IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v452y2008i7187d10.1038_nature06846.html
   My bibliography  Save this article

A variant associated with nicotine dependence, lung cancer and peripheral arterial disease

Author

Listed:
  • Thorgeir E. Thorgeirsson

    (deCODE Genetics)

  • Frank Geller

    (deCODE Genetics)

  • Patrick Sulem

    (deCODE Genetics)

  • Thorunn Rafnar

    (deCODE Genetics)

  • Anna Wiste

    (deCODE Genetics
    Emory University, Atlanta, GA 30322, USA)

  • Kristinn P. Magnusson

    (deCODE Genetics)

  • Andrei Manolescu

    (deCODE Genetics)

  • Gudmar Thorleifsson

    (deCODE Genetics)

  • Hreinn Stefansson

    (deCODE Genetics)

  • Andres Ingason

    (deCODE Genetics)

  • Simon N. Stacey

    (deCODE Genetics)

  • Jon T. Bergthorsson

    (deCODE Genetics)

  • Steinunn Thorlacius

    (deCODE Genetics)

  • Julius Gudmundsson

    (deCODE Genetics)

  • Thorlakur Jonsson

    (deCODE Genetics)

  • Margret Jakobsdottir

    (deCODE Genetics)

  • Jona Saemundsdottir

    (deCODE Genetics)

  • Olof Olafsdottir

    (deCODE Genetics)

  • Larus J. Gudmundsson

    (deCODE Genetics)

  • Gyda Bjornsdottir

    (deCODE Genetics)

  • Kristleifur Kristjansson

    (deCODE Genetics)

  • Halla Skuladottir

    (Department of Medical Oncology,)

  • Helgi J. Isaksson

    (Department of Pathology,)

  • Tomas Gudbjartsson

    (Department of Cardiothoracic Surgery,)

  • Gregory T. Jones

    (Dunedin School of Medicine, University of Otago)

  • Thomas Mueller

    (Konventhospital Barmherzige Brueder, 4020 Linz, Austria)

  • Anders Gottsäter

    (Center for Vascular Diseases, University Hospital, MAS, 205 02 Malmö, Sweden)

  • Andrea Flex

    (Laboratory of Vascular Biology and Genetics, A. Gemelli University Hospital, Universita Cattolica del Sacro Cuore School of Medicine)

  • Katja K. H. Aben

    (Radboud University Nijmegen Medical Centre
    Comprehensive Cancer Center East)

  • Femmie de Vegt

    (Radboud University Nijmegen Medical Centre)

  • Peter F. A. Mulders

    (Radboud University Nijmegen Medical Centre)

  • Dolores Isla

    (University Hospital)

  • Maria J. Vidal

    (University Hospital)

  • Laura Asin

    (Nanotechnology Institute of Aragon)

  • Berta Saez

    (Health Science Institute)

  • Laura Murillo

    (Hospital Reina Sofia)

  • Thorsteinn Blondal

    (Primary Health Care Centre, 101 Reykjavik, Iceland)

  • Halldor Kolbeinsson

    (and)

  • Jon G. Stefansson

    (and)

  • Ingunn Hansdottir

    (Vogur SAA Addiction Treatment Center)

  • Valgerdur Runarsdottir

    (Vogur SAA Addiction Treatment Center)

  • Roberto Pola

    (Laboratory of Vascular Biology and Genetics, A. Gemelli University Hospital, Universita Cattolica del Sacro Cuore School of Medicine
    OASI Institute for Research and Care (IRCCS))

  • Bengt Lindblad

    (Center for Vascular Diseases, University Hospital, MAS, 205 02 Malmö, Sweden)

  • Andre M. van Rij

    (Dunedin School of Medicine, University of Otago)

  • Benjamin Dieplinger

    (Konventhospital Barmherzige Brueder, 4020 Linz, Austria)

  • Meinhard Haltmayer

    (Konventhospital Barmherzige Brueder, 4020 Linz, Austria)

  • Jose I. Mayordomo

    (University Hospital
    Nanotechnology Institute of Aragon
    Health Science Institute)

  • Lambertus A. Kiemeney

    (Radboud University Nijmegen Medical Centre
    Comprehensive Cancer Center East
    Radboud University Nijmegen Medical Centre)

  • Stefan E. Matthiasson

    (School of Medicine, University of Iceland)

  • Hogni Oskarsson

    (Therapeia)

  • Thorarinn Tyrfingsson

    (Vogur SAA Addiction Treatment Center)

  • Daniel F. Gudbjartsson

    (deCODE Genetics)

  • Jeffrey R. Gulcher

    (deCODE Genetics)

  • Steinn Jonsson

    (Landspitali University Hospital, 101 Reykjavik, Iceland)

  • Unnur Thorsteinsdottir

    (deCODE Genetics
    School of Medicine, University of Iceland)

  • Augustine Kong

    (deCODE Genetics)

  • Kari Stefansson

    (deCODE Genetics
    School of Medicine, University of Iceland)

Abstract

Where there's smoke... With the advent of large genomic data sets, geneticists can examine at a new level the influence of genes on behaviour. Two groups have conducted genome-wide association studies involving lung cancer, and both find that sequences in the nicotinic acetylcholine receptor subunit gene cluster contribute susceptibility, although the groups took different paths to this result. Hung et al. suggest that this susceptibility is not related to smoking status or frequency, and show association with a specific amino acid change. Thorgeirsson et al. find that alleles present in a cluster of nicotinic acid receptor genes do not influence whether or not a person smokes, but do affect the number of cigarettes smoked per day, and are therefore also associated with risk of lung cancer and peripheral arterial disease. Either way, the possible potential of nicotinic acetylcholine receptors as drug targets is underlined.

