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Arsenic Exposure and Risk of Urothelial Cancer: Systematic Review and Meta-Analysis

Author

Listed:
  • Pamela Di Giovanni

    (Department of Pharmacy, “G. d’Annunzio” University Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy)

  • Giuseppe Di Martino

    (Department of Medicine and Aging Sciences, “G. d’Annunzio” University Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy)

  • Piera Scampoli

    (School of Hygiene and Preventive Medicine, “G. d’Annunzio” University Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy)

  • Fabrizio Cedrone

    (School of Hygiene and Preventive Medicine, “G. d’Annunzio” University Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy)

  • Francesca Meo

    (School of Hygiene and Preventive Medicine, “G. d’Annunzio” University Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy)

  • Giuseppe Lucisano

    (Centre for Outcomes Research and Clinical Epidemiology (CORESEARCH), Via Tiziano Veciello, 65100 Pescara, Italy)

  • Ferdinando Romano

    (Department of Public Health and Infectious Diseases, “La Sapienza” University of Rome, P.zza Aldo Moro 5, 00100 Rome, Italy)

  • Tommaso Staniscia

    (Department of Medicine and Aging Sciences, “G. d’Annunzio” University Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy)

Abstract

Background : Arsenic is a toxic metalloid element widely distributed throughout the environment. Arsenic contaminated water has become an ongoing public health issue affecting hundred million people worldwide. The aim of this paper was to summarize the evidence in the association between arsenic metabolites and urinary tract cancer risk. Methods : A systematic review was conducted searching for observational studies that evaluated the association of arsenic metabolites and urinary tract cancer. Risk estimates from individual studies were pooled by using random effects models. Results : All the metabolites considered in this study resulted to be significantly associated to urothelial cancer, respectively: IA% 3.51 (1.21–5.82) ( p = 0.003), MMA with WMD = 2.77 (1.67–3.87) ( p < 0.001) and DMA with WMD = −4.56 (−7.91–1.22) ( p = 0.008). Conclusions : Arsenic metabolites are significantly associated to urothelial cancer. Future studies will help to verify the independent association(s) between arsenic metabolites and urothelial cancer.

Suggested Citation

  • Pamela Di Giovanni & Giuseppe Di Martino & Piera Scampoli & Fabrizio Cedrone & Francesca Meo & Giuseppe Lucisano & Ferdinando Romano & Tommaso Staniscia, 2020. "Arsenic Exposure and Risk of Urothelial Cancer: Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 17(9), pages 1-11, April.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:9:p:3105-:d:352004
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    References listed on IDEAS

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    1. Hui Shen & Qiang Niu & Mengchuan Xu & Dongsheng Rui & Shangzhi Xu & Gangling Feng & Yusong Ding & Shugang Li & Mingxia Jing, 2016. "Factors Affecting Arsenic Methylation in Arsenic-Exposed Humans: A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 13(2), pages 1-18, February.
    2. Olaf M Dekkers & Jan P Vandenbroucke & Myriam Cevallos & Andrew G Renehan & Douglas G Altman & Matthias Egger, 2019. "COSMOS-E: Guidance on conducting systematic reviews and meta-analyses of observational studies of etiology," PLOS Medicine, Public Library of Science, vol. 16(2), pages 1-24, February.
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    Cited by:

    1. Elisa Bustaffa & Francesca Gorini & Fabrizio Bianchi & Fabrizio Minichilli, 2020. "Factors Affecting Arsenic Methylation in Contaminated Italian Areas," IJERPH, MDPI, vol. 17(14), pages 1-21, July.

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