IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v17y2020i11p3863-d364728.html
   My bibliography  Save this article

Exercise-Induced Circulating Irisin Level Is Correlated with Improved Cardiac Function in Rats

Author

Listed:
  • Dae Yun Seo

    (National Research Laboratory for Mitochondrial Signaling, Department of Physiology, BK21 Plus Project Team, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan 47392, Korea
    Smart Marine Therapeutics Center, Inje Univeristy, Busan 47392, Korea)

  • Jun Hyun Bae

    (Institute of Sport Science, Seoul National University, Seoul 08826, Korea)

  • Tae Nyun Kim

    (National Research Laboratory for Mitochondrial Signaling, Department of Physiology, BK21 Plus Project Team, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan 47392, Korea
    Smart Marine Therapeutics Center, Inje Univeristy, Busan 47392, Korea)

  • Hyo-Bum Kwak

    (Department of Kinesiology, Inha University, Incheon 22212, Korea)

  • Pham Trong Kha

    (National Research Laboratory for Mitochondrial Signaling, Department of Physiology, BK21 Plus Project Team, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan 47392, Korea
    Smart Marine Therapeutics Center, Inje Univeristy, Busan 47392, Korea)

  • Jin Han

    (National Research Laboratory for Mitochondrial Signaling, Department of Physiology, BK21 Plus Project Team, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan 47392, Korea
    Smart Marine Therapeutics Center, Inje Univeristy, Busan 47392, Korea)

Abstract

Irisin, a recently identified myokine, plays an important physiological role in modulating energy homeostasis. However, the role of irisin in cardiac function during exercise has not been evaluated. In this study, we investigated the effect of exercise on irisin, pro-inflammatory cytokines, and cardiac function during 12 weeks of exercise in rats. Eight-week-old Sprague-Dawley male rats were randomly divided into two groups (n = 9 per group): sedentary control (CON) and exercise (EXE) groups. The EXE group was trained on a motorized treadmill at 20 m/min, for 60 min/day, five times/week for 12 weeks. The EXE group showed a decrease in abdominal visceral fat ( p < 0.05), epididymal fat ( p < 0.01), and total cholesterol (TC) ( p < 0.05) and an increase in irisin levels ( p < 0.01). Irisin negatively correlated with abdominal visceral ( p < 0.05) and epididymal fat ( p < 0.05) and positively correlated with the ejection fraction ( p < 0.05), fractional shortening ( p < 0.05), and cardiac output ( p < 0.05). In conclusion, exercise decreases the abdominal visceral and epididymal fat and TC levels, possibly caused by elevated irisin levels, thus improving the cardiac function. This suggests that exercise-induced circulating irisin levels correlate with improved cardiac function in rats.

Suggested Citation

  • Dae Yun Seo & Jun Hyun Bae & Tae Nyun Kim & Hyo-Bum Kwak & Pham Trong Kha & Jin Han, 2020. "Exercise-Induced Circulating Irisin Level Is Correlated with Improved Cardiac Function in Rats," IJERPH, MDPI, vol. 17(11), pages 1-11, May.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:11:p:3863-:d:364728
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/17/11/3863/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/17/11/3863/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Harald Staiger & Anja Böhm & Mika Scheler & Lucia Berti & Jürgen Machann & Fritz Schick & Fausto Machicao & Andreas Fritsche & Norbert Stefan & Cora Weigert & Anna Krook & Hans-Ulrich Häring & Martin , 2013. "Common Genetic Variation in the Human FNDC5 Locus, Encoding the Novel Muscle-Derived ‘Browning’ Factor Irisin, Determines Insulin Sensitivity," PLOS ONE, Public Library of Science, vol. 8(4), pages 1-11, April.
    2. Ji Yu Im & Hyun Seok Bang & Dae Yun Seo, 2019. "The Effects of 12 Weeks of a Combined Exercise Program on Physical Function and Hormonal Status in Elderly Korean Women," IJERPH, MDPI, vol. 16(21), pages 1-11, October.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Patricia Alexandra García-Garro & Fidel Hita-Contreras & Antonio Martínez-Amat & Alexander Achalandabaso-Ochoa & José Daniel Jiménez-García & David Cruz-Díaz & Agustín Aibar-Almazán, 2020. "Effectiveness of A Pilates Training Program on Cognitive and Functional Abilities in Postmenopausal Women," IJERPH, MDPI, vol. 17(10), pages 1-12, May.
    2. Victor Machado Reis, 2020. "Effects of Exercise on Biomarkers in Health and Disease: Some New Insights with Special Focus on Extreme Exercise and Healthy Ageing," IJERPH, MDPI, vol. 17(6), pages 1-5, March.
    3. Jong-Hwan Park & Yung Liao & Du-Ri Kim & Seunghwan Song & Jun Ho Lim & Hyuntae Park & Yeanhwa Lee & Kyung Won Park, 2020. "Feasibility and Tolerability of a Culture-Based Virtual Reality (VR) Training Program in Patients with Mild Cognitive Impairment: A Randomized Controlled Pilot Study," IJERPH, MDPI, vol. 17(9), pages 1-9, April.
    4. Won-Sang Jung & Sung-Woo Kim & Hun-Young Park, 2020. "Interval Hypoxic Training Enhances Athletic Performance and Does Not Adversely Affect Immune Function in Middle- and Long-Distance Runners," IJERPH, MDPI, vol. 17(6), pages 1-15, March.
    5. Jing-Yi Ai & Garry Kuan & Linda Ya-Ting Juang & Ching-Hsiu Lee & Yee-Cheng Kueh & I-Hua Chu & Xiao-Ling Geng & Yu-Kai Chang, 2022. "Effects of Multi-Component Exercise on Sleep Quality in Middle-Aged Adults," IJERPH, MDPI, vol. 19(23), pages 1-11, November.
    6. Yuting Tang & Xian Guo & Yi Wang & Zeyao Liu & Guoxia Cao & Yanbing Zhou & Mengmeng Chen & Jingying Liu & Jinhao Mu & Mengjie Yuan, 2022. "Rumba Dance Combined with Breathing Training as an Exercise Intervention in the Management of Stress Urinary Incontinence in Postmenopausal Women: A Randomized Controlled Trial," IJERPH, MDPI, vol. 20(1), pages 1-13, December.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:17:y:2020:i:11:p:3863-:d:364728. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.