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Arsenic Secondary Methylation Capacity Is Inversely Associated with Arsenic Exposure-Related Muscle Mass Reduction

Author

Listed:
  • Md. Khalequzzaman Sarker

    (Institute of Biological Sciences, University of Rajshahi, Rajshahi 6205, Bangladesh)

  • Selim Reza Tony

    (Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi 6205, Bangladesh)

  • Abu Eabrahim Siddique

    (Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi 6205, Bangladesh)

  • Md. Rezaul Karim

    (Department of Applied Nutrition and Food Technology, Islamic University, Kushtia 7003, Bangladesh)

  • Nazmul Haque

    (Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi 6205, Bangladesh)

  • Zohurul Islam

    (Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi 6205, Bangladesh)

  • Md. Shofikul Islam

    (Department of Applied Nutrition and Food Technology, Islamic University, Kushtia 7003, Bangladesh)

  • Moriom Khatun

    (Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi 6205, Bangladesh)

  • Jahidul Islam

    (Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi 6205, Bangladesh)

  • Shakhawoat Hossain

    (Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi 6205, Bangladesh)

  • Zahangir Alam Saud

    (Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi 6205, Bangladesh)

  • Hideki Miyataka

    (Laboratory of Molecular Nutrition and Toxicology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima 770-8514, Japan)

  • Daigo Sumi

    (Laboratory of Molecular Nutrition and Toxicology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima 770-8514, Japan)

  • Aaron Barchowsky

    (Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15261, USA)

  • Seiichiro Himeno

    (Laboratory of Molecular Nutrition and Toxicology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima 770-8514, Japan
    Division of Health Chemistry, School of Pharmacy, Showa University, Tokyo 142-8555, Japan)

  • Khaled Hossain

    (Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi 6205, Bangladesh)

Abstract

Skeletal muscle mass reduction has been implicated in insulin resistance (IR) that promotes cardiometabolic diseases. We have previously reported that arsenic exposure increases IR concomitantly with the reduction of skeletal muscle mass among individuals exposed to arsenic. The arsenic methylation capacity is linked to the susceptibility to some arsenic exposure-related diseases. However, it remains unknown whether the arsenic methylation capacity affects the arsenic-induced reduction of muscle mass and elevation of IR. Therefore, this study examined the associations between the arsenic methylation status and skeletal muscle mass measures with regard to IR by recruiting 437 participants from low- and high-arsenic exposure areas in Bangladesh. The subjects’ skeletal muscle mass was estimated by their lean body mass (LBM) and serum creatinine levels. Subjects’ drinking water arsenic concentrations were positively associated with total urinary arsenic concentrations and the percentages of MMA, as well as inversely associated with the percentages of DMA and the secondary methylation index (SMI). Subjects’ LBM and serum creatinine levels were positively associated with the percentage of DMA and SMI, as well as inversely associated with the percentage of MMA. HOMA-IR showed an inverse association with SMI, with a confounding effect of sex. Our results suggest that reduced secondary methylation capacity is involved in the arsenic-induced skeletal muscle loss that may be implicated in arsenic-induced IR and cardiometabolic diseases.

Suggested Citation

  • Md. Khalequzzaman Sarker & Selim Reza Tony & Abu Eabrahim Siddique & Md. Rezaul Karim & Nazmul Haque & Zohurul Islam & Md. Shofikul Islam & Moriom Khatun & Jahidul Islam & Shakhawoat Hossain & Zahangi, 2021. "Arsenic Secondary Methylation Capacity Is Inversely Associated with Arsenic Exposure-Related Muscle Mass Reduction," IJERPH, MDPI, vol. 18(18), pages 1-18, September.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:18:p:9730-:d:636255
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    References listed on IDEAS

    as
    1. Shirine Khazem & Leila Itani & Dima Kreidieh & Dana El Masri & Hana Tannir & Roberto Citarella & Marwan El Ghoch, 2018. "Reduced Lean Body Mass and Cardiometabolic Diseases in Adult Males with Overweight and Obesity: A Pilot Study," IJERPH, MDPI, vol. 15(12), pages 1-7, December.
    2. M M Hasibuzzaman & Shakhawoat Hossain & Md Shofikul Islam & Atiqur Rahman & Adiba Anjum & Faruk Hossain & Nayan Chandra Mohanto & Md Rezaul Karim & Md Mominul Hoque & Zahangir Alam Saud & Hideki Miyat, 2017. "Association between arsenic exposure and soluble thrombomodulin: A cross sectional study in Bangladesh," PLOS ONE, Public Library of Science, vol. 12(4), pages 1-16, April.
    3. Hui Shen & Qiang Niu & Mengchuan Xu & Dongsheng Rui & Shangzhi Xu & Gangling Feng & Yusong Ding & Shugang Li & Mingxia Jing, 2016. "Factors Affecting Arsenic Methylation in Arsenic-Exposed Humans: A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 13(2), pages 1-18, February.
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