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MicroRNA-21 Expression as a Prognostic Biomarker in Oral Cancer: Systematic Review and Meta-Analysis

Author

Listed:
  • Mario Dioguardi

    (Department of Clinical and Experimental Medicine, University of Foggia, Via Rovelli 50, 71122 Foggia, Italy)

  • Francesca Spirito

    (Department of Clinical and Experimental Medicine, University of Foggia, Via Rovelli 50, 71122 Foggia, Italy)

  • Diego Sovereto

    (Department of Clinical and Experimental Medicine, University of Foggia, Via Rovelli 50, 71122 Foggia, Italy)

  • Mario Alovisi

    (Department of Surgical Sciences, Dental School, University of Turin, 10127 Turin, Italy)

  • Giuseppe Troiano

    (Department of Clinical and Experimental Medicine, University of Foggia, Via Rovelli 50, 71122 Foggia, Italy)

  • Riccardo Aiuto

    (Department of Biomedical, Surgical and Dental Science, University of Milan, 20122 Milan, Italy)

  • Daniele Garcovich

    (Department of Dentistry, Universidad Europea de Valencia, Paseo de la Alameda 7, 46010 Valencia, Spain)

  • Vito Crincoli

    (Department of Basic Medical Sciences, Neurosciences and Sensory Organs, Division of Complex Operating Unit of Dentistry, “Aldo Moro” University of Bari, Piazza G. Cesare 11, 70124 Bari, Italy)

  • Luigi Laino

    (Multidisciplinary Department of Medical-Surgical and Odontostomatological Specialties, University of Campania “Luigi Vanvitelli”, 80121 Naples, Italy)

  • Angela Pia Cazzolla

    (Department of Clinical and Experimental Medicine, University of Foggia, Via Rovelli 50, 71122 Foggia, Italy)

  • Giorgia Apollonia Caloro

    (Unità Operativa Nefrologia e Dialisi, Presidio Ospedaliero Scorrano, ASL (Azienda Sanitaria Locale) Lecce, Via Giuseppina Delli Ponti, 73020 Scorrano, Italy)

  • Michele Di Cosola

    (Department of Clinical and Experimental Medicine, University of Foggia, Via Rovelli 50, 71122 Foggia, Italy)

  • Lorenzo Lo Muzio

    (Department of Clinical and Experimental Medicine, University of Foggia, Via Rovelli 50, 71122 Foggia, Italy)

Abstract

Oral carcinoma represents one of the main carcinomas of the head and neck region, with a 5-year survival rate of less than 50%. Smoking and tobacco use are recognized risk factors. Prognostic survival biomarkers can be a valid tool for assessing a patient’s life expectancy and directing therapy towards specific targets. Among the biomarkers, the alteration of miR-21 expression in tumor tissues is increasingly reported as a valid prognostic biomarker of survival for oral cancer. The purpose of this meta-analysis was, therefore, to investigate and summarize the results in the literature concerning the potential prognostic expression of tissue miR-21 in patients with OSCC. Methods: The systematic review was conducted following the PRISMA guidelines using electronic databases, such as PubMed, Scopus, and the Cochrane Central Register of Controlled Trials, with the use of combinations of keywords, such as miR-21 AND oral cancer, microRNA AND oral cancer, and miR-21. The meta-analysis was performed using the RevMan 5.41 software. Results: At the end of the article-selection process, 10 studies were included in the meta-analysis, and the result for the main outcome was a pooled HR per overall survival (OS) of 1.29 (1.16–1.44) between high and low expression of miR-21. Conclusions: The data in the literature and the results emerging from the systematic review indicate that miR-21 can provide a prognostic indication in oral cancer.

Suggested Citation

  • Mario Dioguardi & Francesca Spirito & Diego Sovereto & Mario Alovisi & Giuseppe Troiano & Riccardo Aiuto & Daniele Garcovich & Vito Crincoli & Luigi Laino & Angela Pia Cazzolla & Giorgia Apollonia Cal, 2022. "MicroRNA-21 Expression as a Prognostic Biomarker in Oral Cancer: Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 19(6), pages 1-12, March.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:6:p:3396-:d:770479
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    References listed on IDEAS

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    1. Richard D Riley & Jill A Hayden & Ewout W Steyerberg & Karel G M Moons & Keith Abrams & Panayiotis A Kyzas & Núria Malats & Andrew Briggs & Sara Schroter & Douglas G Altman & Harry Hemingway & for the, 2013. "Prognosis Research Strategy (PROGRESS) 2: Prognostic Factor Research," PLOS Medicine, Public Library of Science, vol. 10(2), pages 1-9, February.
    2. Ewout W Steyerberg & Karel G M Moons & Danielle A van der Windt & Jill A Hayden & Pablo Perel & Sara Schroter & Richard D Riley & Harry Hemingway & Douglas G Altman & for the PROGRESS Group, 2013. "Prognosis Research Strategy (PROGRESS) 3: Prognostic Model Research," PLOS Medicine, Public Library of Science, vol. 10(2), pages 1-9, February.
    3. Alessandro Liberati & Douglas G Altman & Jennifer Tetzlaff & Cynthia Mulrow & Peter C Gøtzsche & John P A Ioannidis & Mike Clarke & P J Devereaux & Jos Kleijnen & David Moher, 2009. "The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-28, July.
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