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One-Year Follow-Up of Seroprevalence of SARS-CoV-2 Infection and Anxiety among Health Workers of a French Cancer Center: The PRO-SERO-COV Study

Author

Listed:
  • Brice Richez

    (Department of Anesthesia—Intensive Care, Institut Bergonié, Comprehensive Cancer Center, F-33000 Bordeaux, France
    These authors contributed equally to this work.)

  • Coralie Cantarel

    (Inserm CIC1401, Clinical and Epidemiological Research Unit, Institut Bergonié, Comprehensive Cancer Center, F-33000 Bordeaux, France
    These authors contributed equally to this work.)

  • Françoise Durrieu

    (Department of Biopathology, Institut Bergonié, Comprehensive Cancer Center, F-33000 Bordeaux, France)

  • Isabelle Soubeyran

    (Department of Biopathology, Institut Bergonié, Comprehensive Cancer Center, F-33000 Bordeaux, France)

  • Julie Blanchi

    (Department of Biopathology, Institut Bergonié, Comprehensive Cancer Center, F-33000 Bordeaux, France)

  • Simon Pernot

    (Department of Medical Oncology, Institut Bergonié, Comprehensive Cancer Center, F-33000 Bordeaux, France)

  • Camille Chakiba Brugère

    (Department of Medical Oncology, Institut Bergonié, Comprehensive Cancer Center, F-33000 Bordeaux, France)

  • Guilhem Roubaud

    (Department of Medical Oncology, Institut Bergonié, Comprehensive Cancer Center, F-33000 Bordeaux, France)

  • Sophie Cousin

    (Department of Medical Oncology, Institut Bergonié, Comprehensive Cancer Center, F-33000 Bordeaux, France)

  • Gabriel Etienne

    (Hematology Department, Institut Bergonié, Comprehensive Cancer Center, F-33000 Bordeaux, France)

  • Anne Floquet

    (Department of Medical Oncology, Institut Bergonié, Comprehensive Cancer Center, F-33000 Bordeaux, France)

  • Florence Babre

    (Department of Anesthesia—Intensive Care, Institut Bergonié, Comprehensive Cancer Center, F-33000 Bordeaux, France)

  • Julie Rivalan

    (Department of Anesthesia—Intensive Care, Institut Bergonié, Comprehensive Cancer Center, F-33000 Bordeaux, France)

  • Caroline Lalet

    (Inserm CIC1401, Clinical and Epidemiological Research Unit, Institut Bergonié, Comprehensive Cancer Center, F-33000 Bordeaux, France)

  • Marine Narbonne

    (Department PRISME, Institut Bergonié, Comprehensive Cancer Center, F-33000 Bordeaux, France)

  • Yaniss Belaroussi

    (Inserm CIC1401, Clinical and Epidemiological Research Unit, Institut Bergonié, Comprehensive Cancer Center, F-33000 Bordeaux, France)

  • Carine Bellera

    (Inserm CIC1401, Clinical and Epidemiological Research Unit, Institut Bergonié, Comprehensive Cancer Center, F-33000 Bordeaux, France
    Epicene Team, UMR 1219, Bordeaux Population Health Research Center, University Bordeaux, Inserm, F-33000 Bordeaux, France)

  • Simone Mathoulin-Pélissier

    (Inserm CIC1401, Clinical and Epidemiological Research Unit, Institut Bergonié, Comprehensive Cancer Center, F-33000 Bordeaux, France
    Epicene Team, UMR 1219, Bordeaux Population Health Research Center, University Bordeaux, Inserm, F-33000 Bordeaux, France)

Abstract

Infection of SARS-CoV-2 among health workers (HWs) in contact with cancer patients has been a major issue since the beginning of the pandemic. We aimed to assess the serological immune status of SARS-CoV-2 infection among these HWs. A prospective cohort study was initiated in the comprehensive cancer center of the Nouvelle-Aquitaine region (NA, France). Volunteer HWs working on March 2020 without active infection or symptoms of COVID-19 completed a self-questionnaire and had a blood test at inclusion, at 3 and 12 months. Positive serological status of SARS-CoV-2 infection was defined by anti-nucleocapsid antibodies and/or IgG anti-spike antibodies, except at 12 months due to vaccine. Half of the HWs were included (N = 517) and 89% were followed for three months (N = 500) and one year (N = 462). Seroprevalence of SARS-CoV-2 infection was 3.5% (95% CI: 1.9–5.1), 6.2% (95% CI: 4.1–8.3), and 10% (95% CI: 7.2–12.7) on June–September 2020, September 2020–January 2021, and June–October 2021, respectively. At 12 months, 93.3% had detectable antibodies with 80% vaccinated in the first three months of vaccine availability. The COVID-19-free policy of the institution, respect for barrier gestures, high and early vaccination of HWs, and low prevalence of SARS-CoV-2 in NA may explain the low rate of seropositivity among the HWs of the Institut Bergonié.

Suggested Citation

  • Brice Richez & Coralie Cantarel & Françoise Durrieu & Isabelle Soubeyran & Julie Blanchi & Simon Pernot & Camille Chakiba Brugère & Guilhem Roubaud & Sophie Cousin & Gabriel Etienne & Anne Floquet & F, 2023. "One-Year Follow-Up of Seroprevalence of SARS-CoV-2 Infection and Anxiety among Health Workers of a French Cancer Center: The PRO-SERO-COV Study," IJERPH, MDPI, vol. 20(11), pages 1-14, May.
    • Handle: RePEc:gam:jijerp:v:20:y:2023:i:11:p:5949-:d:1155294
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    References listed on IDEAS

    as
    1. Hafsah Saeed & Ardalan Eslami & Najah T. Nassif & Ann M. Simpson & Sara Lal, 2022. "Anxiety Linked to COVID-19: A Systematic Review Comparing Anxiety Rates in Different Populations," IJERPH, MDPI, vol. 19(4), pages 1-26, February.
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