IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v19y2022i18p11242-d908994.html
   My bibliography  Save this article

Endothelial Function Assessment by Flow-Mediated Dilation Method: A Valuable Tool in the Evaluation of the Cardiovascular System

Author

Listed:
  • Szymon Mućka

    (Student Research Group, Department and Clinic of Internal Medicine, Angiology, and Physical Medicine, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Batorego 15 St., 41-902 Bytom, Poland)

  • Martyna Miodońska

    (Student Research Group, Department and Clinic of Internal Medicine, Angiology, and Physical Medicine, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Batorego 15 St., 41-902 Bytom, Poland)

  • Grzegorz K. Jakubiak

    (Department and Clinic of Internal Medicine, Angiology, and Physical Medicine, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Batorego 15 St., 41-902 Bytom, Poland)

  • Monika Starzak

    (Department and Clinic of Internal Medicine, Angiology, and Physical Medicine, Specialistic Hospital No. 2 in Bytom, Batorego 15 St., 41-902 Bytom, Poland)

  • Grzegorz Cieślar

    (Department and Clinic of Internal Medicine, Angiology, and Physical Medicine, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Batorego 15 St., 41-902 Bytom, Poland)

  • Agata Stanek

    (Department and Clinic of Internal Medicine, Angiology, and Physical Medicine, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Batorego 15 St., 41-902 Bytom, Poland)

Abstract

Cardiovascular diseases (CVDs) in the course of atherosclerosis are one of the most critical public health problems in the world. Endothelial cells synthesize numerous biologically active substances involved in regulating the functions of the cardiovascular system. Endothelial dysfunction is an essential element in the pathogenesis of atherosclerosis. Thus, the assessment of endothelial function in people without overt CVD allows for a more accurate estimate of the risk of developing CVD and cardiovascular events. The assessment of endothelial function is primarily used in scientific research, and to a lesser extent in clinical practice. Among the tools for assessing endothelial function, we can distinguish biochemical and physical methods, while physical methods can be divided into invasive and non-invasive methods. Flow-mediated dilation (FMD) is based on the ultrasound assessment of changes in the diameter of the brachial artery as a result of increased blood flow. FMD is a non-invasive, safe, and repeatable test, but it must be performed by qualified and experienced medical staff. The purpose of this paper is to present the literature review results on the assessment of endothelial function using the FMD method, including its methodology, applications in clinical practice and research, limitations, and future perspectives.

