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The Utility of Capsicum annuum L. in Internal Medicine and In Dentistry: A Comprehensive Review

Author

Listed:
  • Luciano Maria Catalfamo

    (Department of Biomedical and Dental Sciences, Morphological and Functional Images, University Hospital of Messina, 98100 Messina, Italy
    These authors contributed equally to this work.)

  • Giulia Marrone

    (UOC of Internal Medicine-Center of Hypertension and Nephrology Unit, Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy
    These authors contributed equally to this work.)

  • Michele Basilicata

    (UOSD Special Care Dentistry, Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, 00100 Rome, Italy
    These authors contributed equally to this work.)

  • Ilaria Vivarini

    (UOC of Internal Medicine-Center of Hypertension and Nephrology Unit, Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy)

  • Vincenza Paolino

    (UOSD Special Care Dentistry, Department of Systems Medicine, University of Rome Tor Vergata, 00100 Rome, Italy)

  • David Della-Morte

    (Department of Systems Medicine, University of Rome “Tor Vergata”, 00133 Rome, Italy
    Department of Human Sciences and Quality of Life Promotion, San Raffaele University, 00166 Rome, Italy
    Department of Neurology, Evelyn F. McKnight Brain Institute, Miller School of Medicine, University of Miami, Miami, FL 33136, USA)

  • Francesco Saverio De Ponte

    (Department of Biomedical and Dental Sciences, Morphological and Functional Images, University Hospital of Messina, 98100 Messina, Italy)

  • Francesca Di Daniele

    (School of Applied Medical, Surgical Sciences, University of Rome Tor Vergata, 00133 Rome, Italy
    UOSD of Dermatology, Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy)

  • Domenico Quattrone

    (Department of Biomedical and Dental Sciences, Morphological and Functional Images, University Hospital of Messina, 98100 Messina, Italy)

  • Danilo De Rinaldis

    (Department of Biomedical and Dental Sciences, Morphological and Functional Images, University Hospital of Messina, 98100 Messina, Italy)

  • Patrizio Bollero

    (UOSD Special Care Dentistry, Department of Systems Medicine, University of Rome Tor Vergata, 00100 Rome, Italy)

  • Nicola Di Daniele

    (UOC of Internal Medicine-Center of Hypertension and Nephrology Unit, Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy)

  • Annalisa Noce

    (UOC of Internal Medicine-Center of Hypertension and Nephrology Unit, Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy)

Abstract

Capsaicin is a chili peppers extract, genus Capsicum, commonly used as a food spice. Since ancient times, Capsaicin has been used as a “homeopathic remedy” for treating a wild range of pathological conditions but without any scientific knowledge about its action. Several studies have demonstrated its potentiality in cardiovascular, nephrological, nutritional, and other medical fields. Capsaicin exerts its actions thanks to the bond with transient receptor potential vanilloid subtype 1 (TRPV1). TRPV1 is a nociceptive receptor, and its activation starts with a neurosensitive impulse, responsible for a burning pain sensation. However, constant local application of Capsaicin desensitized neuronal cells and leads to relief from neuropathic pain. In this review, we analyze the potential adjuvant role of Capsaicin in the treatment of different pathological conditions either in internal medicine or dentistry. Moreover, we present our experience in five patients affected by oro-facial pain consequent to post-traumatic trigeminal neuropathy, not responsive to any remedy, and successfully treated with topical application of Capsaicin. The topical application of Capsaicin is safe, effective, and quite tolerated by patients. For these reasons, in addition to the already-proven beneficial actions in the internal field, it represents a promising method for the treatment of neuropathic oral diseases.

Suggested Citation

  • Luciano Maria Catalfamo & Giulia Marrone & Michele Basilicata & Ilaria Vivarini & Vincenza Paolino & David Della-Morte & Francesco Saverio De Ponte & Francesca Di Daniele & Domenico Quattrone & Danilo, 2022. "The Utility of Capsicum annuum L. in Internal Medicine and In Dentistry: A Comprehensive Review," IJERPH, MDPI, vol. 19(18), pages 1-20, September.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:18:p:11187-:d:908064
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    References listed on IDEAS

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    1. Michael J. Caterina & Mark A. Schumacher & Makoto Tominaga & Tobias A. Rosen & Jon D. Levine & David Julius, 1997. "The capsaicin receptor: a heat-activated ion channel in the pain pathway," Nature, Nature, vol. 389(6653), pages 816-824, October.
    2. David E. Clapham, 2003. "TRP channels as cellular sensors," Nature, Nature, vol. 426(6966), pages 517-524, December.
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