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An Evaluation of Exposure to 18 Toxic and/or Essential Trace Elements Exposure in Maternal and Cord Plasma during Pregnancy at Advanced Maternal Age

Author

Listed:
  • Tingfei Gu

    (Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China
    Health Science Center, Peking University, Beijing 100191, China
    These authors contributed equally to this work.)

  • Xiaoqian Jia

    (Institute of Reproductive and Child Health, Peking University, Beijing 100191, China
    Key Laboratory of Reproductive Health, National Health Commission of the People’s Republic of China, Beijing 100191, China
    Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China
    These authors contributed equally to this work.)

  • Huifeng Shi

    (Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China
    National Clinical Research Center for Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China
    National Center for Healthcare Quality Management in Obstetrics, Beijing 100191, China
    These authors contributed equally to this work.)

  • Xiaoli Gong

    (Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China
    National Clinical Research Center for Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China
    National Center for Healthcare Quality Management in Obstetrics, Beijing 100191, China)

  • Jinxi Ma

    (Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China
    Health Science Center, Peking University, Beijing 100191, China)

  • Zhihang Gan

    (Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China
    Health Science Center, Peking University, Beijing 100191, China)

  • Zhixin Yu

    (Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China
    National Clinical Research Center for Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China)

  • Zhiwen Li

    (Institute of Reproductive and Child Health, Peking University, Beijing 100191, China
    Key Laboratory of Reproductive Health, National Health Commission of the People’s Republic of China, Beijing 100191, China
    Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China)

  • Yuan Wei

    (Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China
    National Clinical Research Center for Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China
    National Center for Healthcare Quality Management in Obstetrics, Beijing 100191, China)

Abstract

Pregnant women of advanced maternal age (AMA) are vulnerable to exposure to the surrounding environment. Assessment of trace elements in pregnant women living in specific areas is important for biomonitoring. However, exposure levels and variation patterns during pregnancy remains controversial and attracts extensive public concern. Therefore, we aimed to evaluate exposure of 18 toxic and/or essential trace elements in maternal plasma and in paired cord plasma during pregnancy at AMA. A total of 48 pregnant women of AMA were recruited in Peking University Third Hospital from 2018 to 2021. Eighteen elements found in maternal plasma during the 1st, 2nd, or 3rd trimester of pregnancy and paired cord plasma were measured by 7700x ICP-MS (Agilent Technologies, Palo Alto, CA, USA) and Elan DRC type II ICP-MS (The Perkin-Elmer Corporation, Waltham, MA USA). Concentrations of Pb, Se, Fe, Zn, and Mo all decreased during pregnancy, while Cu increased. Interestingly, concentrations of Rb decreased initially but then increased. Elements as Al, Co, Se, Cu, and Ni showed significantly lower levels in cord than in maternal plasma, while elements as Sr, Fe, Rb, Mn and Zn displayed significantly higher levels in cord than in maternal plasma. Moreover, positively- interacted clusters were found in Ni-Co-Cu-Al-Rb-Zn and Zn-Mn-Al-Pb in maternal blood. Similar positively-interacted clusters were found in Zn-Ni-Co, Zn-Ni-Fe, Mn-Al-Pb, Fe-Pb-Mn, Fe-Ni-Cu, and Rb-Cu-Sb-Fe-Mn in cord plasma. Furthermore, correlations between paired maternal and cord blood samples for As, Sr, and Mo were statistically significant, indicating that the fetus burden may reflect maternal exposure to some extent. Admittedly, levels of toxic and essential elements in our cohort study were comparatively lower than those in the scientific literature.

Suggested Citation

  • Tingfei Gu & Xiaoqian Jia & Huifeng Shi & Xiaoli Gong & Jinxi Ma & Zhihang Gan & Zhixin Yu & Zhiwen Li & Yuan Wei, 2022. "An Evaluation of Exposure to 18 Toxic and/or Essential Trace Elements Exposure in Maternal and Cord Plasma during Pregnancy at Advanced Maternal Age," IJERPH, MDPI, vol. 19(21), pages 1-15, November.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:21:p:14485-:d:963573
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    References listed on IDEAS

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    1. Uchenna Okereafor & Mamookho Makhatha & Lukhanyo Mekuto & Nkemdinma Uche-Okereafor & Tendani Sebola & Vuyo Mavumengwana, 2020. "Toxic Metal Implications on Agricultural Soils, Plants, Animals, Aquatic life and Human Health," IJERPH, MDPI, vol. 17(7), pages 1-24, March.
    2. Yu-Mi Kim & Jin-Young Chung & Hyun Sook An & Sung Yong Park & Byoung-Gwon Kim & Jong Woon Bae & Myoungseok Han & Yeon Jean Cho & Young-Seoub Hong, 2015. "Biomonitoring of Lead, Cadmium, Total Mercury, and Methylmercury Levels in Maternal Blood and in Umbilical Cord Blood at Birth in South Korea," IJERPH, MDPI, vol. 12(10), pages 1-12, October.
    3. Halina B. Röllin & Claudina Nogueira & Bukola Olutola & Kalavati Channa & Jon Ø. Odland, 2018. "Prenatal Exposure to Aluminum and Status of Selected Essential Trace Elements in Rural South African Women at Delivery," IJERPH, MDPI, vol. 15(7), pages 1-16, July.
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