IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v19y2022i15p9477-d878346.html
   My bibliography  Save this article

Prenatal Effects of Nicotine on Obesity Risks: A Narrative Review

Author

Listed:
  • Olivia White

    (Behavioral Neuropharmacology and Neuroimaging Laboratory on Addictions (BNNLA), Clinical Research Institute on Addictions, Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14203, USA
    Department of Psychology, University at Buffalo, Buffalo, NY 14203, USA)

  • Nicole Roeder

    (Behavioral Neuropharmacology and Neuroimaging Laboratory on Addictions (BNNLA), Clinical Research Institute on Addictions, Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14203, USA
    Department of Psychology, University at Buffalo, Buffalo, NY 14203, USA)

  • Kenneth Blum

    (Division of Addiction Research, Center for Psychiatry, Medicine & Primary Care (Office of Provost), Western University Health Sciences, Pomona, CA 91766, USA)

  • Rina D. Eiden

    (Department of Psychology, Social Science Research Institute, The Pennsylvania State University, University Park, PA 16801, USA)

  • Panayotis K. Thanos

    (Behavioral Neuropharmacology and Neuroimaging Laboratory on Addictions (BNNLA), Clinical Research Institute on Addictions, Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14203, USA
    Department of Psychology, University at Buffalo, Buffalo, NY 14203, USA)

Abstract

Nicotine usage by mothers throughout pregnancy has been observed to relate to numerous deleterious effects in children, especially relating to obesity. Children who have prenatally been exposed to nicotine tend to have lower birth weights, with an elevated risk of becoming overweight throughout development and into their adolescent and adult life. There are numerous theories as to how this occurs: catch-up growth theory, thrifty phenotype theory, neurotransmitter or endocrine imbalances theory, and a more recent examination on the genetic factors relating to obesity risk. In addition to the negative effect on bodyweight and BMI, individuals with obesity may also suffer from numerous comorbidities involving metabolic disease. These may include type 1 and 2 diabetes, high cholesterol levels, and liver disease. Predisposition for obesity with nicotine usage may also be associated with genetic risk alleles for obesity, such as the DRD2 A1 variant. This is important for prenatally nicotine-exposed individuals as an opportunity to provide early prevention and intervention of obesity-related risks.

Suggested Citation

  • Olivia White & Nicole Roeder & Kenneth Blum & Rina D. Eiden & Panayotis K. Thanos, 2022. "Prenatal Effects of Nicotine on Obesity Risks: A Narrative Review," IJERPH, MDPI, vol. 19(15), pages 1-29, August.
  • Handle: RePEc:gam:jijerp:v:19:y:2022:i:15:p:9477-:d:878346
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/19/15/9477/pdf
    Download Restriction: no

