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Prenatal Heavy Metal Exposure and Adverse Birth Outcomes in Myanmar: A Birth-Cohort Study

Author

Listed:
  • Kyi Mar Wai

    (Department of Human Ecology, the University of Tokyo, Tokyo, 113-0033, Japan)

  • Ohn Mar

    (Department of Physiology, University of Medicine 1, Yangon 130404, Myanmar)

  • Satoko Kosaka

    (Department of Human Ecology, the University of Tokyo, Tokyo, 113-0033, Japan)

  • Mitsutoshi Umemura

    (Forestry and Forest Products Research Institute, Forest Research and Management Organization, Tsukuba, Ibaraki 305-8687, Japan)

  • Chiho Watanabe

    (National Institute for Environmental Studies, Tsukuba, Ibaraki 305-8506, Japan)

Abstract

Arsenic, cadmium and lead are well-known environmental contaminants, and their toxicity at low concentration is the target of scientific concern. In this study, we aimed to identify the potential effects of prenatal heavy metal exposure on the birth outcomes among the Myanmar population. This study is part of a birth-cohort study conducted with 419 pregnant women in the Ayeyarwady Division, Myanmar. Face-to-face interviews were performed using a questionnaire, and maternal spot urine samples were collected at the third trimester. Birth outcomes were evaluated at delivery during the follow up. The median values of adjusted urinary arsenic, cadmium, selenium and lead concentration were 74.2, 0.9, 22.6 and 1.8 μg/g creatinine, respectively. Multivariable logistic regression revealed that prenatal cadmium exposure (adjusted odds ratio (OR) = 1.10; 95% confidence interval (CI): 1.01–1.21; p = 0.043), gestational age (adjusted OR = 0.83; 95% CI: 0.72–0.95; p = 0.009) and primigravida mothers (adjusted OR = 4.23; 95% CI: 1.31–13.65; p = 0.016) were the predictors of low birth weight. The present study identified that Myanmar mothers were highly exposed to cadmium. Prenatal maternal cadmium exposure was associated with an occurrence of low birth weight.

Suggested Citation

  • Kyi Mar Wai & Ohn Mar & Satoko Kosaka & Mitsutoshi Umemura & Chiho Watanabe, 2017. "Prenatal Heavy Metal Exposure and Adverse Birth Outcomes in Myanmar: A Birth-Cohort Study," IJERPH, MDPI, vol. 14(11), pages 1-13, November.
    • Handle: RePEc:gam:jijerp:v:14:y:2017:i:11:p:1339-:d:117570
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    Citations

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    Cited by:

    1. Meghan A. Cook & Pardeep S. Jagpal & Khin Hnin Pwint & Lai Lai San & Saint Saint Kyaw Thein & Thidar Pyone & Win Moh Moh Thit & Sally M. Bradberry & Samuel Collins, 2021. "Systematic Review of Human Poisoning and Toxic Exposures in Myanmar," IJERPH, MDPI, vol. 18(7), pages 1-16, March.
    2. Johanna Suomi & Liisa Valsta & Pirkko Tuominen, 2021. "Dietary Heavy Metal Exposure among Finnish Adults in 2007 and in 2012," IJERPH, MDPI, vol. 18(20), pages 1-16, October.
    3. Rasheda Khanam & Ishaan Kumar & Opeyemi Oladapo-Shittu & Claire Twose & ASMD Ashraful Islam & Shyam S. Biswal & Rubhana Raqib & Abdullah H. Baqui, 2021. "Prenatal Environmental Metal Exposure and Preterm Birth: A Scoping Review," IJERPH, MDPI, vol. 18(2), pages 1-18, January.
    4. Maria Dettwiler & Angela C. Flynn & Jessica Rigutto-Farebrother, 2023. "Effects of Non-Essential “Toxic” Trace Elements on Pregnancy Outcomes: A Narrative Overview of Recent Literature Syntheses," IJERPH, MDPI, vol. 20(8), pages 1-16, April.
    5. Nabil al Baraquoni & Samir R. Qouta & Mervi Vänskä & Safwat Y. Diab & Raija-Leena Punamäki & Paola Manduca, 2020. "It Takes Time to Unravel the Ecology of War in Gaza, Palestine: Long-Term Changes in Maternal, Newborn and Toddlers’ Heavy Metal Loads, and Infant and Toddler Developmental Milestones in the Aftermath," IJERPH, MDPI, vol. 17(18), pages 1-18, September.
    6. Homègnon A. Ferréol Bah & Nathália R. dos Santos & Erival A. Gomes Junior & Daisy O. Costa & Victor O. Martinez & Elis Macêdo Pires & João V. Araújo Santana & Filipe da Silva Cerqueira & José A. Menez, 2023. "Maternal Exposure to Potentially Toxic Metals and Birth Weight: Preliminary Results from the DSAN-12M Birth Cohort in the Recôncavo Baiano, Brazil," IJERPH, MDPI, vol. 20(13), pages 1-15, June.
    7. Elisabet Navarro-Tapia & Mariona Serra-Delgado & Lucía Fernández-López & Montserrat Meseguer-Gilabert & María Falcón & Giorgia Sebastiani & Sebastian Sailer & Oscar Garcia-Algar & Vicente Andreu-Ferná, 2021. "Toxic Elements in Traditional Kohl-Based Eye Cosmetics in Spanish and German Markets," IJERPH, MDPI, vol. 18(11), pages 1-16, June.

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