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Quercetin and Its Mixture Increase the Stress Resistance of Caenorhabditis elegans to UV-B

Author

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  • Shi-ming Li

    (College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China)

  • Dan Liu

    (College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China)

  • Yi-lin Liu

    (College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China)

  • Bin Liu

    (College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China
    National Engineering Research Center of JUNCAO Technology, Fujian Agriculture and Forestry University, Fuzhou 350002, China)

  • Xing-huang Chen

    (College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China)

Abstract

Ultraviolet B (UV-B, 280–320 nm) radiation causes complex molecular reactions in cells, including DNA damage, oxidative stress, and apoptosis. This study designed a mixture consisting of quercetin, luteolin and lycopene and used Caenorhabditis elegans as a model to study the resistance of these natural chemicals to UV-B. Specifically, we have confirmed that quercetin and its mixture can increase the resistance of Caenorhabditis elegans to UV-B through lifespan test, reactive oxygen species level assay, germ cell apoptosis test, embryonic lethal test and RT-qPCR experiments. The results show that quercetin and its mixture prolonged the lifespan of UV-B-irradiated Caenorhabditis elegans and reduced abnormal levels of reactive oxygen species, embryo death, and apoptosis induced by UV-B. The protective effect of quercetin and its mixture may be attributed to its down-regulation of HUS-1 , CEP-1 , EGL-1 and CED-13. Therefore, the results of this research could help the development of UV-B radiation protection agents.

Suggested Citation

  • Shi-ming Li & Dan Liu & Yi-lin Liu & Bin Liu & Xing-huang Chen, 2020. "Quercetin and Its Mixture Increase the Stress Resistance of Caenorhabditis elegans to UV-B," IJERPH, MDPI, vol. 17(5), pages 1-13, February.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:5:p:1572-:d:326489
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    References listed on IDEAS

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    1. Yu Peng & Man Zhang & Lingjun Zheng & Qian Liang & Hanzeng Li & Jeng-Ting Chen & Hongyan Guo & Sawako Yoshina & Yu-Zen Chen & Xiang Zhao & Xiaoqi Wu & Bin Liu & Shohei Mitani & Jau-Song Yu & Ding Xue, 2017. "Cysteine protease cathepsin B mediates radiation-induced bystander effects," Nature, Nature, vol. 547(7664), pages 458-462, July.
    2. Marta Artal-Sanz & Nektarios Tavernarakis, 2009. "Prohibitin couples diapause signalling to mitochondrial metabolism during ageing in C. elegans," Nature, Nature, vol. 461(7265), pages 793-797, October.
    3. Michael O. Hengartner, 2000. "The biochemistry of apoptosis," Nature, Nature, vol. 407(6805), pages 770-776, October.
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