IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v17y2020i24p9522-d464858.html
   My bibliography  Save this article

The Utility of Novel Renal Biomarkers in Assessment of Chronic Kidney Disease of Unknown Etiology (CKDu): A Review

Author

Listed:
  • T.D.K.S.C. Gunasekara

    (Department of Zoology, Faculty of Science, University of Ruhuna, Matara 81000, Sri Lanka)

  • P. Mangala C.S. De Silva

    (Department of Zoology, Faculty of Science, University of Ruhuna, Matara 81000, Sri Lanka
    Renal Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA)

  • Chula Herath

    (Department of Nephrology, Sri Jayawardenapura General Hospital, Sri Jayawardenepura Kotte 10100, Sri Lanka)

  • Sisira Siribaddana

    (Department of Medicine, Faculty of Medicine and Allied Sciences, Rajarata University of Sri Lanka, Mihintale 50300, Sri Lanka)

  • Nipuna Siribaddana

    (Department of Parasitology, Faculty of Medicine and Allied Sciences, Rajarata University of Sri Lanka, Mihintale 50300, Sri Lanka)

  • Channa Jayasumana

    (Department of Pharmacology, Faculty of Medicine and Allied Sciences, Rajarata University of Sri Lanka, Mihintale 50300, Sri Lanka)

  • Sudheera Jayasinghe

    (Department of Pharmacology, Faculty of Medicine, University of Ruhuna, Matara 81000, Sri Lanka)

  • Maria Cardenas-Gonzalez

    (Renal Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Mexican Council of Science and Technology, Consejo Nacional de Ciencia y Tecnología, Mexico City 03940, Mexico)

  • Nishad Jayasundara

    (The Nicholas School of the Environment, Duke University, Durham, NC 27708, USA
    The School of Marine Sciences, University of Maine, Orono, ME 04469, USA)

Abstract

Chronic Kidney Disease (CKD) is a globally prevalent non-communicable disease with significant mortality and morbidity. It is typically associated with diabetes and hypertension; however, over the last two decades, an emergence of CKD of unknown etiology (CKDu) has claimed thousands of lives in several tropical agricultural communities. CKDu is associated with gradual loss of renal function without initial symptoms until reaching complete kidney failure and eventually death. The most impacted are young adult males of lower socio-economic strata. Since the disease progression can be successfully attenuated through early detection, the development of superior screening and management measures is of utmost importance. In contrast to the conventional biomarkers, novel biomarkers with improved sensitivity and specificity are being discussed as promising tools for early diagnosis of the disease. This review summarizes emerging novel biomarkers used in assessing CKD and discusses the current utility and diagnostic potential of such biomarkers for CKDu screening in clinical settings of different communities impacted by CKDu. Our goal is to provide a framework for practitioners in CKDu impacted regions to consider the use of these novel biomarkers through this synthesis. The increased use of these biomarkers will not only help to validate their diagnostic power further and establish potential prognostic value but may also provide critical insights into sites and mechanisms of renal damage.

Suggested Citation

  • T.D.K.S.C. Gunasekara & P. Mangala C.S. De Silva & Chula Herath & Sisira Siribaddana & Nipuna Siribaddana & Channa Jayasumana & Sudheera Jayasinghe & Maria Cardenas-Gonzalez & Nishad Jayasundara, 2020. "The Utility of Novel Renal Biomarkers in Assessment of Chronic Kidney Disease of Unknown Etiology (CKDu): A Review," IJERPH, MDPI, vol. 17(24), pages 1-21, December.
  • Handle: RePEc:gam:jijerp:v:17:y:2020:i:24:p:9522-:d:464858
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/17/24/9522/pdf
    Download Restriction: no

