nd Floor Education and Research Centre, Wythenshawe Hospital, Southmoor Rd., Manchester M23 9LT, UK
    Manchester University NHS Foundation Trust, Manchester M13 9WL, UK)

  • Gordon McFiggans

    (Centre for Atmospheric Sciences, Department of Earth and Environmental Science, School of Natural Sciences, University of Manchester, Manchester M13 9PL, UK)

Abstract

Over the past decade, our understanding of the impact of air pollution on short- and long-term population health has advanced considerably, focusing on adverse effects on cardiovascular and respiratory systems. There is, however, increasing evidence that air pollution exposures affect cognitive function, particularly in susceptible groups. Our study seeks to assess and hazard rank the cognitive effects of prevalent indoor and outdoor pollutants through a single-centre investigation on the cognitive functioning of healthy human volunteers aged 50 and above with a familial predisposition to dementia. Participants will all undertake five sequential controlled exposures. The sources of the air pollution exposures are wood smoke, diesel exhaust, cleaning products, and cooking emissions, with clean air serving as the control. Pre- and post-exposure spirometry, nasal lavage, blood sampling, and cognitive assessments will be performed. Repeated testing pre and post exposure to controlled levels of pollutants will allow for the identification of acute changes in functioning as well as the detection of peripheral markers of neuroinflammation and neuronal toxicity. This comprehensive approach enables the identification of the most hazardous components in indoor and outdoor air pollutants and further understanding of the pathways contributing to neurodegenerative diseases. The results of this project have the potential to facilitate greater refinement in policy, emphasizing health-relevant pollutants and providing details to aid mitigation against pollutant-associated health risks.

Suggested Citation

  • Thomas Faherty & Huda Badri & Dawei Hu & Aristeidis Voliotis & Francis D. Pope & Ian Mudway & Jacky Smith & Gordon McFiggans, 2024. "HIPTox—Hazard Identification Platform to Assess the Health Impacts from Indoor and Outdoor Air Pollutant Exposures, through Mechanistic Toxicology: A Single-Centre Double-Blind Human Exposure Trial Pr," IJERPH, MDPI, vol. 21(3), pages 1-18, February.
    • Handle: RePEc:gam:jijerp:v:21:y:2024:i:3:p:284-:d:1348652
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/21/3/284/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/21/3/284/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Matthew Botvinick & Leigh E. Nystrom & Kate Fissell & Cameron S. Carter & Jonathan D. Cohen, 1999. "Conflict monitoring versus selection-for-action in anterior cingulate cortex," Nature, Nature, vol. 402(6758), pages 179-181, November.
    2. Harvey, Lewis O., 1992. "The critical operating characteristic and the evaluation of expert judgment," Organizational Behavior and Human Decision Processes, Elsevier, vol. 53(2), pages 229-251, November.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Keita Kamijo & Seongryu Bae & Hiroaki Masaki, 2016. "The Association of Childhood Fitness to Proactive and Reactive Action Monitoring," PLOS ONE, Public Library of Science, vol. 11(3), pages 1-13, March.
    2. Samantha Huang & Stephanie Rossi & Matti Hämäläinen & Jyrki Ahveninen, 2014. "Auditory Conflict Resolution Correlates with Medial–Lateral Frontal Theta/Alpha Phase Synchrony," PLOS ONE, Public Library of Science, vol. 9(10), pages 1-13, October.
    3. Ozer, Muammer, 2011. "Understanding the impacts of product knowledge and product type on the accuracy of intentions-based new product predictions," European Journal of Operational Research, Elsevier, vol. 211(2), pages 359-369, June.
    4. James R Schmidt & Daniel H Weissman, 2014. "Congruency Sequence Effects without Feature Integration or Contingency Learning Confounds," PLOS ONE, Public Library of Science, vol. 9(7), pages 1-9, July.
    5. Santarnecchi, Emiliano & Emmendorfer, Alexandra & Pascual-Leone, Alvaro, 2017. "Dissecting the parieto-frontal correlates of fluid intelligence: A comprehensive ALE meta-analysis study," Intelligence, Elsevier, vol. 63(C), pages 9-28.
    6. Santarnecchi, Emiliano & Emmendorfer, Alexandra & Tadayon, Sayedhedayatollah & Rossi, Simone & Rossi, Alessandro & Pascual-Leone, Alvaro, 2017. "Network connectivity correlates of variability in fluid intelligence performance," Intelligence, Elsevier, vol. 65(C), pages 35-47.
    7. Grand, James A. & Golubovich, Juliya & Ryan, Ann Marie & Schmitt, Neal, 2013. "The detection and influence of problematic item content in ability tests: An examination of sensitivity review practices for personnel selection test development," Organizational Behavior and Human Decision Processes, Elsevier, vol. 121(2), pages 158-173.
    8. Samantha J Brooks & Jonathan Cedernaes & Helgi B Schiöth, 2013. "Increased Prefrontal and Parahippocampal Activation with Reduced Dorsolateral Prefrontal and Insular Cortex Activation to Food Images in Obesity: A Meta-Analysis of fMRI Studies," PLOS ONE, Public Library of Science, vol. 8(4), pages 1-9, April.
    9. Kep Kee Loh & Ryota Kanai, 2014. "Higher Media Multi-Tasking Activity Is Associated with Smaller Gray-Matter Density in the Anterior Cingulate Cortex," PLOS ONE, Public Library of Science, vol. 9(9), pages 1-7, September.
    10. Christina Wierenga & Amanda Bischoff-Grethe & A James Melrose & Emily Grenesko-Stevens & Zoë Irvine & Angela Wagner & Alan Simmons & Scott Matthews & Wai-Ying Wendy Yau & Christine Fennema-Notestine &, 2014. "Altered BOLD Response during Inhibitory and Error Processing in Adolescents with Anorexia Nervosa," PLOS ONE, Public Library of Science, vol. 9(3), pages 1-13, March.
    11. Sarah Forberger & Karin Bammann & Jürgen Bauer & Susanne Boll & Gabriele Bolte & Tilman Brand & Andreas Hein & Frauke Koppelin & Sonia Lippke & Jochen Meyer & Claudia R. Pischke & Claudia Voelcker-Reh, 2017. "How to Tackle Key Challenges in the Promotion of Physical Activity among Older Adults (65+): The AEQUIPA Network Approach," IJERPH, MDPI, vol. 14(4), pages 1-18, April.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:21:y:2024:i:3:p:284-:d:1348652. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.