IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v18y2021i2p667-d480345.html
   My bibliography  Save this article

Exploring the Association of Autism Spectrum Disorders and Constipation through Analysis of the Gut Microbiome

Author

Listed:
  • Shih-Chen Fu

    (Institute of Statistics, National Chiao Tung University, Hsinchu 30010, Taiwan)

  • Chung-Han Lee

    (Institute of Statistics, National Chiao Tung University, Hsinchu 30010, Taiwan)

  • Hsiuying Wang

    (Institute of Statistics, National Chiao Tung University, Hsinchu 30010, Taiwan)

Abstract

Over the past two decades, research into the role of the gut microbiome in regulating the central nervous system has rapidly increased. Several neurodevelopmental diseases have been linked to the unbalance of gut microbiota, including autism. Children on the autism spectrum often suffer from gastrointestinal symptoms, including constipation, which is four times more prevalent than it is in children without autism spectrum disorders (ASD). Although studies in animals have shown the crucial role of the microbiota in key aspects of neurodevelopment, there is currently no consensus on how the alteration of microbial composition affects the pathogenesis of ASD, let alone how it exerts an impact on the following comorbidities. In our study, we were able to control the effects of constipation on gut dysbiosis and distinguish neuropathological-related and gastrointestinal-related bacteria in ASD patients separately. By analyzing published data, eight additional bacteria significantly altered in autistic individuals were identified in our study. All of them had a decreased relative abundance in ASD patients, except Lactobacillaceae and Peptostreptococcaceae. Eighteen and eleven bacteria were significantly correlated with ASD symptoms and constipation, respectively. Among those, six bacteria were overlapped between the groups. We have found another six bacteria highly associated with constipation status in ASD patients only. By conducting Welch’s t-test, we were able to demonstrate the critical roles of microbes in ASD core and gastrointestinal symptoms and raised the hypotheses of their confounding and mediating effects on the relationship between the two symptoms.

