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Sleep Deprivation, Immune Suppression and SARS-CoV-2 Infection

Author

Listed:
  • Beatrice Ragnoli

    (Respiratory Unit, S. Andrea Hospital, 13100 Vercelli, Italy)

  • Patrizia Pochetti

    (Respiratory Unit, S. Andrea Hospital, 13100 Vercelli, Italy)

  • Patrizia Pignatti

    (Allergy and Immunology Unit, Istituti Clinici Scientifici Maugeri IRCCS Pavia, 27100 Pavia, Italy)

  • Mariangela Barbieri

    (Respiratory Unit, S. Andrea Hospital, 13100 Vercelli, Italy)

  • Lucrezia Mondini

    (Respiratory Unit, S. Andrea Hospital, 13100 Vercelli, Italy)

  • Luca Ruggero

    (Respiratory Unit, S. Andrea Hospital, 13100 Vercelli, Italy)

  • Liliana Trotta

    (Respiratory Unit, S. Andrea Hospital, 13100 Vercelli, Italy)

  • Paolo Montuschi

    (Pharmacology Department, Faculty of Medicine, Catholic University of the Sacred Heart, 20123 Milan, Italy
    Faculty of Medicine, National Hearth and Lung Institute, Imperial College of Science Technology and Medicine, Airways Disease Section, London SW7 2BX, UK)

  • Mario Malerba

    (Respiratory Unit, S. Andrea Hospital, 13100 Vercelli, Italy
    Department of Traslational Medicine, University of Eastern Piedmont, 28100 Novara, Italy)

Abstract

Sleep health and its adaptation to individual and environmental factors are crucial to promote physical and mental well-being across animal species. In recent years, increasing evidence has been reported regarding the relationship between sleep and the immune system and how sleep disturbances may perturb the delicate balance with severe repercussions on health outcomes. For instance, experimental sleep deprivation studies in vivo have reported several major detrimental effects on immune health, including induced failure of host defense in rats and increased risk for metabolic syndrome (MetS) and immune suppression in humans. In addition, two novel risk factors for dysregulated metabolic physiology have recently been identified: sleep disruption and circadian misalignment. In light of these recent findings about the interplay between sleep and the immune system, in this review, we focus on the relationship between sleep deprivation and immunity against viruses, with a special interest in SARS-CoV-2 infection.

Suggested Citation

  • Beatrice Ragnoli & Patrizia Pochetti & Patrizia Pignatti & Mariangela Barbieri & Lucrezia Mondini & Luca Ruggero & Liliana Trotta & Paolo Montuschi & Mario Malerba, 2022. "Sleep Deprivation, Immune Suppression and SARS-CoV-2 Infection," IJERPH, MDPI, vol. 19(2), pages 1-15, January.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:2:p:904-:d:724657
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    References listed on IDEAS

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    1. J. Allan Hobson, 2005. "Sleep is of the brain, by the brain and for the brain," Nature, Nature, vol. 437(7063), pages 1254-1256, October.
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