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A Panel Study on Lung Function and Bronchial Inflammation among Children Exposed to Ambient SO 2 from an Oil Refinery

Author

Listed:
  • Fabio Barbone

    (Institute for Maternal and Child Health, IRCCS Burlo Garofolo, via dell’Istria 65/1, 34137 Trieste, Italy)

  • Dolores Catelan

    (Department of Statistics, Computer Science, Applications “G. Parenti” University of Florence, Viale Morgagni, 59, 50134 Firenze, Italy)

  • Riccardo Pistelli

    (School of Respiratory Medicine, Sacro Cuore University, Largo Francesco Vito 1, 00168 Rome, Italy)

  • Gabriele Accetta

    (Department of Statistics, Computer Science, Applications “G. Parenti” University of Florence, Viale Morgagni, 59, 50134 Firenze, Italy)

  • Daniele Grechi

    (Epidemiologia e Prevenzione, no profit social enterprise, via Ricciarelli 29, 20148 Milan, Italy)

  • Franca Rusconi

    (Unit of Epidemiology, “Anna Meyer” Children’s University Hospital, Viale Pieraccini 24, 50139 Florence, Italy)

  • Annibale Biggeri

    (Department of Statistics, Computer Science, Applications “G. Parenti” University of Florence, Viale Morgagni, 59, 50134 Firenze, Italy)

Abstract

To determine the acute effects on respiratory function of children exposed to sulphur dioxide (SO 2 ), we conducted two population-based longitudinal investigations near a major oil refinery. We enrolled 233 children, age 8–14, in Sarroch (Italy). The first study entailed five monthly spirometric visits (Panel 5). In a subgroup, children positive for history of respiratory symptoms were tested weekly (20 times) with spirometry and fractional exhaled nitric oxide (FeNO) measurement (Panel 20). Baseline questionnaires and daily diaries were recorded. SO 2 , NO 2 , PM 10 and O 3 were measured by monitoring stations. Multiple regression models were fitted. Using a multipollutant model, we found that a 10 µg/m 3 SO 2 increase at lag0–2 days determined a percent variation (PV) of −3.37 (90% confidence interval, CI: −5.39; −1.30) for forced expiratory volume after one second (FEV1) in Panel 5 and a PV = −3.51 (90% CI: −4.77; −2.23) in Panel 20. We found a strong dose-response relation: 1-h SO 2 peaks >200 µg/m 3 at lag2 days = FEV1 PV −2.49. For FeNO, we found a PV = 38.12 (90% CI: 12.88; 69.01) for each 10 µg/m 3 SO 2 increase at 8-h time lag and a strong dose-response relation. Exposure to SO 2 is strongly associated with reduction of lung function and an increase in airway inflammation. This new evidence of harmful effects of SO 2 peaks should induce regulatory intervention.

Suggested Citation

  • Fabio Barbone & Dolores Catelan & Riccardo Pistelli & Gabriele Accetta & Daniele Grechi & Franca Rusconi & Annibale Biggeri, 2019. "A Panel Study on Lung Function and Bronchial Inflammation among Children Exposed to Ambient SO 2 from an Oil Refinery," IJERPH, MDPI, vol. 16(6), pages 1-18, March.
  • Handle: RePEc:gam:jijerp:v:16:y:2019:i:6:p:1057-:d:216619
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    References listed on IDEAS

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    1. Luigi Vimercati & Maria Franca Gatti & Antonio Baldassarre & Eustachio Nettis & Nicola Favia & Marco Palma & Gabriella Lucia Maria Martina & Elisabetta Di Leo & Marina Musti, 2015. "Occupational Exposure to Urban Air Pollution and Allergic Diseases," IJERPH, MDPI, vol. 12(10), pages 1-11, October.
    2. Pablo Orellano & Nancy Quaranta & Julieta Reynoso & Brenda Balbi & Julia Vasquez, 2017. "Effect of outdoor air pollution on asthma exacerbations in children and adults: Systematic review and multilevel meta-analysis," PLOS ONE, Public Library of Science, vol. 12(3), pages 1-15, March.
    3. Luigi Vimercati & Antonio Baldassarre & Maria Franca Gatti & Luigi De Maria & Antonio Caputi & Angelica A. Dirodi & Francesco Cuccaro & Raffaello Maria Bellino, 2016. "Respiratory Health in Waste Collection and Disposal Workers," IJERPH, MDPI, vol. 13(7), pages 1-8, June.
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    Cited by:

    1. Joaquín Hernández-Fernández & Heidi Cano & Susana Rodríguez-Couto, 2022. "Quantification and Removal of Volatile Sulfur Compounds (VSCs) in Atmospheric Emissions in Large (Petro) Chemical Complexes in Different Countries of America and Europe," Sustainability, MDPI, vol. 14(18), pages 1-18, September.
    2. Eric Amster & Clara Lew Levy, 2019. "Impact of Coal-fired Power Plant Emissions on Children’s Health: A Systematic Review of the Epidemiological Literature," IJERPH, MDPI, vol. 16(11), pages 1-11, June.

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