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Maternal Exposure to Potentially Toxic Metals and Birth Weight: Preliminary Results from the DSAN-12M Birth Cohort in the Recôncavo Baiano, Brazil

Author

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  • Homègnon A. Ferréol Bah

    (Institute of Collective Health, Federal University of Bahia, Salvador 40110-040, Brazil
    Laboratory of Toxicology, College of Pharmacy, Federal University of Bahia, Salvador 40170-115, Brazil)

  • Nathália R. dos Santos

    (Laboratory of Toxicology, College of Pharmacy, Federal University of Bahia, Salvador 40170-115, Brazil
    Graduate Program in Pharmacy, College of Pharmacy, Federal University of Bahia, Salvador 40170-115, Brazil)

  • Erival A. Gomes Junior

    (Graduate Program in Food Science, College of Pharmacy, Federal University of Bahia, Salvador 40170-115, Brazil)

  • Daisy O. Costa

    (Laboratory of Toxicology, College of Pharmacy, Federal University of Bahia, Salvador 40170-115, Brazil
    Graduate Program in Pharmacy, College of Pharmacy, Federal University of Bahia, Salvador 40170-115, Brazil)

  • Victor O. Martinez

    (Graduate Program in Pharmacy, College of Pharmacy, Federal University of Bahia, Salvador 40170-115, Brazil)

  • Elis Macêdo Pires

    (Laboratory of Toxicology, College of Pharmacy, Federal University of Bahia, Salvador 40170-115, Brazil)

  • João V. Araújo Santana

    (Laboratory of Toxicology, College of Pharmacy, Federal University of Bahia, Salvador 40170-115, Brazil)

  • Filipe da Silva Cerqueira

    (Laboratory of Toxicology, College of Pharmacy, Federal University of Bahia, Salvador 40170-115, Brazil)

  • José A. Menezes-Filho

    (Institute of Collective Health, Federal University of Bahia, Salvador 40110-040, Brazil
    Laboratory of Toxicology, College of Pharmacy, Federal University of Bahia, Salvador 40170-115, Brazil
    Graduate Program in Pharmacy, College of Pharmacy, Federal University of Bahia, Salvador 40170-115, Brazil)

Abstract

Prenatal exposure to potentially toxic metals (PTM) may impair fetal growth (FG). We investigated the relationship between maternal exposure to lead (Pb), cadmium (Cd) and manganese (Mn) and birth weight (BW) of 74 newborns. Blood was collected during the second trimester of pregnancy to determine Pb (PbB) and Cd (CdB), while hair (MnH) and toenails (MnTn) were used for Mn. Samples were analyzed by graphite furnace atomic absorption spectrophotometry (GFAAS). Sociodemographic and BW data were collected from questionnaires and maternity records, respectively. The medians (P25th–P75th) of PbB, CdB, MnH, and MnTn were, respectively, 0.9 (0.5–1.8) µg/dL; 0.54 (0.1–0.8) µg/L; 0.18 (0.1–0.4) µg/g; and 0.65 (0.37–1.22) µg/g. The means (standard deviation) of birth weight according to sex were 3067 (426.3) and 3442 (431) grams, respectively, for girls and boys. MnTn presented an inverse correlation with the BW/gestational age ratio for girls (rho = −0.478; p = 0.018), suggesting the effect of sex modification. Although BW correlation with CdB was not statistically significant, hierarchical linear regression (beta = −2.08; 95% CI–4.58 to 0.41) suggested a fetotoxic effect. These results confirmed the threat PTMs may represent and the need for more extensive research to elucidate their role in inadequate FG in developing countries.

Suggested Citation

  • Homègnon A. Ferréol Bah & Nathália R. dos Santos & Erival A. Gomes Junior & Daisy O. Costa & Victor O. Martinez & Elis Macêdo Pires & João V. Araújo Santana & Filipe da Silva Cerqueira & José A. Menez, 2023. "Maternal Exposure to Potentially Toxic Metals and Birth Weight: Preliminary Results from the DSAN-12M Birth Cohort in the Recôncavo Baiano, Brazil," IJERPH, MDPI, vol. 20(13), pages 1-15, June.
    • Handle: RePEc:gam:jijerp:v:20:y:2023:i:13:p:6211-:d:1177698
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    References listed on IDEAS

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    1. Kyi Mar Wai & Ohn Mar & Satoko Kosaka & Mitsutoshi Umemura & Chiho Watanabe, 2017. "Prenatal Heavy Metal Exposure and Adverse Birth Outcomes in Myanmar: A Birth-Cohort Study," IJERPH, MDPI, vol. 14(11), pages 1-13, November.
    2. Rasheda Khanam & Ishaan Kumar & Opeyemi Oladapo-Shittu & Claire Twose & ASMD Ashraful Islam & Shyam S. Biswal & Rubhana Raqib & Abdullah H. Baqui, 2021. "Prenatal Environmental Metal Exposure and Preterm Birth: A Scoping Review," IJERPH, MDPI, vol. 18(2), pages 1-18, January.
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