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Exercise-Induced Circulating Irisin Level Is Correlated with Improved Cardiac Function in Rats

Author

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  • Dae Yun Seo

    (National Research Laboratory for Mitochondrial Signaling, Department of Physiology, BK21 Plus Project Team, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan 47392, Korea
    Smart Marine Therapeutics Center, Inje Univeristy, Busan 47392, Korea)

  • Jun Hyun Bae

    (Institute of Sport Science, Seoul National University, Seoul 08826, Korea)

  • Tae Nyun Kim

    (National Research Laboratory for Mitochondrial Signaling, Department of Physiology, BK21 Plus Project Team, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan 47392, Korea
    Smart Marine Therapeutics Center, Inje Univeristy, Busan 47392, Korea)

  • Hyo-Bum Kwak

    (Department of Kinesiology, Inha University, Incheon 22212, Korea)

  • Pham Trong Kha

    (National Research Laboratory for Mitochondrial Signaling, Department of Physiology, BK21 Plus Project Team, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan 47392, Korea
    Smart Marine Therapeutics Center, Inje Univeristy, Busan 47392, Korea)

  • Jin Han

    (National Research Laboratory for Mitochondrial Signaling, Department of Physiology, BK21 Plus Project Team, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan 47392, Korea
    Smart Marine Therapeutics Center, Inje Univeristy, Busan 47392, Korea)

Abstract

Irisin, a recently identified myokine, plays an important physiological role in modulating energy homeostasis. However, the role of irisin in cardiac function during exercise has not been evaluated. In this study, we investigated the effect of exercise on irisin, pro-inflammatory cytokines, and cardiac function during 12 weeks of exercise in rats. Eight-week-old Sprague-Dawley male rats were randomly divided into two groups (n = 9 per group): sedentary control (CON) and exercise (EXE) groups. The EXE group was trained on a motorized treadmill at 20 m/min, for 60 min/day, five times/week for 12 weeks. The EXE group showed a decrease in abdominal visceral fat ( p < 0.05), epididymal fat ( p < 0.01), and total cholesterol (TC) ( p < 0.05) and an increase in irisin levels ( p < 0.01). Irisin negatively correlated with abdominal visceral ( p < 0.05) and epididymal fat ( p < 0.05) and positively correlated with the ejection fraction ( p < 0.05), fractional shortening ( p < 0.05), and cardiac output ( p < 0.05). In conclusion, exercise decreases the abdominal visceral and epididymal fat and TC levels, possibly caused by elevated irisin levels, thus improving the cardiac function. This suggests that exercise-induced circulating irisin levels correlate with improved cardiac function in rats.

Suggested Citation

  • Dae Yun Seo & Jun Hyun Bae & Tae Nyun Kim & Hyo-Bum Kwak & Pham Trong Kha & Jin Han, 2020. "Exercise-Induced Circulating Irisin Level Is Correlated with Improved Cardiac Function in Rats," IJERPH, MDPI, vol. 17(11), pages 1-11, May.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:11:p:3863-:d:364728
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    References listed on IDEAS

    as
    1. Ji Yu Im & Hyun Seok Bang & Dae Yun Seo, 2019. "The Effects of 12 Weeks of a Combined Exercise Program on Physical Function and Hormonal Status in Elderly Korean Women," IJERPH, MDPI, vol. 16(21), pages 1-11, October.
    2. Harald Staiger & Anja Böhm & Mika Scheler & Lucia Berti & Jürgen Machann & Fritz Schick & Fausto Machicao & Andreas Fritsche & Norbert Stefan & Cora Weigert & Anna Krook & Hans-Ulrich Häring & Martin , 2013. "Common Genetic Variation in the Human FNDC5 Locus, Encoding the Novel Muscle-Derived ‘Browning’ Factor Irisin, Determines Insulin Sensitivity," PLOS ONE, Public Library of Science, vol. 8(4), pages 1-11, April.
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