    File URL: https://www.mdpi.com/1660-4601/19/15/9477/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Gilberto Gerra & Elisa Benedetti & Giuliano Resce & Roberta Potente & Arianna Cutilli & Sabrina Molinaro, 2020. "Socioeconomic Status, Parental Education, School Connectedness and Individual Socio-Cultural Resources in Vulnerability for Drug Use among Students," IJERPH, MDPI, vol. 17(4), pages 1-17, February.
    2. Thorgeir E. Thorgeirsson & Frank Geller & Patrick Sulem & Thorunn Rafnar & Anna Wiste & Kristinn P. Magnusson & Andrei Manolescu & Gudmar Thorleifsson & Hreinn Stefansson & Andres Ingason & Simon N. S, 2008. "A variant associated with nicotine dependence, lung cancer and peripheral arterial disease," Nature, Nature, vol. 452(7187), pages 638-642, April.
    3. Kenneth Blum & Margaret A Madigan & Lyle Fried & Eric R Braverman & John Giordano & Rajendra D Badgaiyan, 2017. "Coupling Genetic Addiction Risk Score (GARS) and Pro Dopamine Regulation (KB220) to Combat Substance Use Disorder (SUD)," Global Journal of Addiction & Rehabilitation Medicine, Juniper Publishers Inc., vol. 1(2), pages 26-33, February.
    4. Kenneth Blum & Mark S. Gold & Luis Llanos-Gomez & Rehan Jalali & Panayotis K. Thanos & Abdalla Bowirrat & William B. Downs & Debasis Bagchi & Eric R. Braverman & David Baron & Alphonso Kenison Roy & R, 2021. "Hypothesizing Nutrigenomic-Based Precision Anti-Obesity Treatment and Prophylaxis: Should We Be Targeting Sarcopenia Induced Brain Dysfunction?," IJERPH, MDPI, vol. 18(18), pages 1-18, September.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Cristina Lázaro-Pérez & José Ángel Martínez-López & José Gómez-Galán, 2020. "Addictions in Spanish College Students in Confinement Times: Preventive and Social Perspective," Social Sciences, MDPI, vol. 9(11), pages 1-21, October.
    2. Junaidi Budi Prihanto & Faridha Nurhayati & Endang Sri Wahjuni & Ryota Matsuyama & Miwako Tsunematsu & Masayuki Kakehashi, 2021. "Health Literacy and Health Behavior: Associated Factors in Surabaya High School Students, Indonesia," IJERPH, MDPI, vol. 18(15), pages 1-20, July.
    3. Carsten Müller & Kareem El-Ansari & Walid El Ansari, 2022. "Health-Promoting Behavior and Lifestyle Characteristics of Students as a Function of Sex and Academic Level," IJERPH, MDPI, vol. 19(12), pages 1-18, June.
    4. Li-Shiun Chen & Ping Wang & Yao Yao, 2017. "Smoking, Health Capital, and Longevity: Evaluation of Personalized Cessation Treatments in a Lifecycle Model with Heterogeneous Agents," NBER Working Papers 23820, National Bureau of Economic Research, Inc.
    5. Jonsdottir, Gudrun A. & Einarsson, Gudmundur & Thorleifsson, Gudmar & Magnusson, Sigurdur H. & Gunnarsson, Arni F. & Frigge, Michael L. & Gisladottir, Rosa S. & Unnsteinsdottir, Unnur & Gunnarsson, Bj, 2021. "Genetic propensities for verbal and spatial ability have opposite effects on body mass index and risk of schizophrenia," Intelligence, Elsevier, vol. 88(C).
    6. Krzysztof Chmielowiec & Jolanta Chmielowiec & Aleksandra Strońska-Pluta & Grzegorz Trybek & Małgorzata Śmiarowska & Aleksandra Suchanecka & Grzegorz Woźniak & Aleksandra Jaroń & Anna Grzywacz, 2022. "Association of Polymorphism CHRNA5 and CHRNA3 Gene in People Addicted to Nicotine," IJERPH, MDPI, vol. 19(17), pages 1-12, August.
    7. Margaret A. Madigan & Ashim Gupta & Abdalla Bowirrat & David Baron & Rajendra D. Badgaiyan & Igor Elman & Catherine A. Dennen & Eric R. Braverman & Mark S. Gold & Kenneth Blum, 2022. "Precision Behavioral Management (PBM) and Cognitive Control as a Potential Therapeutic and Prophylactic Modality for Reward Deficiency Syndrome (RDS): Is There Enough Evidence?," IJERPH, MDPI, vol. 19(11), pages 1-15, May.
    8. Shahida Anusha Siddiqui & Prachi Singh & Sipper Khan & Ito Fernando & Igor Spartakovich Baklanov & Tigran Garrievich Ambartsumov & Salam A. Ibrahim, 2022. "Cultural, Social and Psychological Factors of the Conservative Consumer towards Legal Cannabis Use—A Review since 2013," Sustainability, MDPI, vol. 14(17), pages 1-22, September.
    9. Orit Shapiro & Riki Tesler & Sharon Barak & Lilach Ben-Meir & Ariela Giladi & Rachel Nissanholtz-Gannot & Gizell Green & Moti Zwilling & Avi Zigdon & Yossi Harel-Fisch, 2022. "A Biopsychosocial Approach to Examining Alcohol Consumption among Youth during the COVID-19 Pandemic," Sustainability, MDPI, vol. 14(22), pages 1-15, November.
    10. Hilda García-Pérez & Stephen S. Kulis & Flavio F. Marsiglia & Paul A. Estabrooks, 2023. "Urban Violence, Migration and Alcohol, Tobacco, and Marijuana Use among Transnational Students in Northern Mexico," IJERPH, MDPI, vol. 21(1), pages 1-14, December.
    11. Snaedis Kristmundsdottir & Hakon Jonsson & Marteinn T. Hardarson & Gunnar Palsson & Doruk Beyter & Hannes P. Eggertsson & Arnaldur Gylfason & Gardar Sveinbjornsson & Guillaume Holley & Olafur A. Stefa, 2023. "Sequence variants affecting the genome-wide rate of germline microsatellite mutations," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    12. Bierut, Laura & Biroli, Pietro & Galama, Titus J. & Thom, Kevin, 2023. "Challenges in studying the interplay of genes and environment. A study of childhood financial distress moderating genetic predisposition for peak smoking," Journal of Economic Psychology, Elsevier, vol. 98(C).
    13. Elisa Benedetti & Giuliano Resce & Paolo Brunori & Sabrina Molinaro, 2021. "Cannabis Policy Changes and Adolescent Cannabis Use: Evidence from Europe," IJERPH, MDPI, vol. 18(10), pages 1-16, May.
    14. Dorota Kleszczewska & Joanna Mazur & Katarzyna Porwit & Anna Kowalewska, 2022. "Who Is Able to Resist What Is Forbidden?—The Relationship between Health Literacy and Risk Behaviours in Secondary School Students in the Broader Social and Educational Context," IJERPH, MDPI, vol. 19(15), pages 1-16, July.
    15. Xiao-Ying Wu & Shan-Yu Zhou & Zhong-Zheng Niu & Tao Liu & Chuan-Bo Xie & Wei-Qing Chen, 2015. "CHRNA3 rs6495308 Genotype as an Effect Modifier of the Association between Daily Cigarette Consumption and Hypertension in Chinese Male Smokers," IJERPH, MDPI, vol. 12(4), pages 1-14, April.
    16. Taylor, Amy E. & Davies, Neil M. & Ware, Jennifer J. & VanderWeele, Tyler & Smith, George Davey & Munafò, Marcus R., 2014. "Mendelian randomization in health research: Using appropriate genetic variants and avoiding biased estimates," Economics & Human Biology, Elsevier, vol. 13(C), pages 99-106.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:19:y:2022:i:15:p:9477-:d:878346. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.