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Anxiety Levels Predict Bone Mineral Density in Postmenopausal Women Undergoing Oral Bisphosphonates: A Two-Year Follow-Up

Author

Listed:
  • Gabriella Martino

    (Department of Clinical and Experimental Medicine, University Hospital of Messina, 98122 Messina, Italy)

  • Federica Bellone

    (Department of Clinical and Experimental Medicine, University Hospital of Messina, 98122 Messina, Italy)

  • Carmelo M. Vicario

    (Department of Cognitive Sciences, Psychology, Education and Cultural Studies, University of Messina, 98121 Messina, Italy)

  • Agostino Gaudio

    (Department of Clinical and Experimental Medicine, University Hospital of Catania, 95123 Catania, Italy)

  • Andrea Caputo

    (Department of Dynamic and Clinical Psychology and Health Studies, Sapienza University of Rome, 00185 Rome, Italy)

  • Francesco Corica

    (Department of Clinical and Experimental Medicine, University Hospital of Messina, 98122 Messina, Italy)

  • Giovanni Squadrito

    (Department of Clinical and Experimental Medicine, University Hospital of Messina, 98122 Messina, Italy)

  • Peter Schwarz

    (Department of Endocrinology, Research Centre for Ageing and Osteoporosis, Rigshospitalet-Glostrup Hospital, 2100 Copenhagen, Denmark)

  • Nunziata Morabito

    (Department of Clinical and Experimental Medicine, University Hospital of Messina, 98122 Messina, Italy)

  • Antonino Catalano

    (Department of Clinical and Experimental Medicine, University Hospital of Messina, 98122 Messina, Italy)

Abstract

Clinical psychological factors may predict medical diseases. Anxiety level has been associated with osteoporosis, but its role on bone mineral density (BMD) change is still unknown. This study aimed to investigate the association between anxiety levels and both adherence and treatment response to oral bisphosphonates (BPs) in postmenopausal osteoporosis. BMD and anxiety levels were evaluated trough dual-energy X-ray absorptiometry and the Hamilton Anxiety Rating Scale (HAM-A), respectively. Participants received weekly medication with alendronate or risedronate and were grouped according to the HAM-A scores into tertiles (HAM-A 3 > HAM-A 2 > HAM-A 1). After 24 months, BMD changes were different among the HAM-A tertiles. The median lumbar BMD change was significantly greater in both the HAM-A 2 and HAM-A 3 in comparison with the HAM-A 1. The same trend was observed for femoral BMD change. Adherence to BPs was >75% in 68% of patients in the HAM-A 1, 79% of patients in the HAM-A 2, and 89% of patients in the HAM-A 3 ( p = 0.0014). After correcting for age, body mass index, depressive symptoms, and the 10-yr. probability of osteoporotic fractures, anxiety levels independently predicted lumbar BMD change (β = 0.3417, SE 0.145, p = 0.02). In conclusion, women with higher anxiety levels reported greater BMD improvement, highlighting that anxiety was associated with adherence and response to osteoporosis medical treatment, although further research on this topic is needed.

Suggested Citation

  • Gabriella Martino & Federica Bellone & Carmelo M. Vicario & Agostino Gaudio & Andrea Caputo & Francesco Corica & Giovanni Squadrito & Peter Schwarz & Nunziata Morabito & Antonino Catalano, 2021. "Anxiety Levels Predict Bone Mineral Density in Postmenopausal Women Undergoing Oral Bisphosphonates: A Two-Year Follow-Up," IJERPH, MDPI, vol. 18(15), pages 1-12, July.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:15:p:8144-:d:606414
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    References listed on IDEAS

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    1. Elżbieta Grochans & Małgorzata Szkup & Artur Kotwas & Jacek Kopeć & Beata Karakiewicz & Anna Jurczak, 2018. "Analysis of Sociodemographic, Psychological, and Genetic Factors Contributing to Depressive symptoms in Pre-, Peri- and Postmenopausal Women," IJERPH, MDPI, vol. 15(4), pages 1-15, April.
    2. Eva Esteban & Michaela Coenen & Elizabeth Ito & Sonja Gruber & Chiara Scaratti & Matilde Leonardi & Olga Roka & Evdokia Vasilou & Amalia Muñoz-Murillo & Carolina C. Ávila & Dare S. Kovačič & Ivana Iva, 2018. "Views and Experiences of Persons with Chronic Diseases about Strategies that Aim to Integrate and Re-Integrate Them into Work: A Systematic Review of Qualitative Studies," IJERPH, MDPI, vol. 15(5), pages 1-28, May.
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