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Anti-Inflammatory and Anti-Bacterial Potential of Mulberry Leaf Extract on Oral Microorganisms

Author

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  • Dokyeong Kim

    (Precision Medicine Research Center, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea
    Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea)

  • Kyung-Hee Kang

    (Department of Dental Hygiene, Konyang University, Daejeon 35365, Korea)

Abstract

Mulberry leaves extract ( Morus alba extracts; MAE) is known to have therapeutic potentials for numerous human diseases, including diabetes, neurological disorders, cardiovascular diseases, and cancers. However, there has not been sufficient research proving therapeutic effects on oral disease and its related oral risk factors. Thus, we investigated whether MAE has any anti-inflammatory and anti-bacterial effects on risk factors causing oral infectious diseases. To examine the anti-inflammatory response and bacterial inhibition of MAE, we measured intracellular reactive oxygen species (ROS) generation, production of pro-inflammatory cytokines, and the bacterial growth rate. Our study showed that MAE has anti-inflammatory activities, which inhibit the ROS generation and suppressed the production of pro-inflammatory cytokines (TNF-α and IL-6) in human monocyte THP-1 cells by stimulating lipopolysaccharide (LPS) and/or F. nucleatum , which are the virulent factors in periodontal diseases. Furthermore, MAE inhibited the bacterial growth on oral microorganisms ( F. nucleatum and S. mutans ) infected THP-1 cells. These findings suggested that MAE could be a potential natural source for therapeutic drugs in oral infectious disease.

Suggested Citation

  • Dokyeong Kim & Kyung-Hee Kang, 2022. "Anti-Inflammatory and Anti-Bacterial Potential of Mulberry Leaf Extract on Oral Microorganisms," IJERPH, MDPI, vol. 19(9), pages 1-10, April.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:9:p:4984-:d:797607
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    References listed on IDEAS

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    1. Ruslan Medzhitov, 2008. "Origin and physiological roles of inflammation," Nature, Nature, vol. 454(7203), pages 428-435, July.
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