Suggested Citation

  • Thorgeir E. Thorgeirsson & Frank Geller & Patrick Sulem & Thorunn Rafnar & Anna Wiste & Kristinn P. Magnusson & Andrei Manolescu & Gudmar Thorleifsson & Hreinn Stefansson & Andres Ingason & Simon N. S, 2008. "A variant associated with nicotine dependence, lung cancer and peripheral arterial disease," Nature, Nature, vol. 452(7187), pages 638-642, April.
    • Handle: RePEc:nat:nature:v:452:y:2008:i:7187:d:10.1038_nature06846
    DOI: 10.1038/nature06846
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature06846
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature06846?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Krzysztof Chmielowiec & Jolanta Chmielowiec & Aleksandra Strońska-Pluta & Grzegorz Trybek & Małgorzata Śmiarowska & Aleksandra Suchanecka & Grzegorz Woźniak & Aleksandra Jaroń & Anna Grzywacz, 2022. "Association of Polymorphism CHRNA5 and CHRNA3 Gene in People Addicted to Nicotine," IJERPH, MDPI, vol. 19(17), pages 1-12, August.
    2. Robert B Weiss & Timothy B Baker & Dale S Cannon & Andrew von Niederhausern & Diane M Dunn & Nori Matsunami & Nanda A Singh & Lisa Baird & Hilary Coon & William M McMahon & Megan E Piper & Michael C F, 2008. "A Candidate Gene Approach Identifies the CHRNA5-A3-B4 Region as a Risk Factor for Age-Dependent Nicotine Addiction," PLOS Genetics, Public Library of Science, vol. 4(7), pages 1-11, July.
    3. Xiao-Ying Wu & Shan-Yu Zhou & Zhong-Zheng Niu & Tao Liu & Chuan-Bo Xie & Wei-Qing Chen, 2015. "CHRNA3 rs6495308 Genotype as an Effect Modifier of the Association between Daily Cigarette Consumption and Hypertension in Chinese Male Smokers," IJERPH, MDPI, vol. 12(4), pages 1-14, April.
    4. Li-Shiun Chen & Ping Wang & Yao Yao, 2017. "Smoking, Health Capital, and Longevity: Evaluation of Personalized Cessation Treatments in a Lifecycle Model with Heterogeneous Agents," NBER Working Papers 23820, National Bureau of Economic Research, Inc.
    5. Katherine S Elliott & Eleftheria Zeggini & Mark I McCarthy & Julius Gudmundsson & Patrick Sulem & Simon N Stacey & Steinunn Thorlacius & Laufey Amundadottir & Henrik Grönberg & Jianfeng Xu & Valerie G, 2010. "Evaluation of Association of HNF1B Variants with Diverse Cancers: Collaborative Analysis of Data from 19 Genome-Wide Association Studies," PLOS ONE, Public Library of Science, vol. 5(5), pages 1-8, May.
    6. Olivia White & Nicole Roeder & Kenneth Blum & Rina D. Eiden & Panayotis K. Thanos, 2022. "Prenatal Effects of Nicotine on Obesity Risks: A Narrative Review," IJERPH, MDPI, vol. 19(15), pages 1-29, August.
    7. Snaedis Kristmundsdottir & Hakon Jonsson & Marteinn T. Hardarson & Gunnar Palsson & Doruk Beyter & Hannes P. Eggertsson & Arnaldur Gylfason & Gardar Sveinbjornsson & Guillaume Holley & Olafur A. Stefa, 2023. "Sequence variants affecting the genome-wide rate of germline microsatellite mutations," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    8. Guo-Bo Chen & Yi Xu & Hai-Ming Xu & Ming D Li & Jun Zhu & Xiang-Yang Lou, 2011. "Practical and Theoretical Considerations in Study Design for Detecting Gene-Gene Interactions Using MDR and GMDR Approaches," PLOS ONE, Public Library of Science, vol. 6(2), pages 1-9, February.
    9. Bierut, Laura & Biroli, Pietro & Galama, Titus J. & Thom, Kevin, 2023. "Challenges in studying the interplay of genes and environment. A study of childhood financial distress moderating genetic predisposition for peak smoking," Journal of Economic Psychology, Elsevier, vol. 98(C).
    10. Jonsdottir, Gudrun A. & Einarsson, Gudmundur & Thorleifsson, Gudmar & Magnusson, Sigurdur H. & Gunnarsson, Arni F. & Frigge, Michael L. & Gisladottir, Rosa S. & Unnsteinsdottir, Unnur & Gunnarsson, Bj, 2021. "Genetic propensities for verbal and spatial ability have opposite effects on body mass index and risk of schizophrenia," Intelligence, Elsevier, vol. 88(C).
    11. Taylor, Amy E. & Davies, Neil M. & Ware, Jennifer J. & VanderWeele, Tyler & Smith, George Davey & Munafò, Marcus R., 2014. "Mendelian randomization in health research: Using appropriate genetic variants and avoiding biased estimates," Economics & Human Biology, Elsevier, vol. 13(C), pages 99-106.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:452:y:2008:i:7187:d:10.1038_nature06846. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.