Suggested Citation

  • Shih-Chen Fu & Chung-Han Lee & Hsiuying Wang, 2021. "Exploring the Association of Autism Spectrum Disorders and Constipation through Analysis of the Gut Microbiome," IJERPH, MDPI, vol. 18(2), pages 1-13, January.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:2:p:667-:d:480345
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/18/2/667/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/18/2/667/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Ruth E. Ley & Peter J. Turnbaugh & Samuel Klein & Jeffrey I. Gordon, 2006. "Human gut microbes associated with obesity," Nature, Nature, vol. 444(7122), pages 1022-1023, December.
    2. Maria De Angelis & Maria Piccolo & Lucia Vannini & Sonya Siragusa & Andrea De Giacomo & Diana Isabella Serrazzanetti & Fernanda Cristofori & Maria Elisabetta Guerzoni & Marco Gobbetti & Ruggiero Franc, 2013. "Fecal Microbiota and Metabolome of Children with Autism and Pervasive Developmental Disorder Not Otherwise Specified," PLOS ONE, Public Library of Science, vol. 8(10), pages 1-1, October.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Mercedes Y. Lacourt-Ventura & Brayan Vilanova-Cuevas & Delmarie Rivera-Rodríguez & Raysa Rosario-Acevedo & Christine Miranda & Gerónimo Maldonado-Martínez & Johanna Maysonet & Darlene Vargas & Yelitza, 2021. "Soy and Frequent Dairy Consumption with Subsequent Equol Production Reveals Decreased Gut Health in a Cohort of Healthy Puerto Rican Women," IJERPH, MDPI, vol. 18(16), pages 1-17, August.
    2. Rongrong Yu & Muchen Zhang & Temoor Ahmed & Zhifeng Wu & Luqiong Lv & Guoling Zhou & Bin Li, 2022. "Metabolic and Proteomic Profiles Reveal the Response of the ASD-Associated Resistant Strain 6-1 of Lactobacillus plantarum to Propionic Acid," IJERPH, MDPI, vol. 19(24), pages 1-15, December.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Qian Zhang & Lijuan Zhang & Yang Lyu & Yutao Shi & Liangyun Zhu & Min Zhang & Yuyan Zhao & Di Zhao & Lei Wang & Dan Yi & Yongqing Hou & Tao Wu, 2022. "Dietary supplementation of Lactobacillus zeae regulated the gut microbiome in piglets infected with enterotoxigenic Escherichia coli," Czech Journal of Animal Science, Czech Academy of Agricultural Sciences, vol. 67(1), pages 27-38.
    2. Kiran Konain & Sadia & Turfa Nadeem & Adeed Khan & Warda Iqbal & Arsalan & Amir Javed & Ruby Khan & Kainat Jamil & Kainat Jamil, 2018. "Importance of Probiotics in Gastrointestinal Tract," Journal of Asian Scientific Research, Asian Economic and Social Society, vol. 8(3), pages 128-143, March.
    3. Pirjo Wacklin & Harri Mäkivuokko & Noora Alakulppi & Janne Nikkilä & Heli Tenkanen & Jarkko Räbinä & Jukka Partanen & Kari Aranko & Jaana Mättö, 2011. "Secretor Genotype (FUT2 gene) Is Strongly Associated with the Composition of Bifidobacteria in the Human Intestine," PLOS ONE, Public Library of Science, vol. 6(5), pages 1-10, May.
    4. Frisha Abkar & Sajjad ur Rahman & Ahsan Naveed & Hira Rasheed & Syed Ashar Mehfooz, 2019. "Evaluation of Oral Microflora in Obese and Non- Obese Humans from District Faisalabad, Pakistan," Current Research in Diabetes & Obesity Journal, Juniper Publishers Inc., vol. 10(1), pages 12-16, March.
    5. Mariana F. Fernández & Iris Reina-Pérez & Juan Manuel Astorga & Andrea Rodríguez-Carrillo & Julio Plaza-Díaz & Luis Fontana, 2018. "Breast Cancer and Its Relationship with the Microbiota," IJERPH, MDPI, vol. 15(8), pages 1-20, August.
    6. Frederick A Matsen IV & Steven N Evans, 2013. "Edge Principal Components and Squash Clustering: Using the Special Structure of Phylogenetic Placement Data for Sample Comparison," PLOS ONE, Public Library of Science, vol. 8(3), pages 1-15, March.
    7. Vinod Nikhra, 2019. "The Novel Dimensions of Cardio-Metabolic Health Gut Microbiota, Dysbiosis and its Fallouts," Current Research in Diabetes & Obesity Journal, Juniper Publishers Inc., vol. 11(1), pages 28-37, June.
    8. Maja Czerwińska-Rogowska & Karolina Skonieczna-Żydecka & Krzysztof Kaseja & Karolina Jakubczyk & Joanna Palma & Marta Bott-Olejnik & Sławomir Brzozowski & Ewa Stachowska, 2022. "Kitchen Diet vs. Industrial Diets—Impact on Intestinal Barrier Parameters among Stroke Patients," IJERPH, MDPI, vol. 19(10), pages 1-11, May.
    9. Zemin Zheng & Jinchi Lv & Wei Lin, 2021. "Nonsparse Learning with Latent Variables," Operations Research, INFORMS, vol. 69(1), pages 346-359, January.
    10. Elio L Herzog & Melania Wäfler & Irene Keller & Sebastian Wolf & Martin S Zinkernagel & Denise C Zysset-Burri, 2021. "The importance of age in compositional and functional profiling of the human intestinal microbiome," PLOS ONE, Public Library of Science, vol. 16(10), pages 1-13, October.
    11. Michael DiMarzio & Brigida Rusconi & Neela H Yennawar & Mark Eppinger & Andrew D Patterson & Edward G Dudley, 2017. "Identification of a mouse Lactobacillus johnsonii strain with deconjugase activity against the FXR antagonist T-β-MCA," PLOS ONE, Public Library of Science, vol. 12(9), pages 1-15, September.
    12. Tamar Ringel-Kulka & Jing Cheng & Yehuda Ringel & Jarkko Salojärvi & Ian Carroll & Airi Palva & Willem M de Vos & Reetta Satokari, 2013. "Intestinal Microbiota in Healthy U.S. Young Children and Adults—A High Throughput Microarray Analysis," PLOS ONE, Public Library of Science, vol. 8(5), pages 1-10, May.
    13. Ming Yang & Xiaoqiang Qi & Nan Li & Jussuf T. Kaifi & Shiyou Chen & Andrew A. Wheeler & Eric T. Kimchi & Aaron C. Ericsson & R. Scott Rector & Kevin F. Staveley-O’Carroll & Guangfu Li, 2023. "Western diet contributes to the pathogenesis of non-alcoholic steatohepatitis in male mice via remodeling gut microbiota and increasing production of 2-oleoylglycerol," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    14. Hannah Lees & Jonathan Swann & Simon M Poucher & Jeremy K Nicholson & Elaine Holmes & Ian D Wilson & Julian R Marchesi, 2014. "Age and Microenvironment Outweigh Genetic Influence on the Zucker Rat Microbiome," PLOS ONE, Public Library of Science, vol. 9(9), pages 1-11, September.
    15. Itay Daybog & Oren Kolodny, 2023. "A computational framework for resolving the microbiome diversity conundrum," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    16. Pamela N Luna & Jonathan M Mansbach & Chad A Shaw, 2020. "A joint modeling approach for longitudinal microbiome data improves ability to detect microbiome associations with disease," PLOS Computational Biology, Public Library of Science, vol. 16(12), pages 1-17, December.
    17. Edoardo Pasolli & Duy Tin Truong & Faizan Malik & Levi Waldron & Nicola Segata, 2016. "Machine Learning Meta-analysis of Large Metagenomic Datasets: Tools and Biological Insights," PLOS Computational Biology, Public Library of Science, vol. 12(7), pages 1-26, July.
    18. Sarah L Hagerty & Kent E Hutchison & Christopher A Lowry & Angela D Bryan, 2020. "An empirically derived method for measuring human gut microbiome alpha diversity: Demonstrated utility in predicting health-related outcomes among a human clinical sample," PLOS ONE, Public Library of Science, vol. 15(3), pages 1-21, March.
    19. Daniel Beck & James A Foster, 2014. "Machine Learning Techniques Accurately Classify Microbial Communities by Bacterial Vaginosis Characteristics," PLOS ONE, Public Library of Science, vol. 9(2), pages 1-8, February.
    20. Seung Jin Han & Kyoung Hwa Ha & Ja Young Jeon & Hae Jin Kim & Kwan Woo Lee & Dae Jung Kim, 2015. "Impact of Cadmium Exposure on the Association between Lipopolysaccharide and Metabolic Syndrome," IJERPH, MDPI, vol. 12(9), pages 1-14, September.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:18:y:2021:i:2:p:667-:d:480345. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.