    File URL: https://www.mdpi.com/1660-4601/17/24/9522/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Laila Fitria & Nurhayati Adnan Prihartono & Doni Hikmat Ramdhan & Tri Yunis Miko Wahyono & Pornpimol Kongtip & Susan Woskie, 2020. "Environmental and Occupational Risk Factors Associated with Chronic Kidney Disease of Unknown Etiology in West Javanese Rice Farmers, Indonesia," IJERPH, MDPI, vol. 17(12), pages 1-14, June.
    2. de Silva, M.W. Amarasiri & Albert, Steven M. & Jayasekara, J.M.K.B., 2017. "Structural violence and chronic kidney disease of unknown etiology in Sri Lanka," Social Science & Medicine, Elsevier, vol. 178(C), pages 184-195.
    3. Kafle, Kashi & Balasubramanya, Soumya & Horbulyk, Ted, 2019. "Prevalence of chronic kidney disease in Sri Lanka: a profile of affected districts reliant on groundwater," Papers published in Journals (Open Access), International Water Management Institute, pages 694:133767..
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. E. M. D. V. Ekanayake & T. D. K. S. C. Gunasekara & P. Mangala C. S. De Silva & Sudheera Jayasinghe & E. P. S. Chandana & Nishad Jayasundara, 2022. "Applicability of Novel Urinary Biomarkers for the Assessment of Renal Injury in Selected Occupational Groups in Sri Lanka: A Comparative Study with Conventional Markers," IJERPH, MDPI, vol. 19(9), pages 1-15, April.
    2. K.S.M. Abdul & P. Mangala C.S. De Silva & E.M.D.V. Ekanayake & W.A.K.G. Thakshila & S.D. Gunarathna & T.D.K.S.C. Gunasekara & S.S. Jayasinghe & H.B. Asanthi & E.P.S. Chandana & G.G.T. Chaminda & S.H. , 2021. "Occupational Paraquat and Glyphosate Exposure May Decline Renal Functions among Rural Farming Communities in Sri Lanka," IJERPH, MDPI, vol. 18(6), pages 1-18, March.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Panter-Brick, Catherine & Eggerman, Mark, 2018. "The field of medical anthropology in Social Science & Medicine," Social Science & Medicine, Elsevier, vol. 196(C), pages 233-239.
    2. E. M. D. V. Ekanayake & T. D. K. S. C. Gunasekara & P. Mangala C. S. De Silva & Sudheera Jayasinghe & E. P. S. Chandana & Nishad Jayasundara, 2022. "Applicability of Novel Urinary Biomarkers for the Assessment of Renal Injury in Selected Occupational Groups in Sri Lanka: A Comparative Study with Conventional Markers," IJERPH, MDPI, vol. 19(9), pages 1-15, April.
    3. Imbulana, Sachithra Madhushani, 2022. "Groundwater Quality in the Endemic Areas of Chronic Kidney Disease of Unknown Etiology in Sri Lanka and Its Treatment by Community-Based Reverse Osmosis Water Treatment Plants," ADBI Working Papers 1309, Asian Development Bank Institute.
    4. Li, Qiyuan & Zhang, Huili & Tan, Cheng & Lian, Boyue & García-Pacheco, Raquel & Taylor, Robert A. & Fletcher, John & Le-Clech, Pierre & Ranasinghe, Buddhi & Senevirathna, Tharanga & Leslie, Gregory, 2022. "Numerical and experimental investigation of a DC-powered RO system for Sri-Lankan villages," Renewable Energy, Elsevier, vol. 182(C), pages 772-786.
    5. Kristina Jakobsson & Jason Glaser & Catharina Wesseling, 2020. "Prevalence Studies on CKDu Need Stringent Reporting on Outcomes to Enhance Comparability," IJERPH, MDPI, vol. 17(18), pages 1-3, September.
    6. Laila Fitria & Nurhayati Adnan Prihartono & Doni Hikmat Ramdhan & Susan Woskie, 2020. "Reply to “Comment on Fitria et al. ‘Environmental and Occupational Risk Factors Associated with Chronic Kidney Disease of Unknown Etiology in West Javanese Rice Farmers, Indonesia’ Int. J. Environ. Re," IJERPH, MDPI, vol. 17(19), pages 1-4, October.
    7. Nurhayati Adnan Prihartono & Laila Fitria & Doni Hikmat Ramdhan & Fitriyani Fitriyani & Sifa Fauzia & Susan Woskie, 2022. "Determinants of Hypertension amongst Rice Farmers in West Java, Indonesia," IJERPH, MDPI, vol. 19(3), pages 1-13, January.
    8. I. D. U. H. Piyathilake & J. L. P. C. Randika & R. M. K. T. Rathnayaka & E. P. N. Udayakumara & L. V. Ranaweera & S. K. Gunatilake & C. B. Dissanayake, 2022. "Socio-economic determinants of Chronic Kidney Diseases of uncertain etiology (CKDu) in the Uva Province, Sri Lanka: a cross-sectional study," Journal of Environmental Studies and Sciences, Springer;Association of Environmental Studies and Sciences, vol. 12(4), pages 782-793, December.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:17:y:2020:i:24:p:9522-:d:464858. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.