Suggested Citation

  • Szymon Mućka & Martyna Miodońska & Grzegorz K. Jakubiak & Monika Starzak & Grzegorz Cieślar & Agata Stanek, 2022. "Endothelial Function Assessment by Flow-Mediated Dilation Method: A Valuable Tool in the Evaluation of the Cardiovascular System," IJERPH, MDPI, vol. 19(18), pages 1-16, September.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:18:p:11242-:d:908994
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/19/18/11242/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/19/18/11242/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Grzegorz K. Jakubiak & Natalia Pawlas & Grzegorz Cieślar & Agata Stanek, 2021. "Pathogenesis and Clinical Significance of In-Stent Restenosis in Patients with Diabetes," IJERPH, MDPI, vol. 18(22), pages 1-23, November.
    2. Grzegorz K. Jakubiak & Natalia Pawlas & Grzegorz Cieślar & Agata Stanek, 2020. "Chronic Lower Extremity Ischemia and Its Association with the Frailty Syndrome in Patients with Diabetes," IJERPH, MDPI, vol. 17(24), pages 1-17, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Vicente Pallarés-Carratalá & Vivencio Barrios & David Fierro-González & Jose Polo-García & Sergio Cinza-Sanjurjo, 2023. "Cardiovascular Risk in Patients with Dyslipidemia and Their Degree of Control as Perceived by Primary Care Physicians in a Survey—TERESA-Opinion Study," IJERPH, MDPI, vol. 20(3), pages 1-11, January.
    2. Alexandru Achim & Agata Stanek & Călin Homorodean & Mihail Spinu & Horea Laurenţiu Onea & Leontin Lazăr & Mădălin Marc & Zoltán Ruzsa & Dan Mircea Olinic, 2022. "Approaches to Peripheral Artery Disease in Diabetes: Are There Any Differences?," IJERPH, MDPI, vol. 19(16), pages 1-11, August.
    3. Marek Zak & Tomasz Sikorski & Magdalena Wasik & Daniel Courteix & Frederic Dutheil & Waldemar Brola, 2022. "Frailty Syndrome—Fall Risk and Rehabilitation Management Aided by Virtual Reality (VR) Technology Solutions: A Narrative Review of the Current Literature," IJERPH, MDPI, vol. 19(5), pages 1-12, March.
    4. Grzegorz K. Jakubiak & Natalia Pawlas & Grzegorz Cieślar & Agata Stanek, 2021. "Pathogenesis and Clinical Significance of In-Stent Restenosis in Patients with Diabetes," IJERPH, MDPI, vol. 18(22), pages 1-23, November.
    5. Kyoung-Hee Cho & Juyeong Kim & Young Choi & Tae-Hyun Kim, 2022. "The Effect of Neighborhood Deprivation on Mortality in Newly Diagnosed Diabetes Patients: A Countrywide Population-Based Korean Retrospective Cohort Study, 2002–2013," IJERPH, MDPI, vol. 19(7), pages 1-14, April.
    6. Carlos Farinha & Hélder Santos & João Serrano & Bárbara Oliveiros & Fernanda M. Silva & Márcio Cascante-Rusenhack & Ana Maria Teixeira & José Pedro Ferreira, 2022. "The Impact of Aquatic Exercise Programs on the Intima-Media thickness of the Carotid Arteries, Hemodynamic Parameters, Lipid Profile and Chemokines of Community-Dwelling Older Persons: A Randomized Co," IJERPH, MDPI, vol. 19(6), pages 1-17, March.
    7. Katarzyna Kaniewska & Anna Kuryliszyn-Moskal & Anna Hryniewicz & Diana Moskal-Jasińska & Mariusz Wojciuk & Zofia Dzięcioł-Anikiej, 2022. "Static Foot Disturbances and the Quality of Life of Older Person with Rheumatoid Arthritis," IJERPH, MDPI, vol. 19(14), pages 1-13, July.
    8. Hsin-Ya Kuo & Chih-Sung Liang & Shih-Jen Tsai & Tzeng-Ji Chen & Che-Sheng Chu & Mu-Hong Chen, 2022. "Dose-Dependent Proton Pump Inhibitor Exposure and Risk of Type 2 Diabetes: A Nationwide Nested Case–Control Study," IJERPH, MDPI, vol. 19(14), pages 1-9, July.
    9. Xunjie Cheng & Tianqi Ma & Feiyun Ouyang & Guogang Zhang & Yongping Bai, 2022. "Trends in the Prevalence of Cardiometabolic Multimorbidity in the United States, 1999–2018," IJERPH, MDPI, vol. 19(8), pages 1-12, April.
    10. Piotr Rola & Jan Jakub Kulczycki & Adrian Włodarczak & Mateusz Barycki & Szymon Włodarczak & Marek Szudrowicz & Łukasz Furtan & Artur Jastrzębski & Maciej Pęcherzewski & Maciej Lesiak & Adrian Doroszk, 2022. "Intravascular Lithotripsy as a Novel Treatment Method for Calcified Unprotected Left Main Diseases—Comparison to Rotational Atherectomy—Short-Term Outcomes," IJERPH, MDPI, vol. 19(15), pages 1-12, July.
    11. Monika Starzak & Agata Stanek & Grzegorz K. Jakubiak & Armand Cholewka & Grzegorz Cieślar, 2022. "Arterial Stiffness Assessment by Pulse Wave Velocity in Patients with Metabolic Syndrome and Its Components: Is It a Useful Tool in Clinical Practice?," IJERPH, MDPI, vol. 19(16), pages 1-14, August.
    12. Chen-Chih Chu & Yong-Chen Chen & Ming-Hsun Lin & Wen-Tung Wu & Feng-Cheng Liu & Hsiang-Cheng Chen & Yu-Ching Chou & Chien-An Sun, 2022. "Association between Clinical Use of Colchicine and Risk of Type 2 Diabetes Mellitus among Gouty Patients: A Nationwide Cohort Study," IJERPH, MDPI, vol. 19(6), pages 1-9, March.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:19:y:2022:i:18:p:11242-:d:908994. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.