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Association between arsenic exposure and soluble thrombomodulin: A cross sectional study in Bangladesh

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  • M M Hasibuzzaman
  • Shakhawoat Hossain
  • Md Shofikul Islam
  • Atiqur Rahman
  • Adiba Anjum
  • Faruk Hossain
  • Nayan Chandra Mohanto
  • Md Rezaul Karim
  • Md Mominul Hoque
  • Zahangir Alam Saud
  • Hideki Miyataka
  • Seiichiro Himeno
  • Khaled Hossain

Abstract

Chronic exposure to arsenic is associated with increased morbidity and mortality from cardiovascular disease (CVD); however, plausible biomarker for early prediction and the underlying mechanism of arsenic-related CVD have not yet been clearly understood. Endothelial dysfunction plays a central role in the development of CVD. We hypothesized that endothelial damage or dysfunction is an important aspect and may be an early event of arsenic-related CVD. Soluble thrombomodulin (sTM) in serum is thought to be a specific and stable marker for endothelial damage or dysfunction. This study was designed to evaluate the association between chronic exposure to arsenic and sTM among human subjects in arsenic-endemic and non-endemic rural areas in Bangladesh. A total of 321 study subjects (217 from arsenic-endemic areas and 104 from a non-endemic area) were recruited. Subjects’ arsenic exposure levels (i.e., drinking water, hair and nail arsenic concentrations) were measured by Inductively Coupled Plasma Mass Spectroscopy. The subjects’ serum sTM levels were quantified by immunoassay kit. The average sTM levels of the subjects in arsenic-endemic and non-endemic areas were 4.58 ± 2.20 and 2.84 ± 1.29 (ng mL-1) respectively, and the difference was significant (p

Suggested Citation

  • M M Hasibuzzaman & Shakhawoat Hossain & Md Shofikul Islam & Atiqur Rahman & Adiba Anjum & Faruk Hossain & Nayan Chandra Mohanto & Md Rezaul Karim & Md Mominul Hoque & Zahangir Alam Saud & Hideki Miyat, 2017. "Association between arsenic exposure and soluble thrombomodulin: A cross sectional study in Bangladesh," PLOS ONE, Public Library of Science, vol. 12(4), pages 1-16, April.
    • Handle: RePEc:plo:pone00:0175154
    DOI: 10.1371/journal.pone.0175154
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    Cited by:

    1. Md. Khalequzzaman Sarker & Selim Reza Tony & Abu Eabrahim Siddique & Md. Rezaul Karim & Nazmul Haque & Zohurul Islam & Md. Shofikul Islam & Moriom Khatun & Jahidul Islam & Shakhawoat Hossain & Zahangi, 2021. "Arsenic Secondary Methylation Capacity Is Inversely Associated with Arsenic Exposure-Related Muscle Mass Reduction," IJERPH, MDPI, vol. 18(18), pages 1-18, September.

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